Discovery Laboratories, Inc.
DSCO today announced the presentation of the last in a series of
pharmacoeconomic analyses indicating that a reduction in the rate of
reintubation ^ among preterm infants may potentially result in hospital
cost-savings related to fewer reintubation-related diagnoses of
bronchopulmonary dysplasia (BPD), air leak, sepsis, necrotizing enterocolitis
(NEC), or intraventricular hemorrhage (IVH), including savings of up to
$562,000 per 100 patients diagnosed with BPD. The pharmacoeconomic model was
developed using an observation from a previously published study that preterm
infants who receive SURFAXIN® may have lower rates of reintubation when
compared with preterm infants who received either Curosurf® ^ or Survanta®.
The findings from this third and final pharmacoeconomic analysis were
presented recently at the 2013 Pediatric Pharmacy Advocacy Group (PPAG) Annual
Meeting held in Indianapolis, IN.
Inpatient hospital costs for treating neonates with the primary diagnoses of
BPD, air leak, sepsis, NEC, or IVH was obtained from a 2009 database of more
than seven million U.S. hospital discharges, and multiplied by the intubation
rate observed in each surfactant treatment group and the incidence of each
morbidity in reintubated infants. The model compared projected costs between
the SURFAXIN treatment group and the comparator surfactant treatment groups
from two phase 3 trials, SELECT and STAR, and yielded potential differences in
hospital costs per 100 patients ranging from $34,000 for air leak alone to
$562,000 for BPD (Figure 1).
Discovery Labs expects to submit this analysis to a peer-reviewed,
neonatology-focused medical journal later this year.
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