- Astria Therapeutics Inc ATXS announced preliminary results from the Phase 1a trial of STAR-0215 in healthy subjects.
- The company says that data establishes early proof of concept of STAR-0215 as a potential long-acting preventative treatment for hereditary angioedema (HAE).
- STAR-0215 was well-tolerated at all doses studied.
- The results showed rapid and sustained drug levels consistent with clinical benefit and sustained target engagement with plasma kallikrein inhibition for at least three months, supporting the potential for STAR-0215 to be dosed once every three months or less frequently.
- Astria plans to initiate the ALPHA-STAR Phase 1b/2 trial in HAE patients in Q1 2023.
- Initial results are expected from the single and multiple dose cohorts in mid-2024.
- Astria plans to evaluate the potential for 6-month dosing with additional healthy subject cohorts in the Phase 1a trial starting in Q1 2023, with initial results expected in Q4 2023.
- Concurrently, Astria priced an underwritten offering of 9.08 million shares at $11.01 per share for gross proceeds of $100 million.
- Price Action: ATXS shares are up 2.18% at $11.25 during the premarket session on the last check Thursday.
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