Neurocrine Biosciences, Voyager Therapeutics Collaborate For Neurological-Focused Gene Therapies

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  • Neurocrine Biosciences Inc NBIX and Voyager Therapeutics Inc VYGR have formed a new strategic collaboration to advance multiple gene therapies for neurological diseases. 
  • Voyager will receive up-front consideration of $175 million, including a $39 million equity investment, up to $1.5 billion in potential development milestones, additional potential commercial milestones, tiered royalties on net sales, program funding, and an option to elect 50/50 cost- and profit-sharing in the U.S. for the GBA1 program following Phase 1 readout.
  • The collaboration includes Voyager's preclinical GBA1 gene therapy program for Parkinson's disease and other GBA1-mediated diseases, which combines a GBA1 gene replacement payload with novel capsids from Voyager's TRACER platform. 
  • In addition, Neurocrine Biosciences and Voyager have also agreed to collaborate on three new gene therapy programs directed to rare CNS targets, each leveraging Voyager's novel TRACER capsids. 
  • Regarding the GBA1 gene therapy program, Neurocrine Biosciences has agreed to fund development through the completion of a first Phase 1 trial. 
  • Following the data readout, Voyager has the right, but not the obligation, to elect to co-develop and co-commercialize the GBA1 program with Neurocrine Biosciences in the U.S. under a 50/50 cost- and profit-sharing arrangement.
  • If Voyager declines its option for cost and profit sharing on the GBA1 program, it will be eligible for up to $985 million in total development milestone payments plus substantial potential commercial milestone payments and tiered royalties.
  • Price Action: VYGR shares are up 28.16% at $8.92 during the premarket session on the last check Monday.
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