Cellectis Touts Positive Preliminary Data From Two Leukemia Trials

Cellectis S.A CLLS highlighted updated clinical data on its Phase 1/2a BALLI-01 trial (evaluating UCART22) and on its Phase 1 AMELI-01 trial (evaluating UCART123).
Compared to the last clinical update on BALLI-01 at ASH 2021, the presented data comes from five additional patients who received UCART22 at dose level 3 (DL3) 5x106 cells/kg after lymphodepletion with FCA.
Evidence of UCART22 anti-tumor activity was observed in 60% (n=3) of the five patients.
A patient experienced a durable, minimal residual disease (MRD) negative complete response with incomplete count recovery (CRi) that continues beyond six months.
The company also shared preliminary data from patients who received UCART123.
The FCA LD regimen resulted in robust lymphodepletion for greater than 28 days in all patients. Seven out of nine patients demonstrated UCART123 expansion.
Two out of eight patients (25%) at DL2 with the FCA arm achieved a meaningful response.
A patient with stable disease achieved greater than 90% bone marrow blast reduction (60% to 5%) at Day 28.
Price Action: CLLS shares are up 8.52% at $2.42 on the last check Tuesday.
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