Tango Therapeutics' TNG908 IND For Cancer Study Gets Green Signal By FDA

The FDA has cleared Tango Therapeutics Inc's TNGX Investigational New Drug (IND) application for its lead program, TNG908.

• TNG908 is a synthetic lethal small molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) designed to kill cancer cells with a methylthioadenosine phosphorylase (MTAP) deletion. 
• MTAP deletions occur in 10% - 15% of all human cancers.
• Tango expects to initiate a Phase 1/2 trial in 1H of 2022, with preliminary safety and efficacy data expected in 1H of 2023.
• Enrollment will be limited to patients with confirmed MTAP-deleted tumors. 
• Related: Three Analysts Initiate Coverage On This Newly Listed Precision Oncology Firm.
• The Company is also working on Target 3, an undisclosed synthetic lethal target.
• In animal studies, Target 3 inhibition, combined with an anti-PD1 antibody, resulted in complete regressions and the induction of immune memory against re-implantation of tumors.
• Tango expects to advance a development candidate in the first half of 2022 and file an IND in 2023.
• The Company anticipates advancing a development candidate for their ubiquitin-specific protease 1 (USP1) program in 2H of 2022.
• Price Action: TNGX shares are down 5.96% at $7.81 during the market session on the last check Monday.