| Mar 04, 2026 | Timothy Williams | SVP & GENERAL COUNSEL | -42.43K | $8.27 | -$350.76K | SELL | -10.11% | 377.45K | Mar 02 | View |
| Mar 04, 2026 | Kevin Patrick Moran | SVP, CFO & TREASURER | -42.44K | $8.27 | -$350.82K | SELL | -9.34% | 412.01K | Mar 02 | View |
| Mar 04, 2026 | Joakim Wijkstrom | SVP, CHIEF MARKETING OFFICER | -30.80K | $8.27 | -$254.59K | SELL | -8.46% | 333.47K | Mar 02 | View |
| Mar 04, 2026 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | -156.24K | $8.17 | -$1.28M | SELL | -5.46% | 2.70M | Mar 02 | View |
| Mar 04, 2026 | Gunther Birznieks | SVP, BUSINESS DEVELOPMENT | -42.43K | $8.27 | -$350.73K | SELL | -7.91% | 494.20K | Mar 02 | View |
| Feb 24, 2026 | Tage Honore | — | -30.00K | $8.03 | -$240.90K | SELL | -24.30% | 93.47K | Feb 23 | View |
| Aug 08, 2025 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | 10.00K | $4.15 | $41.50K | BUY | 0.43% | 2.34M | Aug 07 | View |
| Jun 16, 2025 | Stephen Ray Mitchell | — | -7.00K | $4.59 | -$32.13K | SELL | -6.73% | 97.08K | Jun 13 | View |
| May 21, 2025 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | 10.00K | $4.40 | $44.00K | BUY | 0.43% | 2.33M | May 21 | View |
| May 19, 2025 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | 20.00K | $4.22 | $84.47K | BUY | 0.87% | 2.32M | May 16 | View |
| Mar 06, 2025 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | 10.00K | $5.01 | $50.15K | BUY | 0.44% | 2.30M | Mar 06 | View |
| Mar 05, 2025 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | 10.00K | $5.02 | $50.20K | BUY | 0.44% | 2.29M | Mar 05 | View |
| Mar 04, 2025 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | -86.00K | $4.73 | -$409.91K | TAX | -3.64% | 2.28M | Mar 01 - Mar 03 | View |
| Feb 28, 2025 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | 10.00K | $4.76 | $47.60K | BUY | 0.43% | 2.36M | Feb 28 | View |
| Feb 27, 2025 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | 10.00K | $4.76 | $47.60K | BUY | 0.43% | 2.35M | Feb 27 | View |
| Feb 26, 2025 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | 10.00K | $4.76 | $47.65K | BUY | 0.43% | 2.34M | Feb 26 | View |
| Feb 25, 2025 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | 10.00K | $4.46 | $44.64K | BUY | 0.43% | 2.33M | Feb 25 | View |
| Feb 24, 2025 | Kevin Patrick Moran | SVP, CFO & TREASURER | 2.00K | $4.39 | $8.78K | BUY | 0.56% | 356.40K | Feb 21 | View |
| Nov 18, 2024 | Stephen Ray Mitchell | — | -5.00K | $5.17 | -$25.86K | SELL | -10.03% | 44.86K | Nov 14 | View |
| Jul 29, 2024 | Kevin Patrick Moran | SVP, CFO & TREASURER | -2.25K | $5.92 | -$13.33K | SELL | -0.97% | 229.40K | Jul 29 | View |
| Mar 06, 2024 | Timothy Williams | SVP & GENERAL COUNSEL | -17.09K | $4.29 | -$73.31K | SELL | -7.99% | 196.82K | Mar 04 - Mar 05 | View |
| Mar 06, 2024 | Joakim Wijkstrom | SVP, CHIEF MARKETING OFFICER | -16.73K | $4.30 | -$71.92K | SELL | -11.42% | 129.79K | Mar 04 - Mar 05 | View |
| Mar 06, 2024 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | -55.17K | $4.19 | -$231.34K | SELL | -2.86% | 1.87M | Mar 04 - Mar 05 | View |
| Mar 06, 2024 | Kevin Patrick Moran | SVP, CFO & TREASURER | -14.70K | $4.31 | -$63.39K | SELL | -5.97% | 231.65K | Mar 04 - Mar 05 | View |
| Mar 06, 2024 | Gunther Birznieks | SVP, BUSINESS DEVELOPMENT | -17.41K | $4.21 | -$73.38K | SELL | -5.26% | 313.57K | Mar 04 - Mar 05 | View |
| Aug 23, 2023 | Joakim Wijkstrom | SVP, CHIEF MARKETING OFFICER | -3.72K | $5.84 | -$21.75K | SELL | -3.17% | 113.82K | Aug 21 | View |
| Aug 11, 2023 | Stephen Ray Mitchell | DIRECTOR | -6.50K | $6.05 | -$39.35K | SELL | -18.14% | 29.33K | Aug 10 | View |
| Aug 01, 2023 | Kevin Patrick Moran | SVP, CFO & TREASURER | -2.21K | $6.30 | -$13.94K | SELL | -1.79% | 121.35K | Jul 28 | View |
| Jun 20, 2023 | Kevin Patrick Moran | SVP, CFO & TREASURER | -16.00K | $6.29 | -$100.71K | SELL | -11.46% | 123.56K | Jun 15 | View |
| Jun 15, 2023 | Timothy Williams | SVP & GENERAL COUNSEL | -14.60K | $6.56 | -$95.75K | SELL | -14.10% | 88.91K | Jun 13 | View |
| Mar 06, 2023 | Timothy Williams | SVP & GENERAL COUNSEL | -16.74K | $6.25 | -$104.57K | SELL | -13.92% | 103.51K | Mar 02 - Mar 03 | View |
| Mar 06, 2023 | Joakim Wijkstrom | SVP, CHIEF MARKETING OFFICER | -11.83K | $6.26 | -$74.12K | SELL | -9.15% | 117.54K | Mar 02 - Mar 03 | View |
| Mar 06, 2023 | Mihael Polymeropoulos | PRESIDENT AND CEO | -44.96K | $6.24 | -$280.59K | SELL | -2.95% | 1.48M | Mar 02 - Mar 03 | View |
| Mar 06, 2023 | Kevin Patrick Moran | SVP, CFO & TREASURER | -13.93K | $6.27 | -$87.34K | SELL | -9.08% | 139.56K | Mar 02 - Mar 03 | View |
| Mar 06, 2023 | Gunther Birznieks | SVP, BUSINESS DEVELOPMENT | -16.78K | $6.23 | -$104.58K | SELL | -7.53% | 205.98K | Mar 02 - Mar 03 | View |
| Dec 16, 2022 | Timothy Williams | SVP & GENERAL COUNSEL | -8.00K | $7.01 | -$56.07K | SELL | -8.37% | 87.55K | Dec 15 | View |
| Dec 07, 2022 | Mihael Polymeropoulos | PRESIDENT AND CEO | 54.10K | $6.87 | -$550.28K | SELL-OPTIONS | 4.00% | 1.41M | Dec 05 - Dec 06 | View |
| Dec 07, 2022 | Kevin Patrick Moran | SVP, CFO & TREASURER | 2.71K | $6.86 | -$27.43K | SELL-OPTIONS | 2.29% | 120.80K | Dec 06 | View |
| Aug 23, 2022 | Joakim Wijkstrom | SVP, CHIEF MARKETING OFFICER | -3.60K | $10.27 | -$37.01K | SELL | -3.60% | 96.67K | Aug 22 | View |
| Aug 17, 2022 | Timothy Williams | SVP & GENERAL COUNSEL | -8.30K | $10.30 | -$85.50K | SELL | -7.99% | 95.55K | Aug 15 | View |
| Aug 01, 2022 | Kevin Patrick Moran | SVP, CFO & TREASURER | -2.24K | $10.97 | -$24.56K | SELL | -1.86% | 118.09K | Jul 28 | View |
| Jun 14, 2022 | Stephen Ray Mitchell | DIRECTOR | -2.70K | $9.48 | -$25.59K | SELL | -29.30% | 6.51K | Jun 13 | View |
| Jun 03, 2022 | Thomas Watkins | DIRECTOR | 8.56K | $7.03 | -$1.53K | SELL-OPTIONS | 15.70% | 63.06K | Jun 02 | View |
| Jun 02, 2022 | Richard W Dugan | DIRECTOR | 8.50K | $7.00 | -$1.80K | SELL-OPTIONS | 14.19% | 68.39K | May 31 | View |
| Mar 02, 2022 | Timothy Williams | SVP & GENERAL COUNSEL | 20.64K | $11.09 | -$133.78K | GRANT | 24.80% | 103.85K | Feb 28 - Mar 02 | View |
| Mar 02, 2022 | Joakim Wijkstrom | SVP, CHIEF MARKETING OFFICER | 25.73K | $11.19 | -$78.06K | GRANT | 34.51% | 100.28K | Feb 28 - Mar 02 | View |
| Mar 02, 2022 | Mihael Polymeropoulos | PRESIDENT AND CEO | 77.90K | $11.16 | -$413.96K | GRANT | 6.11% | 1.35M | Feb 28 - Mar 02 | View |
| Mar 02, 2022 | Kevin Patrick Moran | SVP, CFO & TREASURER | 20.39K | $11.26 | -$138.51K | GRANT | 20.41% | 120.33K | Feb 28 - Mar 02 | View |
| Mar 02, 2022 | Gunther Birznieks | SVP, BUSINESS DEVELOPMENT | 17.10K | $11.25 | -$175.49K | GRANT | 9.96% | 188.81K | Feb 28 - Mar 02 | View |
| Dec 02, 2021 | Mihael Polymeropoulos | PRESIDENT AND CEO | 53.80K | $10.57 | -$831.62K | SELL-OPTIONS | 4.41% | 1.27M | Nov 30 - Dec 01 | View |
| Sep 17, 2021 | Aranthan S. Jones II | CHIEF CORP. AFFAIRS OFFICER | -4.71K | $14.07 | -$136.14K | SELL | -5.43% | 81.98K | Sep 15 | View |
| Sep 13, 2021 | Stephen Ray Mitchell | DIRECTOR | 0.00 | $14.39 | -$90.04K | SELL-OPTIONS | 0.00% | 9.21K | Sep 09 | View |
| Aug 23, 2021 | Joakim Wijkstrom | SVP, CHIEF MARKETING OFFICER | -3.65K | $15.39 | -$56.19K | SELL | -4.67% | 74.55K | Aug 20 | View |
| Aug 17, 2021 | Timothy Williams | SVP & GENERAL COUNSEL | -3.71K | $16.15 | -$59.99K | SELL | -4.27% | 83.21K | Aug 16 | View |
| Jul 30, 2021 | Kevin Patrick Moran | SVP, CFO & TREASURER | -2.13K | $19.24 | -$40.97K | SELL | -2.09% | 99.93K | Jul 28 | View |
| Jul 27, 2021 | Aranthan S. Jones II | CHIEF CORP. AFFAIRS OFFICER | -7.25K | $19.69 | -$142.78K | SELL | -7.72% | 86.69K | Jul 26 | View |
| Jun 17, 2021 | Stephen Ray Mitchell | DIRECTOR | -985.00 | $15.00 | -$54.68K | SELL | -9.66% | 9.21K | Jun 15 | View |
| Jun 15, 2021 | Phaedra Chrousos | DIRECTOR | -2.08K | $19.34 | -$40.13K | SELL | -13.83% | 12.93K | Jun 14 | View |
| Mar 16, 2021 | Aranthan S. Jones II | CHIEF CORP. AFFAIRS OFFICER | -3.00K | $14.52 | -$149.21K | SELL | -3.09% | 93.94K | Mar 15 | View |
| Mar 09, 2021 | Mihael Polymeropoulos | PRESIDENT AND CEO | -175.00K | $18.00 | -$3.15M | SELL | -12.54% | 1.22M | Mar 08 | View |
| Mar 08, 2021 | Timothy Williams | SVP & GENERAL COUNSEL | -5.60K | $17.85 | -$99.97K | SELL | -6.05% | 86.93K | Mar 05 | View |
| Mar 03, 2021 | Timothy Williams | SVP & GENERAL COUNSEL | -19.53K | $18.58 | -$362.85K | SELL | -17.43% | 92.53K | Mar 01 - Mar 02 | View |
| Mar 03, 2021 | Joakim Wijkstrom | SVP, CHIEF MARKETING OFFICER | -3.89K | $18.45 | -$71.73K | SELL | -4.74% | 78.20K | Mar 02 | View |
| Mar 03, 2021 | Mihael Polymeropoulos | PRESIDENT AND CEO | -22.68K | $18.38 | -$416.90K | SELL | -1.60% | 1.40M | Mar 01 - Mar 02 | View |
| Mar 03, 2021 | Kevin Patrick Moran | SVP, CFO & TREASURER | -9.37K | $18.35 | -$171.97K | SELL | -8.41% | 102.06K | Mar 01 - Mar 02 | View |
| Mar 03, 2021 | Aranthan S. Jones II | CHIEF CORP. AFFAIRS OFFICER | -3.87K | $18.04 | -$69.72K | SELL | -3.83% | 96.94K | Mar 02 | View |
| Mar 03, 2021 | Gunther Birznieks | SVP, BUSINESS DEVELOPMENT | -20.46K | $18.28 | -$374.02K | SELL | -10.65% | 171.71K | Mar 01 - Mar 02 | View |
| Feb 26, 2021 | Aranthan S. Jones II | CHIEF CORP. AFFAIRS OFFICER | 25.31K | $16.14 | -$183.97K | SELL-OPTIONS | 33.53% | 100.80K | Feb 24 | View |
| Feb 18, 2021 | Thomas Watkins | DIRECTOR | 9.18K | $12.82 | -$1.21K | SELL-OPTIONS | 22.77% | 49.51K | Feb 16 | View |
| Feb 18, 2021 | Richard W Dugan | DIRECTOR | 9.25K | $12.82 | -$13.05 | SELL-OPTIONS | 20.26% | 54.89K | Feb 16 | View |
| Dec 15, 2020 | Mihael Polymeropoulos | — | 24.75K | $10.90 | -$321.01K | OPTION EXERCISE | 1.93% | 1.30M | Dec 11 - Dec 15 | View |
| Aug 21, 2020 | Joakim Wijkstrom | — | -3.71K | $11.08 | -$41.11K | SELL | -6.18% | 56.29K | Aug 20 | View |
| Aug 17, 2020 | Timothy Williams | — | -3.68K | $11.81 | -$43.53K | SELL | -4.44% | 79.36K | Aug 14 | View |
| Aug 14, 2020 | Aranthan S. Jones II | — | -7.20K | $11.81 | -$85.02K | SELL | -8.71% | 75.49K | Aug 12 | View |
| Jul 29, 2020 | Aranthan S. Jones II | — | -7.31K | $10.62 | -$77.63K | SELL | -8.13% | 82.69K | Jul 27 | View |
| Jun 02, 2020 | Thomas Watkins | — | 5.32K | $9.44 | -$585.50 | OPTION EXERCISE | 17.74% | 35.32K | May 29 | View |
| May 29, 2020 | Richard W Dugan | — | 4.87K | $9.21 | -$1.11K | OPTION EXERCISE | 13.62% | 40.64K | May 28 | View |
| Mar 04, 2020 | Timothy Williams | — | -4.38K | $10.36 | -$45.44K | SELL | -5.02% | 83.04K | Mar 02 - Mar 03 | View |
| Mar 04, 2020 | Gian Piero Reverberi | — | -1.45K | $10.18 | -$14.76K | SELL | -0.87% | 165.38K | Mar 02 | View |
| Mar 04, 2020 | Mihael Polymeropoulos | — | -15.58K | $10.70 | -$166.76K | SELL | -1.20% | 1.28M | Mar 02 - Mar 03 | View |
| Mar 04, 2020 | James P. Kelly | — | -18.86K | $10.36 | -$195.45K | SELL | -9.17% | 186.87K | Mar 02 - Mar 03 | View |
| Mar 04, 2020 | Gunther Birznieks | — | -17.76K | $10.23 | -$181.67K | SELL | -10.02% | 159.47K | Mar 02 - Mar 03 | View |
| Jan 06, 2020 | Gian Piero Reverberi | — | -1.16K | $16.06 | -$18.55K | SELL | -0.69% | 166.83K | Jan 02 | View |
| Jan 06, 2020 | Mihael Polymeropoulos | — | -9.47K | $16.00 | -$151.49K | SELL | -0.76% | 1.23M | Jan 02 | View |
| Jan 06, 2020 | James P. Kelly | — | -4.02K | $15.94 | -$64.09K | SELL | -1.92% | 205.73K | Jan 02 | View |
| Jan 06, 2020 | Gunther Birznieks | — | -4.02K | $15.93 | -$64.02K | SELL | -2.66% | 147.23K | Jan 02 | View |
| Dec 13, 2019 | Mihael Polymeropoulos | PRESIDENT AND CEO | 32.59K | $13.80 | -$549.98K | SELL-OPTIONS | 2.69% | 1.24M | Dec 11 - Dec 12 | View |
| Aug 28, 2019 | Richard W Dugan | DIRECTOR | 0.00 | $14.81 | -$1.05K | SELL-OPTIONS | 0.00% | 35.77K | Aug 26 | View |
| Aug 15, 2019 | Timothy Williams | SVP & GENERAL COUNSEL | -2.58K | $14.69 | -$37.83K | SELL | -4.29% | 57.42K | Aug 14 | View |
| May 21, 2019 | Mihael Polymeropoulos | PRESIDENT AND CEO | 32.48K | $13.95 | -$201.23K | SELL-OPTIONS | 2.76% | 1.21M | May 17 - May 21 | View |
| Mar 04, 2019 | Gian Piero Reverberi | SVP & CHIEF COMMERCIAL OFFICER | -881.00 | $20.04 | -$17.66K | SELL | -0.52% | 167.99K | Mar 01 - Mar 04 | View |
| Mar 04, 2019 | Mihael Hristos Polymeropoulos | PRESIDENT AND CEO | -44.67K | $19.53 | -$872.23K | SELL | -3.65% | 1.18M | Mar 01 - Mar 04 | View |
| Mar 04, 2019 | James P. Kelly | EVP & CHIEF FINANCIAL OFFICER | -13.73K | $19.98 | -$274.23K | SELL | -6.14% | 209.75K | Mar 01 - Mar 04 | View |
| Mar 04, 2019 | Gunther Birznieks | SVP, BUSINESS DEVELOPMENT | -12.53K | $19.96 | -$250.09K | SELL | -7.65% | 151.25K | Mar 01 - Mar 04 | View |
| Jan 04, 2019 | Gian Piero Reverberi | SVP & CHIEF COMMERCIAL OFFICER | -1.13K | $26.59 | -$30.04K | SELL | -0.81% | 138.87K | Jan 02 | View |
| Jan 04, 2019 | Gunther Birznieks | SVP, BUSINESS DEVELOPMENT | -6.06K | $26.37 | -$159.81K | SELL | -4.33% | 133.78K | Jan 02 - Jan 03 | View |
| Jan 04, 2019 | James P. Kelly | EVP & CHIEF FINANCIAL OFFICER | -6.06K | $26.37 | -$159.81K | SELL | -3.04% | 193.47K | Jan 02 - Jan 03 | View |
| Jan 04, 2019 | Mihael Hristos Polymeropoulos | PRESIDENT AND CEO | -19.24K | $26.36 | -$401.66K | SELL | -1.63% | 1.16M | Dec 24 - Jan 03 | View |
| Mar 02, 2018 | Mihael Polymeropoulos | PRESIDENT AND CEO | -966.00 | $18.72 | -$1.14M | SELL | -0.08% | 1.18M | Feb 28 - Mar 01 | View |
| Mar 02, 2018 | James Kelly | EVP & CHIEF FINANCIAL OFFICER | 31.47K | $18.72 | -$159.71K | GRANT | 18.72% | 199.53K | Feb 28 - Mar 01 | View |
| Mar 02, 2018 | Richard Gulino | SVP, GENERAL COUNSEL & SEC. | 26.34K | $18.71 | -$68.47K | GRANT | 29.68% | 115.07K | Feb 28 - Mar 01 | View |
| Mar 02, 2018 | Gunther Birznieks | SVP, BUSINESS DEVELOPMENT | 21.48K | $18.72 | -$159.61K | GRANT | 18.14% | 139.84K | Feb 28 - Mar 01 | View |
| Jan 04, 2018 | Mihael Hristos Polymeropoulos | PRESIDENT AND CEO | 91.99K | $10.53 | -$1.49M | SELL-OPTIONS | 8.43% | 1.18M | Dec 28 - Jan 02 | View |
| Jan 04, 2018 | James Patrick Kelly | EVP & CHIEF FINANCIAL OFFICER | 8.35K | $15.35 | -$140.49K | SELL-OPTIONS | 5.22% | 168.07K | Jan 02 | View |
| Jan 04, 2018 | Richard L Gulino | SVP, GENERAL COUNSEL & SEC. | 9.63K | $15.20 | -$157.56K | SELL-OPTIONS | 12.18% | 88.73K | Jan 02 | View |
| Jan 04, 2018 | Gunther Birznieks | SVP, BUSINESS DEVELOPMENT | -8.57K | $15.26 | -$130.78K | SELL | -6.75% | 118.37K | Jan 02 | View |
| Jan 05, 2017 | Paolo Baroldi | SVP & CHIEF MEDICAL OFFICER | 46.30K | $15.51 | $252.78K | SELL-OPTIONS | 574.09% | 54.37K | Jan 03 | View |
| Jan 05, 2017 | Richard L Gulino | SVP, GENERAL COUNSEL & SEC. | 9.10K | $15.51 | -$169.09K | SELL-OPTIONS | ∞ | 9.10K | Jan 03 | View |
| Jan 05, 2017 | James Patrick Kelly | SVP, CFO & TREASURER | 8.95K | $15.51 | -$169.01K | SELL-OPTIONS | 14.73% | 69.72K | Jan 03 | View |
| Jan 05, 2017 | Mihael Hristos Polymeropoulos | PRESIDENT AND CEO | 26.67K | $15.48 | -$361.24K | SELL-OPTIONS | 3.24% | 850.85K | Jan 03 | View |
| Sep 26, 2016 | James FlynnDeerfield Mgmt LPCO MANAGEMENT DEERFIELDDeerfield International Master Fund LPDEERFIELD PARTNERS LPDeerfield Special Situations Fund LP | 10% OWNER | -1.12M | $16.56 | -$18.56M | SELL | -61.78% | 693.17K | Sep 22 - Sep 23 | View |
| Sep 19, 2016 | James FlynnDeerfield Mgmt LPCO MANAGEMENT DEERFIELDDeerfield International Master Fund LPDEERFIELD PARTNERS LPDeerfield Special Situations Fund LP | 10% OWNER | -547.89K | $15.66 | -$8.58M | SELL | -37.33% | 919.72K | Sep 15 - Sep 19 | View |
| Jan 06, 2016 | Mihael Hristos Polymeropoulos | PRESIDENT AND CEO | 22.40K | $8.96 | -$191.32K | SELL-OPTIONS | 2.74% | 839.18K | Jan 04 | View |
| Jan 06, 2016 | James Patrick Kelly | SVP, CFO, SEC & TREASURER | 7.47K | $8.96 | -$85.69K | SELL-OPTIONS | 14.01% | 60.77K | Jan 04 | View |
| Jan 06, 2016 | Paolo Baroldi | SVP & CHIEF MEDICAL OFFICER | 10.12K | $8.96 | -$110.92K | SELL-OPTIONS | 33.13% | 40.66K | Jan 04 | View |
| Dec 18, 2015 | James FlynnDeerfield Mgmt LPCO MANAGEMENT DEERFIELDDeerfield International Master Fund LPDEERFIELD PARTNERS LPDeerfield Special Situations Fund LP | 10% OWNER | 11.17K | $8.97 | $100.16K | BUY | 1.02% | 1.10M | Dec 16 | View |
| Dec 11, 2015 | James FlynnDeerfield Mgmt LPCO MANAGEMENT DEERFIELDDeerfield International Master Fund LPDEERFIELD PARTNERS LPDeerfield Special Situations Fund LP | 10% OWNER | 1.20M | $8.38 | $10.06M | BUY | ∞ | 1.10M | Dec 09 - Dec 11 | View |
| Sep 11, 2015 | Mihael Hristos Polymeropoulos | PRESIDENT AND CEO | 58.63K | $8.71 | -$770.02K | SELL-OPTIONS | 7.73% | 816.78K | Sep 09 - Sep 10 | View |
| May 26, 2015 | Mihael Hristos Polymeropoulos | PRESIDENT AND CEO | 209.23K | $5.35 | -$1.80M | SELL-OPTIONS | 38.12% | 758.15K | May 21 - May 22 | View |
| Mar 12, 2015 | Mihael Hristos Polymeropoulos | PRESIDENT AND CEO | 21.85K | $10.53 | -$230.61K | SELL-OPTIONS | 4.15% | 548.92K | Mar 10 | View |
| Mar 12, 2015 | James Patrick Kelly | SVP, CFO, SEC & TREASURER | 12.08K | $10.53 | -$131.10K | SELL-OPTIONS | 29.31% | 53.30K | Mar 10 | View |
| Mar 12, 2015 | Paolo Baroldi | SVP & CHIEF MEDICAL OFFICER | 8.56K | $10.54 | -$94.23K | SELL-OPTIONS | 38.94% | 30.55K | Mar 10 | View |
| Mar 10, 2015 | Richard W Dugan | DIRECTOR | 5.77K | $7.71 | -$1.29K | SELL-OPTIONS | ∞ | 5.77K | Mar 09 | View |
| Dec 24, 2014 | James FlynnDeerfield Mgmt LPCO MANAGEMENT DEERFIELDDeerfield International Master Fund LPDEERFIELD PARTNERS LP | 10% OWNER | 162.01K | $14.40 | $2.33M | BUY | 8.02% | 2.18M | Dec 23 | View |
| Mar 17, 2014 | Thomas Watkins | DIRECTOR | 0.00 | $13.53 | -$289.17K | SELL-OPTIONS | 0.00% | 0.00 | Mar 14 | View |
| Nov 21, 2013 | Robert Repella | SVP & CHIEF COMMERCIAL OFFICER | -9.38K | $8.48 | -$810.44K | SELL | -38.46% | 15.00K | Nov 19 - Nov 21 | View |
| Nov 21, 2013 | Mihael Hristos Polymeropoulos | PRESIDENT AND CEO | -8.93K | $12.07 | -$107.78K | SELL | -1.86% | 471.64K | Nov 19 | View |
| Nov 21, 2013 | James Patrick Kelly | SVP, CFO, SEC & TREASURER | -3.35K | $12.07 | -$40.42K | SELL | -10.41% | 28.82K | Nov 19 | View |
| Feb 21, 2012 | Mihael Hristos Polymeropoulos | PRESIDENT AND CEO | 19.90K | $4.69 | -$53.25K | SELL-OPTIONS | 4.87% | 428.65K | Feb 16 | View |
| Feb 21, 2012 | James Patrick Kelly | SVP, CFO, SEC & TREASURER | 7.58K | $4.67 | -$22.99K | SELL-OPTIONS | 151.60% | 12.58K | Feb 16 | View |
| Feb 21, 2012 | John Joseph Feeney | SVP & CHIEF MEDICAL OFFICER | 7.43K | $4.65 | -$22.15K | SELL-OPTIONS | 99.03% | 14.93K | Feb 16 | View |
| Aug 30, 2011 | James Patrick Kelly | SVP, CFO, SEC & TREASURER | 5.00K | $5.99 | $29.95K | BUY | ∞ | 5.00K | Aug 29 | View |
| Aug 24, 2011 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | 10.00K | $5.35 | $53.46K | BUY | 2.63% | 390.00K | Aug 22 - Aug 23 | View |
| Dec 13, 2010 | Mihael H. Polymeropoulos | PRESIDENT AND CEO | -100.00K | $8.10 | -$810.28K | SELL | -20.83% | 380.00K | Dec 09 - Dec 10 | View |
| Mar 15, 2010 | Argeris Karabelas | DIRECTOR | -200.00K | $11.80 | -$2.36M | SELL | -100.00% | 0.00 | Mar 12 | View |
| Mar 15, 2010 | David Ramsay | — | -200.00K | $11.80 | -$2.36M | SELL | -100.00% | 0.00 | Mar 12 | View |
| Feb 23, 2010 | William D Clark | SR. VP, CHIEF BUSINESS OFFICER | -9.52K | $10.65 | -$101.41K | SELL | -5.36% | 168.28K | Feb 19 | View |
| Feb 23, 2010 | Stephanie R. Irish | ACTING CFO/TREASURER | -20.00K | $10.59 | -$211.80K | SELL | -89.89% | 2.25K | Feb 19 | View |
| Feb 23, 2010 | John J. Feeney | ACTING CHIEF MEDICAL OFFICER | -20.00K | $10.56 | -$211.20K | SELL | -100.00% | 0.00 | Feb 19 | View |
| Jan 19, 2010 | KEVIN TANGTANG CAPITAL MANAGEMENT LLCTANG CAPITAL PARTNERS LP | 10% OWNER | -54.90K | $10.73 | -$589.18K | SELL | -1.98% | 2.72M | Jan 14 | View |
| Jan 13, 2010 | KEVIN TANGTANG CAPITAL MANAGEMENT LLCTANG CAPITAL PARTNERS LP | 10% OWNER | -149.60K | $10.72 | -$1.60M | SELL | -5.12% | 2.77M | Jan 11 - Jan 13 | View |
| Jan 06, 2010 | KEVIN TANGTANG CAPITAL MANAGEMENT LLCTANG CAPITAL PARTNERS LP | 10% OWNER | -145.50K | $11.60 | -$1.69M | SELL | -4.75% | 2.92M | Jan 04 - Jan 05 | View |
| Dec 16, 2009 | William D Clark | SR. VP, CHIEF BUSINESS OFFICER | 77.80K | $5.69 | -$2.31M | SELL-OPTIONS | 103.73% | 152.80K | Dec 14 | View |
| Dec 16, 2009 | Argeris Karabelas | DIRECTOR | -228.92K | $11.09 | -$2.54M | SELL | -53.37% | 200.00K | Dec 14 - Dec 15 | View |
| Dec 16, 2009 | David R. Ramsay | DIRECTOR | -228.92K | $11.09 | -$2.54M | SELL | -53.37% | 200.00K | Dec 14 - Dec 15 | View |
| Dec 10, 2009 | David R. Ramsay | DIRECTOR | -133.58K | $11.52 | -$1.54M | SELL | -23.75% | 428.92K | Dec 08 - Dec 09 | View |
| Dec 10, 2009 | Argeris Karabelas | DIRECTOR | -133.58K | $11.52 | -$1.54M | SELL | -23.75% | 428.92K | Dec 08 - Dec 09 | View |
| Dec 08, 2009 | David Ramsay | DIRECTOR | -200.00K | $11.63 | -$2.33M | SELL | -26.23% | 562.50K | Dec 04 - Dec 07 | View |
| Dec 08, 2009 | Argeris Karabelas | DIRECTOR | -200.00K | $11.63 | -$2.33M | SELL | -26.23% | 562.50K | Dec 04 - Dec 07 | View |
| Nov 10, 2009 | John J. Feeney | ACTING CHIEF MEDICAL OFFICER | 0.00 | $8.37 | -$55.71K | SELL-OPTIONS | 0.00% | 0.00 | Nov 06 | View |
| Oct 15, 2009 | KEVIN TANGTANG CAPITAL MANAGEMENT LLCTANG CAPITAL PARTNERS LP | 10% OWNER | -600.00K | $12.67 | -$7.60M | SELL | -16.37% | 3.07M | Oct 13 - Oct 15 | View |
| Oct 15, 2009 | Argeris Karabelas | DIRECTOR | -237.50K | $12.65 | -$3.00M | SELL | -23.75% | 762.50K | Oct 13 | View |
| Oct 15, 2009 | David R. Ramsay | DIRECTOR | -237.50K | $12.65 | -$3.00M | SELL | -23.75% | 762.50K | Oct 13 | View |
| May 18, 2009 | John J. Feeney | ACTING CHIEF MEDICAL OFFICER | -6.56K | $12.00 | -$78.74K | SELL | -100.00% | 0.00 | May 18 | View |
| May 14, 2009 | John J. Feeney | ACTING CHIEF MEDICAL OFFICER | -3.00K | $12.21 | -$36.64K | SELL | -31.37% | 6.56K | May 13 | View |
| May 13, 2009 | Stephanie R. Irish | SR. VP, ACTING CFO/TREASURER | 2.45K | $11.19 | -$196.35K | SELL-OPTIONS | ∞ | 2.45K | May 11 - May 13 | View |
| Dec 02, 2008 | KEVIN TANGTANG CAPITAL MANAGEMENT LLCTANG CAPITAL PARTNERS LP | 10% OWNER | 145.00K | $0.73 | $105.53K | BUY | 4.12% | 3.67M | Nov 20 | View |
| Nov 12, 2008 | KEVIN TANGTANG CAPITAL MANAGEMENT LLCTANG CAPITAL PARTNERS LP | 10% OWNER | 560.00K | $0.83 | $464.30K | BUY | 18.91% | 3.52M | Nov 07 | View |
| Sep 29, 2008 | KEVIN TANGTANG CAPITAL MANAGEMENT LLCTANG CAPITAL PARTNERS LP | 10% OWNER | 600.00K | $1.04 | $622.68K | BUY | 11.95% | 5.62M | Sep 25 | View |
| Sep 25, 2008 | KEVIN TANGTANG CAPITAL MANAGEMENT LLCTANG CAPITAL PARTNERS LP | 10% OWNER | 80.00K | $0.98 | $78.52K | BUY | 1.62% | 5.02M | Sep 23 | View |
| Sep 24, 2008 | KEVIN TANGTANG CAPITAL MANAGEMENT LLCTANG CAPITAL PARTNERS LP | 10% OWNER | 100.00K | $1.00 | $99.88K | BUY | 2.07% | 4.94M | Sep 22 | View |
| Sep 23, 2008 | KEVIN TANGTANG CAPITAL MANAGEMENT LLCTANG CAPITAL PARTNERS LP | 10% OWNER | 1.08M | $0.98 | $1.06M | BUY | 28.76% | 4.84M | Sep 19 | View |
| Aug 22, 2008 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 50.00K | $1.13 | $56.75K | BUY | 16.67% | 350.00K | Aug 20 | View |
| Aug 12, 2008 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 118.00K | $1.14 | $134.92K | BUY | 64.84% | 300.00K | Aug 11 | View |
| Aug 11, 2008 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 182.00K | $1.00 | $182.37K | BUY | ∞ | 182.00K | Aug 07 | View |
| Aug 11, 2008 | William D Clark | SR. VP, CHIEF BUSINESS OFFICER | 50.00K | $0.99 | $49.50K | BUY | ∞ | 50.00K | Aug 07 | View |
| Nov 30, 2007 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $5.84 | -$20.84K | SELL-OPTIONS | 0.00% | 0.00 | Nov 28 | View |
| Oct 18, 2007 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $10.31 | -$50.31K | SELL-OPTIONS | 0.00% | 0.00 | Oct 16 | View |
| Oct 03, 2007 | William D Clark | SR. VP, CHIEF BUSINESS OFFICER | 0.00 | $7.10 | -$43.32K | SELL-OPTIONS | 0.00% | 0.00 | Oct 01 | View |
| Sep 20, 2007 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $8.75 | -$40.01K | SELL-OPTIONS | 0.00% | 0.00 | Sep 18 | View |
| Aug 23, 2007 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $8.05 | -$47.27K | SELL-OPTIONS | 0.00% | 0.00 | Aug 21 | View |
| Aug 15, 2007 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 0.00 | $8.13 | -$161.97K | SELL-OPTIONS | 0.00% | 0.00 | Aug 13 | View |
| Aug 03, 2007 | William D Clark | SR. VP, CHIEF BUSINESS OFFICER | 0.00 | $9.58 | -$59.22K | SELL-OPTIONS | 0.00% | 0.00 | Aug 01 | View |
| Jul 19, 2007 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $10.73 | -$65.35K | SELL-OPTIONS | 0.00% | 0.00 | Jul 17 | View |
| Jul 17, 2007 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 0.00 | $10.65 | -$206.29K | SELL-OPTIONS | 0.00% | 0.00 | Jul 16 | View |
| Jun 21, 2007 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $11.01 | -$67.20K | SELL-OPTIONS | 0.00% | 0.00 | Jun 19 | View |
| Jun 12, 2007 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 0.00 | $10.53 | -$204.03K | SELL-OPTIONS | 0.00% | 0.00 | Jun 11 | View |
| Jun 04, 2007 | William D Clark | SR. VP, CHIEF BUSINESS OFFICER | 0.00 | $10.22 | -$63.29K | SELL-OPTIONS | 0.00% | 0.00 | Jun 01 | View |
| May 17, 2007 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $10.11 | -$61.26K | SELL-OPTIONS | 0.00% | 0.00 | May 15 | View |
| May 16, 2007 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 0.00 | $9.86 | -$190.56K | SELL-OPTIONS | 0.00% | 0.00 | May 14 | View |
| Apr 19, 2007 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $11.20 | -$68.48K | SELL-OPTIONS | 0.00% | 0.00 | Apr 17 | View |
| Apr 18, 2007 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 0.00 | $10.92 | -$211.79K | SELL-OPTIONS | 0.00% | 0.00 | Apr 16 | View |
| Apr 03, 2007 | William D Clark | SR. VP, CHIEF BUSINESS OFFICER | 0.00 | $12.23 | -$76.16K | SELL-OPTIONS | 0.00% | 0.00 | Apr 02 | View |
| Mar 21, 2007 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $11.95 | -$73.43K | SELL-OPTIONS | 0.00% | 0.00 | Mar 20 | View |
| Mar 14, 2007 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 0.00 | $11.81 | -$229.49K | SELL-OPTIONS | 0.00% | 0.00 | Mar 12 | View |
| Feb 27, 2007 | Argeris N Karabelas | DIRECTOR | -384.13K | $26.02 | -$9.99M | SELL | -85.69% | 64.17K | Feb 23 | View |
| Feb 27, 2007 | David R. Ramsay | DIRECTOR | -384.13K | $26.02 | -$9.99M | SELL | -85.69% | 64.17K | Feb 23 | View |
| Feb 23, 2007 | Argeris N Karabelas | DIRECTOR | -72.60K | $26.82 | -$1.95M | SELL | -44.97% | 88.83K | Feb 22 | View |
| Feb 23, 2007 | David R. Ramsay | DIRECTOR | -72.60K | $26.82 | -$1.95M | SELL | -44.97% | 88.83K | Feb 22 | View |
| Feb 22, 2007 | David R. Ramsay | DIRECTOR | -437.00K | $27.03 | -$11.81M | SELL | -82.38% | 93.49K | Feb 20 - Feb 21 | View |
| Feb 22, 2007 | Argeris N Karabelas | DIRECTOR | -437.00K | $27.03 | -$11.81M | SELL | -82.38% | 93.49K | Feb 20 - Feb 21 | View |
| Feb 20, 2007 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $14.10 | -$87.59K | SELL-OPTIONS | 0.00% | 0.00 | Feb 20 | View |
| Feb 13, 2007 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 0.00 | $13.88 | -$270.89K | SELL-OPTIONS | 0.00% | 0.00 | Feb 12 | View |
| Feb 01, 2007 | William D Clark | SR. VP, CHIEF BUSINESS OFFICER | 0.00 | $14.92 | -$93.39K | SELL-OPTIONS | 0.00% | 0.00 | Feb 01 | View |
| Jan 18, 2007 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $13.08 | -$80.89K | SELL-OPTIONS | 0.00% | 0.00 | Jan 16 - Nov 16 | View |
| Jan 18, 2007 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 0.00 | $12.97 | -$252.69K | SELL-OPTIONS | 0.00% | 0.00 | Jan 16 | View |
| Dec 14, 2006 | David R. Ramsay | DIRECTOR | -424.15K | $25.18 | -$10.68M | SELL | -77.73% | 121.55K | Dec 12 | View |
| Dec 14, 2006 | CARE CAPITAL II LLCCARE CAPITAL INVESTMENTS II LPCare Capital Offshore Investments II LPJAN LESCHLY | 10% OWNER | -424.15K | $25.18 | -$10.68M | SELL | -77.73% | 121.55K | Dec 12 | View |
| Dec 14, 2006 | Argeris N Karabelas | CHAIRMAN THE BOARD | -424.15K | $25.18 | -$10.68M | SELL | -77.73% | 121.55K | Dec 12 | View |
| Dec 13, 2006 | James B Tananbaum | DIRECTOR | -745.47K | $26.55 | -$19.79M | SELL | -98.54% | 11.04K | Dec 11 - Dec 12 | View |
| Dec 13, 2006 | NICOLE VITULLO | 10% OWNER | -584.29K | $25.62 | -$330.50K | SELL | -96.52% | 21.07K | Dec 12 | View |
| Dec 13, 2006 | ROBERT MORE | 10% OWNER | -584.29K | $25.62 | -$330.50K | SELL | -96.52% | 21.07K | Dec 12 | View |
| Dec 13, 2006 | Kathleen K Schoemaker | 10% OWNER | -584.29K | $25.62 | -$330.50K | SELL | -96.52% | 21.07K | Dec 12 | View |
| Dec 13, 2006 | JESSE TREU | 10% OWNER | -584.29K | $25.62 | -$330.50K | SELL | -96.52% | 21.07K | Dec 12 | View |
| Dec 13, 2006 | BRIAN DOVEY | 10% OWNER | -584.29K | $25.62 | -$330.50K | SELL | -96.52% | 21.07K | Dec 12 | View |
| Dec 13, 2006 | JAMES BLAIR | 10% OWNER | -584.29K | $25.62 | -$330.50K | SELL | -96.52% | 21.07K | Dec 12 | View |
| Dec 13, 2006 | DP VI Associates LP | 10% OWNER | -12.90K | $25.62 | -$330.50K | SELL | -37.98% | 21.07K | Dec 12 | View |
| Dec 13, 2006 | Steven A Shallcross | SR. VP, CFO, TREASURER | 0.00 | $13.64 | -$256.20K | SELL-OPTIONS | 0.00% | 0.00 | Dec 11 | View |
| Dec 13, 2006 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 0.00 | $13.07 | -$3.82M | SELL-OPTIONS | 0.00% | 0.00 | Dec 11 | View |
| Dec 13, 2006 | Deepak Phadke | VICE PRESIDENT MANUFACTURING | 0.00 | $12.83 | -$117.99K | SELL-OPTIONS | 0.00% | 0.00 | Dec 12 | View |
| Dec 13, 2006 | William D Clark | SR VP, CHIEF BUSINESS OFFICER | 0.00 | $13.30 | -$389.22K | SELL-OPTIONS | 0.00% | 0.00 | Dec 11 | View |
| Dec 13, 2006 | David R. Ramsay | DIRECTOR | -326.32K | $26.40 | -$8.61M | SELL | -68.69% | 148.78K | Dec 11 | View |
| Dec 13, 2006 | Argeris N Karabelas | CHAIRMAN THE BOARD | -326.32K | $26.40 | -$8.61M | SELL | -68.69% | 148.78K | Dec 11 | View |
| Dec 13, 2006 | CARE CAPITAL II LLCCARE CAPITAL INVESTMENTS II LPCare Capital Offshore Investments II LPJAN LESCHLY | 10% OWNER | -326.32K | $26.40 | -$8.61M | SELL | -68.69% | 148.78K | Dec 11 | View |
| Dec 01, 2006 | Biomedical Sciences Investment Fund Pte LtdBio One Capital Pte LtdEDB Investments Pte Ltd | 10% OWNER | -590.00K | $15.21 | -$8.98M | SELL | -24.11% | 1.86M | Nov 29 - Nov 30 | View |
| Nov 29, 2006 | David R. Ramsay | DIRECTOR | -300.00K | $14.18 | -$4.25M | SELL | -100.00% | 0.00 | Nov 27 | View |
| Nov 29, 2006 | Argeris N Karabelas | CHAIRMAN THE BOARD | -300.00K | $14.18 | -$4.25M | SELL | -63.87% | 169.73K | Nov 27 | View |
| Nov 29, 2006 | CARE CAPITAL II LLCCARE CAPITAL INVESTMENTS II LPCare Capital Offshore Investments II LPJAN LESCHLY | 10% OWNER | -300.00K | $14.18 | -$4.25M | SELL | -63.87% | 169.73K | Nov 27 | View |
| Nov 27, 2006 | Argeris N Karabelas | CHAIRMAN THE BOARD | -300.00K | $14.12 | -$4.24M | SELL | -61.35% | 188.99K | Nov 22 | View |
| Nov 27, 2006 | David R. Ramsay | DIRECTOR | -300.00K | $14.12 | -$4.24M | SELL | -61.35% | 188.99K | Nov 22 | View |
| Nov 27, 2006 | CARE CAPITAL II LLCCARE CAPITAL INVESTMENTS II LPCare Capital Offshore Investments II LPJAN LESCHLY | 10% OWNER | -300.00K | $14.12 | -$4.24M | SELL | -61.35% | 188.99K | Nov 22 | View |
| Nov 22, 2006 | David R. Ramsay | DIRECTOR | -50.00K | $14.55 | -$727.50K | SELL | -19.36% | 208.25K | Nov 21 | View |
| Nov 22, 2006 | CARE CAPITAL II LLCCARE CAPITAL INVESTMENTS II LPCare Capital Offshore Investments II LPJAN LESCHLY | 10% OWNER | -50.00K | $14.55 | -$727.50K | SELL | -19.36% | 208.25K | Nov 21 | View |
| Nov 22, 2006 | Argeris N Karabelas | CHAIRMAN THE BOARD | -50.00K | $14.55 | -$727.50K | SELL | -19.36% | 208.25K | Nov 21 | View |
| Nov 21, 2006 | David R. Ramsay | DIRECTOR | -320.00K | $14.41 | -$4.61M | SELL | -50.75% | 310.50K | Nov 17 - Nov 20 | View |
| Nov 21, 2006 | Argeris N Karabelas | CHAIRMAN THE BOARD | -320.00K | $14.41 | -$4.61M | SELL | -50.75% | 310.50K | Nov 17 - Nov 20 | View |
| Nov 21, 2006 | CARE CAPITAL II LLCCARE CAPITAL INVESTMENTS II LPCare Capital Offshore Investments II LPJAN LESCHLY | 10% OWNER | -320.00K | $14.41 | -$4.61M | SELL | -50.75% | 310.50K | Nov 17 - Nov 20 | View |
| Nov 21, 2006 | Biomedical Sciences Investment Fund Pte LtdBio One Capital Pte LtdEDB Investments Pte Ltd | 10% OWNER | -100.00K | $15.02 | -$1.50M | SELL | -3.93% | 2.45M | Nov 17 - Nov 20 | View |
| Nov 17, 2006 | RHO VENTURES IV LPRHO VENTURES IV QP LPKG BETEILIGUNGS CO GMBH VENTURES RHO IVGMBH VERWALTUNGS PARTNERS CAPITAL RHORHO MANAGEMENT VENTURES IV LLCRHO CAPITAL PARTNERS INCJOSHUA RUCHHABIB KAIROUZMARK LESCHLYTRUST MANAGEMENT RHO | 10% OWNER | -540.00K | $14.98 | -$8.09M | SELL | -22.47% | 1.86M | Nov 15 | View |
| Nov 16, 2006 | Biomedical Sciences Investment Fund Pte LtdBio One Capital Pte LtdEDB Investments Pte Ltd | 10% OWNER | -25.71K | $15.13 | -$389.05K | SELL | -1.00% | 2.55M | Nov 15 | View |
| Nov 09, 2006 | RHO VENTURES IV LPRHO VENTURES IV QP LPKG BETEILIGUNGS CO GMBH VENTURES RHO IVGMBH VERWALTUNGS PARTNERS CAPITAL RHORHO MANAGEMENT VENTURES IV LLCRHO CAPITAL PARTNERS INCJOSHUA RUCHHABIB KAIROUZMARK LESCHLYTRUST MANAGEMENT RHO | 10% OWNER | 0.00 | $11.79 | -$158.82K | ACQ/DIS | 0.00% | 2.40M | Nov 06 | View |
| Nov 08, 2006 | William D Clark | SR VP, CHIEF BUSINESS OFFICER | -6.30K | $11.55 | -$72.79K | SELL | -100.00% | 0.00 | Nov 08 | View |
| Nov 08, 2006 | William D Clark | SR VP, CHIEF BUSINESS OFFICER | 6.30K | $5.74 | -$135.32K | SELL-OPTIONS | ∞ | 6.30K | Nov 07 - Nov 08 | View |
| Nov 08, 2006 | Mihael H. Polymeropoulos | CHIEF EXECUTIVE OFFICER | 0.00 | $6.06 | -$198.71K | SELL-OPTIONS | 0.00% | 0.00 | Nov 06 - Nov 07 | View |
