Takeda In-Licenses Hunter Syndrome Candidate

  • Takeda Pharmaceutical Company Limited TAK and JCR Pharmaceuticals Co Ltd have announced an exclusive collaboration and license agreement to commercialize JR-141 (pabinafusp alfa) for Hunter syndrome (Mucopolysaccharidosis type II or MPS II).
  • JR-141 is an investigational, next-generation recombinant fusion protein of an antibody against the human transferrin receptor and iduronate-2-sulfatase (IDS) enzyme. 
  • Hunter syndrome is a rare, inherited disorder in which the body does not correctly digest sugar molecules, resulting in the buildup of unbroken molecules in organs and tissues. 
  • Under the agreement terms, Takeda will exclusively commercialize JR-141 outside the U.S., including Canada, Europe, and other regions (excluding Japan and certain other Asia-Pacific countries). 
  • JCR will receive an upfront payment and is eligible to receive additional milestone payments and tiered sales-based royalties.
  • Specific deal terms were not disclosed.
  • Takeda also received an option under a separate option agreement, allowing Takeda to acquire an exclusive license to commercialize JR-141 in the U.S. upon completing the Phase 3 program.
  • Price Action: TAK stock traded 0.92% higher at $16.46 premarket on the last check Thursday.
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Posted In: BiotechNewsHealth CareContractsGeneralBriefsHunter Syndrome
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