Single Dose Of ImmunityBio's Dual Antigen COVID-19 Vaccine Induces Ten-Fold Increase In T-Cell Responses

ImmunityBio Inc IBRX has reported initial data from the Phase 1 study evaluating its hAd5 COVID-19 vaccine candidate in healthy participants.
Just 14-16 days after the single dose of the vaccine, the mean level of T cells generated in response to dual antigen hAd5 spike (S) + nucleocapsid (N) vaccine was ten times higher for N specific T cells.
By day 21, both S and N T cell responses achieved levels ten times higher than pre-vaccination levels.
Data also indicated that the hAd5 S+N vaccine could provide protection against both the first wave SARS-CoV-2 and variants.
The mean T cell levels seen in the vaccinated participants were equivalent to those for patients recovered from infection by the SARS-CoV-2 virus.
This second-generation hAd5 vectored vaccine targets both spike (S) and nucleocapsid (N) SARS-CoV-2 proteins to generate B and T cell memory to these antigens and long-term immunity to the virus.
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