Ozempic Alternatives: These Two Drugs Show Promise In Affordability And Effectiveness For Weight Loss

Two new drugs, Orforglipron and Retatrutide, are set to redefine the obesity treatment landscape with their potential affordability and unprecedented efficacy, Scientific American reports.

Potential Game Changers: Orforglipron, one of the two drugs, is anticipated to be easier to use, produce, and likely cheaper than existing treatments.

Internal-medicine physician Sean Wharton at McMaster University, who co-authored the orforglipron study, says “I see it as a game changer, myself.”

The second drug, Retatrutide offers an unprecedented level of efficacy and can potentially raise the bar for treating obesity. Participants lost an average of 24.2% of their body weight over 11 months of treatment when the highest dose was used in the trial. Comparatively, currently approved drugs result about 15–20% weight loss over a similar time frame.

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The Future of Obesity Treatment: While these drugs represent a significant step forward, experts caution that they are not a cure-all.

“The idea that you could stop the medication and not have the weight regain is a non-biological idea, which doesn't make any sense,” says Wharton.

However, the medicines can be a solution for those seeking relief from obesity.

"Medications are not and will not be the only solution, but they are one revolutionary step forward in countering the epidemic," says obesity-medicine specialist Beverly Tchang at Weill Cornell Medicine in New York City.

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