Before 10 a.m. ET on Wednesday, 6 companies hit new 52-week lows.

Noteables:

• The largest company by market cap to set a new 52-week low was Splunk SPLK.
• Altisource Portfolio ASPS was the smallest firm by market cap to set a new 52-week low.
• Mesoblast MESO's stock came under the most pressure, trading down 2.16% to reach a new 52-week low.

During the first half-hour of trading on Wednesday, the following stocks set new 52-week lows:

• Splunk SPLK shares set a new 52-week low of $125.70. The stock traded down 0.09%.
• iRhythm Technologies IRTC shares were down 1.75% for the day, having made a 52-week low of $77.28.
• Mesoblast MESO shares reached a new 52-week low of $7.24 on Wednesday morning, moving down 2.16%.
• First Capital FCAP stock hit a yearly low of $44.65. The stock was down 0.18% for the day.
• Protara Therapeutics TARA shares reached a new 52-week low of $11.38 on Wednesday morning, moving down 1.61%.
• Altisource Portfolio ASPS stock broke to a new 52-week low of $6.24 on Wednesday. Shares of the company traded down 1.42%.

Stay with Benzinga for further updates about these companies and many others going forward.