Gainers

  • Proteostasis Therapeutics Inc PTI shares climbed 54.11 percent to close at $6.38 on Tuesday after the biopharmaceutical company that focuses on treating diseases caused by an imbalance in the proteostasis network announced an update. The company said the FDA granted a Breakthrough Therapy Designation for its PTI-428, a cystic fibrosis transmembrane conductance regulator (CFTR) amplifier.
  • Endocyte, Inc. ECYT gained 22.54 percent to close at $10.82.
  • BlueLinx Holdings Inc. BXC shares rose 21.51 percent to close at $34.06. BlueLinx shares gained 77.52 percent Monday after the company reported a $413 million merger with Cedar Creek.
  • Bovie Medical Corporation BVX gained 21.12 percent to close at $2.81 following a fourth quarter earnings and sales beat.
  • Orgenesis Inc. ORGS rose 20.82 percent to close at $11.1758.
  • Athersys, Inc. ATHX gained 17.95 percent to close at $1.84 after biotechnology company that focuses on regenerative medicine received an equity investment. The company said it received a $21 million equity investment at $1.76 per share from Healios K.K. as part of a plan to significantly expanding their existing development and commercialization collaboration.
  • Atomera Incorporated ATOM shares jumped 17.17 percent to close at $7.03 on Tuesday.
  • Allena Pharmaceuticals, Inc. ALNA gained 14.46 percent to close at $7.60.
  • American Vanguard Corp. AVD rose 14.32 percent to close at $23.15 as the company posted upbeat quarterly results.
  • Myovant Sciences Ltd. MYOV shares climbed 13.65 percent to close at $19.23.
  • Vaxart, Inc. VXRT rose 13.58 percent to close at $6.94 on Tuesday.
  • Northstar Realty Europe Corp NRE gained 12.09 percent to close at $12.42 following Q4 results.
  • Xplore Technologies Corp. XPLR rose 11.45 percent to close at $3.70 on Tuesday.
  • DSW Inc. DSW shares gained 10.71 percent to close at $21.70. DSW reported stronger-than-expected earnings for its fourth quarter, while sales missed estimates.
  • Purple Innovation, Inc. PRPL climbed 10.56 percent to close at $12.15.
  • BRT Apartments Corp. BRT shares gained 9.92 percent to close at $11.41 on Tuesday. BRT Apartments raised its quarterly dividend by around 11.1 percent.
  • Sify Technologies Limited SIFY shares climbed 9.5 percent to close at $2.19.
  • Zosano Pharma Corp ZSAN gained 8.5 percent to close at $16.70. Zosana Pharma reported a Q4 loss of $3.80 per share on Monday.
  • MediciNova, Inc. MNOV rose 6.02 percent to close at $13.91.
  • Cutera, Inc. CUTR rose 5.34 percent to close at $53.30. Stephens & Co. initiated coverage on Cutera with an Overweight rating.
  • M.D.C. Holdings, Inc. MDC gained 4.98 percent to close at $29.70. UBS upgraded M.D.C. from Sell to Buy.
  • HD Supply Holdings Inc HDS rose 3.31 percent to close at $38.09 as the company reported better-than-expected earnings for its fourth quarter an issued a strong forecast for FY18.

Check out these big penny stock gainers and losers

Losers

  • Silicom Ltd. SILC shares tumbled 30.57 percent to close at $40.66 on Tuesday.
  • CGG SA (ADR) CGG shares declined 24.56 percent to close at $2.15 on Tuesday after dropping 31.33 percent on Monday.
  • iFresh Inc. IFMK dropped 24.41 percent to close at $6.69.
  • CounterPath, Corp. CPAH fell 22.89 percent to close at $3.57 after the company reported results for its third quarter.
  • Commercial Vehicle Group, Inc. CVGI shares tumbled 19.96 percent to close at $8.90 after the company posted downbeat results for its fourth quarter.
  • Marathon Patent Group Inc MARA declined 18.93 percent to close at $1.97.
  • Tilly's Inc TLYS fell 17.5 percent to close at $11.83 after the company reported weaker-than-expected results for its fourth quarter. The company also issued weak first quarter guidance.
  • Fanhua Inc (ADR) FANH fell 16.04 percent to close at $27.21. Fanhua reported Q4 earnings of $0.30 per share on sales of $106.12 million.
  • RXi Pharmaceuticals Corporation RXII shares tumbled 14.89 percent to close at $3.20.
  • Aralez Pharmaceuticals Inc ARLZ shares dipped 13.86 percent to close at $1.74. Aralez reported a Q4 loss of $0.68 per share on sales of $28 million.
  • Phoenix New Media Ltd ADR FENG fell 12.24 percent to close at $5.02 following Q4 results.
  • Myriad Genetics, Inc. MYGN fell 12.14 percent to close at $29.01.
  • Advaxis, Inc. ADXS fell 11.76 percent to close at $1.95. Advaxis reported a Q1 loss of $0.49 per share and announced a clinical hold in axalimogene filolisbac Phase 1/2 combination study with AstraZeneca's IMFINZI.
  • Pacific Ethanol, Inc. PEIX shares dropped 11.44 percent to close at $3.675.
  • Daxor Corporation DXR shares fell 11.35 percent to close at $5.00 on Tuesday.
  • China Customer Relations Centers, Inc. CCRC shares dipped 11.21 percent to close at $13.55.
  • Madrigal Pharmaceuticals Inc MDGL fell 10.89 percent to close at $127.345. Madrigal Pharma reported a Q4 loss of $0.67 per share.
  • Net Element, Inc. NETE shares dropped 10.52 percent to close at $12.08.
  • Atara Biotherapeutics, Inc. ATRA shares fell 10.42 percent to close at $41.25 on Tuesday.
  • Innovate Biopharmaceuticals Inc INNT declined 9.69 percent to close at $17.00. Innovate Biopharmaceuticals named Dr. June Almenoff as COO and Chief Medical Officer.
  • Vocera Communications Inc VCRA shares fell 9.09 percent to close at $24.79. Leerink Swann downgraded Vocera Communications from Outperform to Market Perform.
  • Helios and Matheson Analytics Inc HMNY shares fell 9.07 percent to close at $4.01.
  • QUALCOMM, Inc. QCOM shares fell 4.95 percent to close at $59.70 in reaction to U.S. President Donald Trump's move to block Broadcom Ltd AVGO's proposed takeover of the U.S.-based digital communication technology company. Trump cited "credible evidence" the takeover led by the Singapore-based company "threatens to impair the national security of the US."
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