Why Are Teva And Sanofi Stocks Trading Higher On Tuesday?

Zinger Key Points
  • In UC, duvakitug achieved 27.4% placebo-adjusted clinical remission at high dose vs. 15.7% at low dose in 14 weeks.
  • In CD, duvakitug's high dose showed 34.8% placebo-adjusted endoscopic response vs. 13.0% at low dose.

On Tuesday, Teva Pharmaceutical Industries Ltd. TEVA and Sanofi SA’s SNY Phase 2b RELIEVE UCCD study met its primary endpoints in patients with ulcerative colitis (UC) and Crohn’s disease (CD).

RELIEVE UCCD investigated duvakitug (TEV’574/SAR447189), a human IgG1-λ2 monoclonal antibody targeting TL1A, for moderate-to-severe inflammatory bowel disease (IBD).

In the RELIEVE UCCD study, 36.2% (low-dose) and 47.8% (high-dose) of patients with ulcerative colitis treated with duvakitug achieved clinical remission compared to 20.45% on placebo, placebo-adjusted rates were 15.7% (low dose) and 27.4% (high dose), at week 14.

Also Read: Amicus Therapeutics Settles Patent Lawsuit Teva Pharmaceuticals Over Generic Version Of Its Rare Genetic Disorder Drug

In patients with Crohn’s disease, 26.1% (low-dose) and 47.8% (high-dose) treated with duvakitug achieved endoscopic response compared to 13.0% on placebo, placebo-adjusted rates were 13.0% (low dose) and 34.8% (high dose).

Overall, the treatment effect was consistent across subgroups.

Detailed results are expected to be presented at a scientific forum in 2025.

Duvakitug was generally well tolerated in ulcerative colitis and Crohn’s disease, with no safety signal identified.

Overall treatment-emergent adverse events (AE) rates were similar between duvakitug and placebo.

Ulcerative colitis and Crohn’s disease, the two main types of IBD, are chronic inflammatory conditions of the GI tract resulting in symptoms such as abdominal pain, diarrhea, rectal bleeding, fatigue, and weight loss.

Price Action: At last check Tuesday, TEVA stock was up 20.40% at $19.88, and SNY stock was up 4.07% at $47.76 during the premarket session.

Read Next:

Market News and Data brought to you by Benzinga APIs
Comments
Loading...
Posted In:
Benzinga simplifies the market for smarter investing

Trade confidently with insights and alerts from analyst ratings, free reports and breaking news that affects the stocks you care about.

Join Now: Free!