SpringWorks Therapeutics Stock Is Trading Higher After Nirogacestat Combo Study Starts Dosing In Multiple Myeloma Patients

  • SpringWorks Therapeutics Inc SWTX has dosed the first patient in a Phase 1b clinical trial evaluating nirogacestat combined with Johnson & Johnson's JNJJanssen's teclistamab in patients with relapsed or refractory multiple myeloma.
  • Nirogacestat is an investigational gamma-secretase inhibitor (GSI) developed by SpringWorks.
  • Teclistamab, an investigational bispecific antibody, targets B-cell maturation antigen (BCMA) and CD3.
  • Gamma secretase inhibition prevents the cleavage and shedding of BCMA from the surface of myeloma cells.
  • Janssen conducts the Phase 1b trial, which is part of a multi-arm trial, and an open-label study to evaluate the safety, tolerability, and preliminary efficacy of the nirogacestat combo.
  • The trial is being advanced under a clinical collaboration and supply agreement that SpringWorks entered into with Janssen in September last year.
  • Under the terms of the agreement, Janssen will be responsible for all the Phase 1b study costs.
  • SpringWorks has formed a joint oversight committee with Janssen to coordinate the sharing of study results, regulatory and other activities connected with the study.
  • Price Action: SWTX shares are trading 7.1% higher at $73.57 in the premarket trading on the last check Thursday.
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Posted In: BiotechNewsHealth CareGeneralJanssen Pharmaceuticalsmultiple myeloma
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