U.S. stocks were lower, with the Dow Jones index falling around 350 points on Wednesday.

Shares of Gilead Sciences, Inc. GILD rose sharply during Wednesday's session after the company reported better-than-expected fourth-quarter financial results and issued FY25 adjusted EPS guidance above estimates.

Gilead Sciences reported quarterly earnings of $1.90 per share which beat the analyst consensus estimate of $1.70. Quarterly revenue came in at $7.56 billion which beat the analyst consensus estimate of $7.13 billion and is an increase over revenue of $7.11 billion from the same period last year.

Gilead Sciences shares jumped 8.1% to $103.88 on Wednesday.

Here are some other big stocks recording gains in today's session.

  • Upstart Holdings, Inc. UPST shares jumped 30.7% to $88.07 after the company reported better-than-expected fourth-quarter financial results and issued FY25 revenue guidance above estimates. Multiple analysts upgraded the stock following the report.
  • AnaptysBio, Inc. ANAB rose 19.6% to $14.82 after the company announced statistically significant week 12 data from the Phase 2b trial of rosnilimab in moderate-to-severe rheumatoid arthritis.
  • Mercury General Corporation MCY gained 17.4% to $58.80 after the company reported quarterly financial results. Raymond James upgraded the stock from Outperform to Strong Buy and raised its price target from $70 to $80.
  • EHang Holdings Limited EH rose 16.5% to $24.13.
  • Confluent, Inc. CFLT gained 15.5% to $34.78 after the company reported better-than-expected fourth-quarter financial results.
  • Angi Inc. ANGI surged 15% to $1.9850 following better-than-expected fourth-quarter sales and a year-over-year increase in EPS results.
  • CVS Health Corporation CVS climbed 14.6% to $63.05 after the company reported quarterly earnings and revenue above estimates.
  • Calumet, Inc. CLMT gained 13.3% to $18.00.
  • The Chefs’ Warehouse, Inc. CHEF gained 11.3% to $60.69 following better-than-expected quarterly reported financial results.
  • Sensata Technologies Holding plc ST surged 9.2% to $28.05 following a fourth-quarter adjusted EPS and revenue beat.
  • iQIYI, Inc. IQ gained 9.2% to $2.50.
  • VNET Group, Inc. VNET rose 8.5% to $10.82.
  • CRISPR Therapeutics AG CRSP gained 8.4% to $42.95  after the company reported better-than-expected quarterly financial results and Barclays raised its price target on the stock from $55 to $56.
  • Prudential plc PUK gained 6.1% to $18.10.
  • IAC Inc. IAC surged 5.6% to $43.31 following strong quarterly sales.

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