- Connect Biopharma Holdings Limited CNTB announced post hoc data analysis from the Phase 2b CBP-201 global trial in moderate-to-severe atopic dermatitis (AD).
- The data exhibited that CBP-201 led to rapid and sustained improvement in AD signs and symptoms across all four body regions, compared to the placebo.
- EASI subscores improved in all four body regions across 16 weeks of treatment.
- Improvements between 300 mg Q2W and Q4W were comparable. At Week 2, EASI decreased by -26.3% (head/neck), -26.4% (trunk), -21.6% (upper limbs), and -23.2% (lower limbs) for patients on CBP-201 300 mg Q4W treatment vs. -9.5% to -15.7% with placebo.
- At Week 16, EASI decreased further to -69.2% (head and neck), -72.1% (trunk), -64.2% (upper limbs), and -68.5% (lower limbs) vs. -21.2% to -49.1% with placebo (p<0.01 per region).
- Researchers also observed improvement for each classification of AD symptoms (signs): erythema, induration/papulation, lichenification, and excoriation, within each body region.
- Concurrently, the company also announced data from Stage 1 of the ongoing pivotal CBP-201 China trial in moderate-to-severe atopic dermatitis (AD), exhibiting rapid relief from symptoms.
- The study met primary and secondary endpoints, with mostly mild-to-moderate adverse effects reported.
- At 16 weeks, more patients treated with CBP-201 achieved an IGA score of 0-1 (clear or almost clear skin) and a 2-point IGA reduction than those on placebo (30.3% vs. 7.5%).
- 62.9% of CBP-201 patients achieved a 75% skin clearance (EASI-75), versus 23.4% in the placebo group and EASI-90 of (35.8% vs. 63.%).
- Price Action: CNTB shares are up 20.90% at $1.33 during the premarket session on the last check Monday.
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