Chinook Therapeutics' BION-1301 Shows Reduction In 24-Hour Proteinuria In Nephropathy Trial

Chinook Therapeutics Inc KDNY has announced interim data from the ongoing Phase 1/2 study of BION-1301 in patients with IgA Nephropathy (IgAN).
The findings were presented at the 58th European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Virtual Congress.
BION-1301 has demonstrated a clinically meaningful mean reduction in 24-hour proteinuria.
The candidate has been well-tolerated, with no treatment-related adverse events, SAEs, infusion-related reactions, or treatment discontinuations due to adverse events.
To date, no anti-drug antibodies have been observed in patients.
BION-1301 has durably reduced serum IgA and IgM levels and, to some extent, IgG levels.
The treatment has also resulted in significant and sustained reductions in Gd-IgA1, demonstrating depletion of the pathogenic IgA variant.
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