Regeneron Reveals An Early Cut Data From Follicular Lymphoma Study At ASH Meeting

Regeneron Pharmaceuticals Inc REGN gave the first look at interim results from its Phase 2 study of odronextamab, a CD20xCD3 bispecific antibody in patients with relapsed/refractory follicular lymphoma.
Trial investigators said 82% of 121 patients with the disease responded to Regeneron’s drug odronextamab, and 75% had a complete response.
Related: Regeneron Highlights Its First Phase 2 Data To Build Case In CD20xC3 Bispecific Space.
The median duration of complete response was 20.5 months, with a median progression-free survival of 20 months, according to a presentation at the annual American Society of Hematology conference.
In the new Phase 2 data, Regeneron said adverse events (AE) occurred in all patients, with 78% being ≥Grade 3.
Cytokine release syndrome (CRS) was recorded in 56.5% of patients. Discontinuations due to an AE occurred in 11.5% of patients, with three deaths.
There were no Grade 4 or 5 CRS cases, and the incidence of Grade 2 and Grade 3 was reduced with the modified step-up regimen compared to the original regimen.
Price Action: REGN shares closed lower by 1.01% at $742.48 on Monday.
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