- RenovoRx Inc RNXT announced interim data in the Phase 3 open-label TIGeR-PaC clinical trial investigating the company's first product candidate, RenovoGem, as a potential treatment option in locally advanced pancreatic cancer (LAPC).
- The interim analysis suggests a 6-month potential improvement in median overall survival with RenovoGem.
- The study compares treatment with RenovoTAMP versus standard-of-care systemic intravenous administration of gemcitabine and nab-paclitaxel, which has a seven-week survival benefit and a $1 billion addressable market.
- Related: RenovoRx Reports Initial Results From Targeted Treatment For Pancreatic Cancer.
- This first-of-two interim analysis indicates that the TIGeR-PaC study is on track to demonstrate increased lifespan for patients treated with RenovoGem for LAPC.
- In this interim analysis, the control and treatment arms demonstrated divergence in median overall survival for patients.
- Twenty-three patients were randomized to the intra-arterial gemcitabine (RenovoGem investigational treatment) arm and 22 to the continuation of IV gemcitabine and nab-paclitaxel (control or standard of care) arm.
- There were an equal number of primary events, 13 in each arm.
- The median overall survival in the IV gemcitabine and nab-paclitaxel control arm was ten months versus 16 months in the intra-arterial RenovoGem arm.
- Observed a positive trend in median overall survival by 24 weeks. In this interim analysis, the statistical significance was not reached to stop the study early.
- Price Action: RNXT shares are up 0.33% at $4.92 on the last check Wednesday.
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