Tetraphase Pharmaceuticals Inc TTPH shares dipped 78.70 percent to $9.54 after failing to meet the primary endpoint of statistical non-inferiority for IGNITE2, compared to levofloxacin.
Flexion Therapeutics Inc FLXN dropped 30.28 percent to $20.22 after failing to demonstrate statistical significance for the primary endpoint for FX006.
Aquinox Pharmaceuticals Inc AQXP shares fell 8.92 percent to $14.30 after the company reported a proposed public offering of $75 million of common stock.
MannKind Corporation MNKD shares declined 8.85 percent to $3.71. Piper Jaffray downgraded MannKind from Neutral to Underweight and lowered the price target from $4 to $1.50.
Kulicke and Soffa Industries Inc. KLIC shares fell 7.18 percent to $9.92 after the company lowered its Q4 revenue forecast.
Barnes & Noble, Inc. BKS shares dropped 6.63 percent to $15.22. Barnes & Noble posted a quarterly net loss of $0.68 per share, versus a year-ago loss of $0.56 per. Its revenue declined 1.5 percent to $1.22 billion.
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