Turning Point Shares Plunge After Highlighting Updated Data From Lead Program In Pretreated Lung Cancer Patients

  • Turning Point Therapeutics Inc TPTX has announced additional preliminary data from ongoing trials of lead drug candidate repotrectinib and elzovantinib (TPX-0022). 
  • The data were presented at the Virtual International Conference on Molecular Targets and Cancer Therapeutics.
  • Repotrectinib demonstrated clinical activity across multiple ROS1+ TKI-pretreated NSCLC Cohorts, with confirmed objective response rates (cORR) of 30%-39% in the TRIDENT-1 Study.
  • Repotrectinib showed a cORR of 53% in ROS1+ TKI-Pretreated NSCLC Patients with G2032R Solvent Front Mutation.
  • At the anticipated meeting with the FDA in 1H of 2022, Turning Point plans to discuss available BICR data in at least 50 patients from the ROS1-positive TKI-pretreated NSCLC cohorts of the study.
  • Elzovantinib (TPX-0022) achieved cORR of 36% and 33%, respectively, in MET TKI-Naïve NSCLC and Gastric / Gastroesophageal Junction Cancer Patients Harboring Genetic Alterations in MET in SHIELD-1 Study.
  • Related: Turning Point's TPX-0022 In Gastric Cancer Gets Orphan Drug Designation In US.
  • For Elzovantinib, based on the FDA feedback, the Company plans to revise SHIELD-1 into a potentially registrational Phase 1/2 study and initiate the Phase 2 portion of SHIELD-1 in 2022, pending FDA feedback on data from the intermediate dose level.
  • Price Action: TPTX shares are down 15.3% at $51.42 during the market session on the last check Thursday.
Market News and Data brought to you by Benzinga APIs
Comments
Loading...
Posted In:
Benzinga simplifies the market for smarter investing

Trade confidently with insights and alerts from analyst ratings, free reports and breaking news that affects the stocks you care about.

Join Now: Free!