Senesco Technologies Announces Positive Results Related to Multiple Myeloma

Senesco Technologies

announced today that the combination of bortezomib (the active component of VELCADE^® marketed by Millennium, The Takeda Oncology Company) and SNS01-T, the subject of Senesco's on-going multiple myeloma clinical study, performs significantly better than either treatment alone in mouse xenograft models. “We are very pleased to have shown that SNS01-T enhances the ability of bortezomib to inhibit tumor growth in the mouse model and could be a way to lower the dose and reduce the severity of treatment-related side effects of bortezomib ,” said Leslie J. Browne, Ph.D., President and CEO of Senesco. Dr. Browne added, “Since treatment increasingly involves combination therapy, it is important that SNS01-T works well when added to current multiple myeloma drugs.” Mice implanted in the flank with human myeloma RPMI 8226 cells were treated with SNS01-T (0.375 mg/Kg IV), one of two different dose levels of bortezomib (0.2, 0.5 mg/Kg IP) alone or in combination with SNS01-T (0.375 mg/Kg IV). SNS01-T and bortezomib were administered twice weekly for 6 weeks. The study used an inactive nanoparticle as the control. SNS01-T monotherapy achieved 59% tumor growth inhibition, which exceeded that of bortezomib alone at either the 0.2 mg/kg dose (22% inhibition) or at 0.5 mg/kg (39 % inhibition). However, the combination of SNS01-T with 0.5 mg/kg of bortezomib resulted in 89 % tumor inhibition which was significantly more effective than either SNS01-T or bortezomib alone.