Oncolytics Pelareorep/Pembrolizumab Combo Therapy Shows Anti-Cancer Activity In Pancreatic Cancer

  • Oncolytics Biotech Inc ONCY has announced new data from Phase 2 trial evaluating pelareorep in combination with Merck & Co Inc MRK Keytruda (pembrolizumab) in pancreatic cancer.
  • Data will be presented at the 2021 American Society of Clinical Oncology Annual Meeting.
  • Findings from the trial indicate that pelareorep and pembrolizumab synergize and show anti-cancer activity in patients who progressed after first-line treatment.
  • Disease control was achieved in 42% (5/12) of patients, with one patient achieving a partial response and four patients achieving stable disease.
  • On-treatment tumor biopsies showed pelareorep replication and increased infiltration of CD8+ T cells and PD-L1+ cells relative to pre-treatment samples.
  • Patients achieving disease control showed reductions in pro-tumor regulatory T cells and increased activation of anti-cancer CD8+ T cells compared to those with progressive disease.
  • Pelareorep-pembrolizumab combination therapy was found to be well tolerated, with most treatment-related adverse events being mild or moderate.
  • Price Action: ONCY shares are up 5.8% at $2.99 during the market session on the last check Thursday.
  • Related content: Benzinga's Full FDA Calendar
Market News and Data brought to you by Benzinga APIs
Comments
Loading...
Posted In: BiotechNewsPenny StocksHealth CareMoversTrading IdeasGeneralBriefsPancreatic Cancer
Benzinga simplifies the market for smarter investing

Trade confidently with insights and alerts from analyst ratings, free reports and breaking news that affects the stocks you care about.

Join Now: Free!