LAVA Therapeutics Shares Interim LAVA-051 Data From Early-Stage Cancer Trial

LAVA Therapeutics NV LVTX announced initial data from its first clinical study with LAVA-051.
The presentation will include data from the first three cohorts of the LAVA-051 Phase 1/2a trial, along with preclinical data on its two lead programs, LAVA-051 and LAVA-1207.
The first three dose-escalation cohorts showed LAVA-051 to be safe and well-tolerated with no dose-limiting toxicities or observed cytokine release syndrome.
Per the study protocol, the cohort three dose was 33-times that of the cohort one dose.
Drug exposure and Vγ9Vδ2, T cell receptor occupancy of LAVA-051, increased with LAVA-051 dose increases and peripheral blood Vγ9Vδ2 T cells also expressed higher levels of activation markers after LAVA-051 dosing.
One patient with chronic lymphocytic leukemia (CLL) experienced multiple enlarged tender diseased lymph nodes one week after first dosing that subsequently regressed, reminiscent of tumor flare.
Additional data from the dose-escalation phase of the trial is expected in Q2 of 2022 and from the disease-specific expansion cohorts in 2H of 2022.
In October last year, the FDA granted orphan drug designation to LAVA-051 to treat chronic lymphocytic leukemia (CLL).
The Phase 1/2a trial for LAVA-051 is initially being conducted in Europe. LAVA expects to file an Investigational New Drug (IND) application with the FDA, if accepted, will subsequently include patients in the U.S.
Price Action: LVTX shares are up 5.14% at $4.61 during the market session on the last check Monday.

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