Curis Announces Dosing of First Patient in Phase I CUDC-101 Head and Neck Cancer Combination Trial

Curis, Inc. CRIS today announced that the first patient has been treated in a Phase I combination trial of CUDC-101. The Phase I trial is the Company's first CUDC-101 combination study and is designed to test CUDC-101 when administered concurrently with radiation and cisplatin in human papillomavirus negative (HPV-) locally advanced head and neck cancer patients. CUDC-101 is a first-in-class small molecule drug candidate that has been designed as an inhibitor of epidermal growth factor receptor, human epidermal growth factor receptor 2 (Her2) and histone deacetylase (HDAC). The first patient was treated at the University of Colorado Cancer Center under the care of Antonio Jimeno, M.D., Ph.D. “We are excited to participate in this trial, which primarily aims to establish the optimal combination dose of CUDC-101 when combined with current standard of care radiation and cisplatin as well as to build on Curis' previous clinical observations in which signs of biological activity were observed with single-agent CUDC-101 in advanced head and neck cancer patients," commented Dr. Jimeno. "We believe that CUDC-101 is a potentially promising drug candidate in the head and neck cancer setting and we look forward to exploring the potential of CUDC-101 in combination with radiation and cisplatin in this study.”