Moderna Takes Its First Autoimmune Therapeutic Candidate To Human Trial

  • Moderna Inc MRNA has dosed the first patient in the Phase 1 study of mRNA-6231, its mRNA-encoded IL-2 modified to expand regulatory T cells. 
  • mRNA-6231 is Moderna's first autoimmune candidate to enter the clinic. It is also Moderna's first subcutaneously administered therapeutic program.
  • The trial will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of mRNA‑6231 in healthy adult participants.
  • mRNA‑6231 is a lipid nanoparticle encapsulated mRNA-based therapeutic that encodes for mutein human interleukin 2, fused to human serum albumin (HSA‑IL2m) to achieve enhanced selectivity toward T regulatory cells. 
  • IL-2 through preferential expansion of Tregs is hypothesized to play a central role in restoring immune homeostasis.
  • Price Action: MRNA shares are down 0.51% at $351.80 during the market session on the last check Monday.
Market News and Data brought to you by Benzinga APIs
Comments
Loading...
Posted In: BiotechNewsHealth CareGeneralautoimmune diseasesBriefs
Benzinga simplifies the market for smarter investing

Trade confidently with insights and alerts from analyst ratings, free reports and breaking news that affects the stocks you care about.

Join Now: Free!