INmune Bio's INKmune Shows Positive Efficacy In Multiple Cancer Cell Lines

  • INmune Bio Inc INMB has announced solid tumor data in multiple cancer lines resistant to NK killing that can be overcome with the administration of INKmune.
  • The Tumor Microenvironment (TME) interaction with cancer cells and immune cells can drive tumor progression and prevent many cell therapies from being effective. 
  • INKmune converts the patient's normal resting NK (rNK) cells into potent memory-like NK cells that target solid tumors directly, even in the presence of immunosuppressive immunoregulatory cells and hypoxia associated with the TME.
  • Related: INmune Bio Stock Jumps On Promising Biomarker Data From Early-Stage Blood Cancer Trial.
  • The company's preclinical data show that INKmune primes NK cells from patients and healthy donors to lyse NK-resistant ovarian (CaOva), prostate (CaPros), renal (RCC), and nasopharyngeal (NPC) cancer cells.
  • Compared to rNK cells, which are normal NK cells from healthy donors or patients before treatment with INKmune, the INKmune-primed NK cells demonstrated an enhanced ability to kill these resistant tumor cell lines.
  • The company identified more than 1,500 proteins that are upregulated in NK cells following INKmune priming and subsequent analysis compared them to NK cells primed with a cytokine cocktail of IL-12, IL-15 and IL-18. 
  • Price Action: INMB shares are up 5.43% at $7.30 on the last check Wednesday.
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