Benzinga’s Top Pre-Market Gainers (RYAAY, AMAG, XRTX, KMX)

Ryanair Holdings plc (ADR) (NASDAQ: RYAAY) rose 6.37% to $28.90 in the pre-market session. Ryanair Holdings lifted its annual profit guidance today. Ryanair Holdings now expects to make no less than 310 million euros ($418 million) in the year ended March 31, 2010. The 52-week trading range for RYAAY is $22.79 - $31.92. In the last six months, RYAAY has declined over 6%.

AMAG Pharmaceuticals, Inc. (NASDAQ: AMAG) climbed 6.53% to $37.19 in the pre-market session. AMAG Pharmaceuticals, Inc. and Takeda Pharmaceutical Company Limited jointly announced that the companies have entered into a license, development and commercialization agreement related to Feraheme (ferumoxytol) Injection for intravenous (IV) use in all therapeutic indications. In the previous trading session, AMAG closed at $34.91. AMAG has declined over 5% in the last year.

Xyratex Ltd. (NASDAQ: XRTX) jumped 12.82% to $19.10 in the pre-market session. Xyratex Group Limited announced that for the second quarter of 2010, it expects revenue to be in the range $400 to $460 million, fully diluted earnings per share to be between $1.00 and $1.53 on a GAAP basis and fully diluted EPS on a non-GAAP basis to be between $1.10 and $1.63. The 52-week trading range for XRTX is $2.07 - $18.47. Xyratex closed at $16.93 in the last trading session.

CarMax, Inc (NYSE: KMX) gained 2.59% to $25.77 in the pre-market session. CarMax reported today a fourth-quarter profit of $75.4 million, or $0.33 per share, from $37.5 million, or $0.17 per share, in the year ago period. Analysts expected KMX to earn $0.25 per share on sales of $1.77 billion. In the last trading session, KMX closed at $25.12.