Moderna Posts Interim Data From mRNA Triplet Program In Solid Tumors

  • Moderna Inc MRNA announced interim data from Phase 1 study of mRNA-2752 (Triplet) in patients with accessible solid tumors and lymphomas. 
  • The data showed that the mRNA Triplet program given in combination with AstraZeneca Plc's AZN Imfinzi (durvalumab) was tolerated at all dose levels and elicited evidence of anti-tumor activity. 
  • The recommended dose for expansion (RDE) is up to 8mg mRNA-2752 + durvalumab.
  • The data were presented at the Society for Immunotherapy of Cancer's (SITC) Annual Meeting.
  • The study consists of dose escalation and dose confirmation parts, which will occur in Arm A and Arm B, followed by a dose expansion part, which will occur in Arm B, and a Dose Exploration in Arm C as neoadjuvant therapy for cutaneous melanoma. 
  • Enrollment in the dose-expansion part of Arm B and Arm C is currently ongoing.
  • Price Action: MRNA shares are down 0.42% at $230.22 during the premarket session on the last check Monday.
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Posted In: BiotechNewsHealth CareGeneralBriefsPhase 1 TrialSolid Tumor
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