Hoth Therapeutics Unveils Preclinical Results of HT-KIT Therapeutic Program

  • Hoth Therapeutics Inc HOTH has reported results from a preclinical trial of HT-KIT, a new molecular entity under development to treat mast cell-derived cancers and anaphylaxis.
  • HT-KIT is an mRNA frame-shifting therapeutic designed to specifically target the receptor tyrosine kinase KIT, which is required for the proliferation, survival, and differentiation of bone marrow-derived hematopoietic stem cells.
  • Key findings of the mouse models found that HT-KIT:
    • Reduces KIT expression and induces apoptosis of neoplastic human mast cells.
    • Inhibits tumor growth in humanized xenograft mast cell neoplasia models.
    • Reduces liver infiltration of neoplastic mast cells.
    • Reduces tumor growth in isograft models of mast cell neoplasia.
    • Reduces signs of mast cell leukemia in an isograft model of mutant mast cell neoplasia.
  • Price Action: HOTH shares are up 2.29% at $1.57 during the market session on the last check Thursday.
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