18 Biggest Mid-Day Losers For Wednesday

Arrowhead Pharmaceuticals Inc ARWR shares tumbled 65.2 percent to $1.53 after the company announced it was discontinuing all its clinical RNAi programs. The company also announced plans to reduce workforce by 30 percent.
Cerecor Inc CERC shares tumbled 55 percent to $2.12 after the company reports top-line data from CERC-301. The trial failed to demonstrate efficacy on the primary endpoint.
Dataram Corp DRAM shares fell 17 percent to $1.17. Dataram shares have dropped 53.92 percent over the past 52 weeks, while the S&P 500 index has gained 5.97 percent in the same period.
Acasti Pharma Inc ACST shares declined 16.5 percent to $1.50.
Costamare Inc CMRE shares dropped 14.4 percent to $5.70 as the company announced a public offering of 11 million common stock.
American Eagle Outfitters AEO shares dipped 14 percent to $16.28. American Eagle posted in-line Q3 earnings. However, the company posted weak quarterly comparable sales and issued a weak outlook for the current quarter.
Nivalis Therapeutics Inc NVLS fell 13.6 percent to $2.22. Nivalis Therapeutics shares have tumbled 69.04 percent over the past 52 weeks, while the S&P 500 index has gained 5.97 percent in the same period.
Cogint, Inc. COGT declined 11.1 percent to $3.20. Cogint named Greg Johnson as Chief Revenue Officer.
Fifth Street Finance Corp. FSC fell 10.3 percent to $5.29. Fifth Street Finance reported a FQ4 loss of $3.4 million on revenue of $59.2 million. The company named Patrick J. Dalton as Chief Executive Officer.
PAVmed Inc. PAVM shares dropped 8.1 percent to $8.00.
First Bancorp FBP shares fell 6.8 percent to $5.93 after the company reported that THL and Oaktree have commenced secondary offering of 18 million shares.
Farmland Partners Inc FPI slipped 6.3 percent to $11.09 after the company reported an offering of 3.1 million shares of common stock.
Autodesk, Inc. ADSK shares declined 4.4 percent to $71.97. Autodesk reported upbeat results for its third quarter, but issued a weak outlook for the fourth quarter.
Mantech International Corp MANT dropped 3.6 percent to $43.24. Maxim Group downgraded Mantech from Buy to Hold.
Nutanix Inc NTNX shares fell 3.3 percent to $32.98. Nutanix reported a narrower-than-expected loss for its first quarter and issued a strong forecast for the current quarter.
W. R. Grace & Co GRA declined 3.1 percent to $64.96. Jefferies downgraded W. R. Grace from Buy to Hold.
Tuniu Corp TOUR fell 2.8 percent to $8.95. uniu reported a Q3 loss of $85.2 million on revenue of $607 million.
HB Fuller Co FUL dropped 2.4 percent to $47.35. JP Morgan downgraded HB Fuller from Overweight to Neutral.