- Mustang Bio Inc MBIO and the City of Hope, an independent cancer research and treatment center, have dosed the first patient in Phase 1 trial evaluating MB-101 in patients with leptomeningeal brain tumors.
- The trial will enroll up to 30 patients and determine the safety and feasibility of administering MB-101 through the ICV Rickham catheter over four weekly cycles in patients with glioblastoma (Arm 1) and ependymoma or medulloblastoma (Arm 2).
- The primary endpoints being evaluated are toxicity, and the survival at three months.
- Secondary endpoints include overall survival, CAR T and endogenous T cell levels, cytokine levels and phenotype detection in peripheral blood, tumor cyst fluid, and cerebrospinal fluid.
- Analyst Update: BTIG initiated coverage on Mustang Bio with Buy Rating, with a Price Target of $11 (upside of around 260%)
- Price Action: MBIO shares are up 5.59% at $3.02 during the premarket session on the last check Tuesday.
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