Arbutus' Hepatitis B Candidate Shows Encouraging Antiviral Activity

  • Arbutus Biopharma Corporation ABUS has announced preliminary data from its Phase 1a/1b trial of AB-836, an oral hepatitis B virus (HBV) capsid inhibitor that interacts with HBV core protein, which in turn is required for viral replication.
  • Arbutus shares are soaring after the Patent Trial and Appeals Board has turned down Moderna Inc's MRNA appeal to invalidate two of Arbutus' patents on the COVID-19 Vaccine Delivery Technology Patent.
  • AB-836 is generally safe and well-tolerated in healthy subjects and patients with cHBV and provides the robust antiviral activity.
  • One healthy subject who received 50mg once daily discontinued after treatment on day 13 due to agitation's adverse event (AE). 
  • All but three AEs were mild, and only one was assessed as related to AB-836 (Grade 1 rash). 
  • Arbutus continues to enroll and dose cHBV patients in Part 3 of the clinical trial and anticipates presenting additional data at a medical conference in 2022.
  • Related Link: Arbutus Biopharma, Vaccitech Team Up To Develop Combo Treatment For Hepatitis B.
  • Price Action: ABUS shares are up 58.6% at $5.01 during the market session on the last check Wednesday.
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