Crinetics' Single Ascending Dose Data Shows Proof Of ACTH Antagonism In Healthy Volunteers

Crinetics Pharmaceuticals Inc CRNX announced preliminary findings from the single ascending dose (SAD) portion of Phase 1 study evaluating CRN04894 for conditions of ACTH excess, including Cushing's disease and congenital adrenal hyperplasia.
The data demonstrated pharmacologic proof-of-concept for this nonpeptide adrenocorticotropic hormone (ACTH) antagonist.
The 39 healthy volunteers were administered oral doses of CRN04894 (10 mg to 80 mg, or placebo) two hours before a challenge with synthetic ACTH.
Analyses of basal cortisol levels (before the ACTH challenge) showed that CRN04894 produced a rapid and dose-dependent reduction of cortisol by 25-56%.
After the challenge with a supra-pathophysiologic dose of ACTH (250 mcg), CRN04894 suppressed cortisol up to 41%.
After the challenge with a disease-relevant dose of ACTH (1 mcg), CRN04894 showed a clinically meaningful reduction in cortisol AUC of 48%.
CRN04894 was well tolerated in the healthy volunteers who enrolled in these SAD cohorts, and all adverse events were considered mild.
Unrestricted cash, cash equivalents, and investments as of June 30, 2021, totaled $203.8 million.
Price Action: CRNX shares closed higher by 4.27% at $17.60 on Tuesday.

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