Why Blueprint Medicines (BPMC) Shares Are Trading Lower Today - Blueprint Medicines (NASDAQ:BPMC)

The FDA has placed a partial clinical hold on Blueprint Medicines Corporation's BPMC Phase 1/2 VELA trial of BLU-222 due to visual adverse events (AEs) observed in a limited number of patients.
Patients currently enrolled in the trial continue on the study drug, and additional patients will not be enrolled until the partial clinical hold is resolved.
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The reported visual AEs consisted of transient, reversible episodes of light sensitivity and blurred vision.
All events were Grade 1, except one Grade 3 event involving light sensitivity and blurred vision in a patient treated at 600 mg BID.
All events were resolved with dose interruption or reduction.
No treatment-emergent abnormal findings, including uveitis, have been observed in patients who have received detailed ophthalmologic examinations.
Consistent with prior guidance, Blueprint Medicines plans to present initial dose escalation data from the VELA trial of BLU-222 in the first half of 2023.
"We have confidence in the benefit-risk profile of BLU-222 based on the activity and safety data we have seen to date in the dose escalation study," said Becker Hewes, Chief Medical Officer.
Price Action: BPMC shares are down 7.88% at $40.80 during the premarket session on the last check Friday.

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