AstraZeneca's Imfinzi / Tremelimumab Combo Regime Shows Survival Benefit In Lung Cancer Settings

POSEIDON Phase 3 trial results showed AstraZeneca Plc's AZN Imfinzi (durvalumab), tremelimumab, and chemotherapy, extended survival in lung cancer patients.
The combo therapy topped overall survival (OS) and progression-free survival (PFS), chemotherapy alone in 1st-line treatment of patients with Stage IV (metastatic) non-small cell lung cancer (NSCLC).
Patients treated with a short course of five cycles of tremelimumab over 16 weeks in addition to Imfinzi and chemo experienced a 23% reduction in the risk of death versus a range of chemotherapy.
Median OS was 14.0 months versus 11.7 months for chemotherapy. An estimated 33% of patients were alive at two years versus 22% for chemotherapy.
The treatment combination also reduced the risk of disease progression or death by 28% compared to chemotherapy alone, with a median PFS of 6.2 months versus 4.8 months, respectively.
The trial also tested a combination of Imfinzi plus chemotherapy, which, while showing a statistically significant improvement in PFS versus chemotherapy, failed to improve OS significantly.
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