BioLineRx Stock Is Trading Higher As Motixafortide-G-CSF Combo Shows Promise In Transplant Setting For Multiple Myeloma Patients

BioLineRx BLRX has announced positive top-line results from GENESIS Phase 3 trial evaluating its lead clinical candidate, Motixafortide, combined with granulocyte colony-stimulating factor (G-CSF), for hematopoietic stem-cell mobilization for autologous bone marrow transplantation in multiple myeloma patients.
An analysis of data on all 122 enrolled patients found highly statistically significant evidence across all primary and secondary endpoints favoring Motixafortide in addition to G-CSF, as compared to placebo plus G-CSF.
The primary endpoint of the study demonstrated a 4.9-fold increase (70.0% vs. 14.3%; difference 54.6%) in the proportion of patients in the treatment arm, as compared to the control arm, mobilizing over 6 million CD34+ cells/kg in up to two apheresis sessions and after only one administration of Motixafortide.
The study also achieved its secondary endpoint, demonstrating a 14.1-fold increase (67.5% vs. 4.8%; difference 61.7%) in the proportion of patients in the treatment arm, as compared to the control arm, which mobilized over 6 million CD34+ cells/kg in just one apheresis session.
A 5.6 fold increase was observed in the median number of CD34+ cells collected on the first day of apheresis (8.5 million in the treatment arm vs. 1.5 million in the control arm).
The addition of Motixafortide to G-CSF also allowed 88.3% of patients to undergo transplantation after only one apheresis session, compared to 10.8% in the G-CSF arm.
BioLineRx will hold a conference call today at 10:00 a.m. ET.
Price Action: BLRX shares are up 75.9% at $5.62 in the premarket session on the last check Tuesday.

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