UCB's Bispecific Marks Phase 3 Win For Second Psoriatic Arthritis Study

UCB SA UCBJF posted topline results from the Phase 3 BE COMPLETE study evaluating Bimzelx (bimekizumab) for active psoriatic arthritis patients who were inadequate responders or intolerant to anti-tumor necrosis factor-alpha (anti-TNF-α) therapy.1 

• The study demonstrated that significantly more patients treated with bimekizumab achieved 50% or greater improvement in signs and symptoms of the disease compared with placebo.
• Bimekizumab showed significant improvements over placebo at week 16 in physical function, skin clearance, physical health status, and low disease activity.
• Based on these results, UCB plans to submit regulatory applications for bimekizumab in psoriatic arthritis in the U.S. and the European Union in Q3 of 2022.
• Related: UCB to Buy Epilepsy-Focused Zogenix In $1.9B Deal: See The Highlights.
• In the latest study, bimekizumab met the primary and secondary goals in non-radiographic axSpA in Phase 3 Be Mobile 1 study disclosed Tuesday. 
• Bimekizumab led to at least 40% improvement compared to baseline across measurements of disease activity, spinal pain, physical function, and inflammation at week 16. 
• The results add to the drug's achievement of primary and secondary goals in another phase 3 study called Be Mobile 2. 
• The drug also beat out placebo at other disease activity measurements, partial remission, and nighttime pain. 
• Price Action: UCBJY shares are up 0.06% at $51.43 during the market session on the last check Friday.