Vaccinex Initiates Pepinemab Trials for Alzheimer's, Head & Neck Cancer

  • Vaccinex Inc VCNX has activated first clinical sites to screen and enroll patients in its Phase 1/2 study evaluating pepinemab as a single agent in Alzheimer's disease (AD) and in its phase 2 study in combination with Merck & Co Inc's MRK Keytruda (pembrolizumab) for advanced, recurrent or metastatic head and neck squamous cell carcinoma (HNSCC).
  • The Alzheimer's proof-of-concept study is expected to enroll at least 40 patients with key efficacy endpoints that include cognition and brain imaging measures.
  • This study has received funding support from the Alzheimer's Drug Discovery Foundation and the Alzheimer's Association.
  • The HNSCC study will enroll up to 65 patients. Efficacy endpoints will focus on objective response rate and progression-free survival, overall survival, and duration of response.
  • Price Action: VCNX shares are up 5% at $3.15 during the premarket session on the last check Tuesday.
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