Altimmune's Intranasal COVID-19 Vaccine Candidate Shows Sterilizing Immunity After Single Dose

Altimmune Inc ALT has announced positive results from a preclinical study evaluating its intranasal COVID-19 vaccine candidate, AdCOVID, in a SARS-CoV-2 challenge model of infection.
The results showed that a single dose of AdCOVID provided sterilizing immunity in the lungs of vaccinated mice, in contrast to the development of dense pulmonary infection and disease in the lungs of non-vaccinated mice following infection with SARS-CoV-2.
No detectable levels of infectious virus were observed in the lungs of vaccinated mice, representing a greater than one million-fold reduction compared to the non-vaccinated controls.
The ongoing Phase 1 trial evaluates the safety and immunogenicity of AdCOVID following a single dose or two intranasal doses administered one month apart.
Topline data is expected next month.
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