Before 10 a.m. ET on Tuesday, 48 companies set new 52-week lows.

Interesting Highlights:

• Marqeta MQ was the largest company by market cap to set a new 52-week low.
• Avenue Therapeutics ATXI was the smallest firm by market cap to set a new 52-week low.
• Simulations Plus SLP shares dropped the most, trading down 14.96% to reach its new 52-week low.

During the first half-hour of trading on Tuesday, the following stocks set new 52-week lows:

• Marqeta MQ shares hit a yearly low of $23.83. The stock was down 5.58% on the session.
• SoFi Technologies SOFI stock achieved a new 52-week low on Tuesday morning, hitting $16.05 and moving down 1.83%.
• Erie Indemnity ERIE shares set a new yearly low of $184.23 this morning. The stock was down 1.26% on the session.
• QuantumScape QS stock hit a yearly low of $23.50. The stock was down 2.87% for the day.
• Allogene Therapeutics ALLO shares hit a yearly low of $22.95. The stock was down 2.56% on the session.
• Cannae Holdings CNNE shares fell to $32.44 on Tuesday, setting a new 52-week low with a shift of down 0.85%.
• Desktop Metal DM stock drifted down 3.19% on Tuesday morning to hit a new 52-week low of $9.67.
• Custom Truck One Source CTOS stock hit a yearly low of $8.40. The stock was down 5.82% for the day.
• iRhythm Technologies IRTC shares set a new 52-week low of $57.66. The stock traded down 2.8%.
• Singular Genomics Systems OMIC stock hit a yearly low of $22.51. The stock was down 5.54% for the day.
• Sapiens Intl Corp SPNS stock hit $25.22 on Tuesday morning, setting a new 52-week low for a change of down 2.24%.
• Honest Co HNST stock drifted down 2.01% on Tuesday morning to hit a new 52-week low of $13.90.
• uniQure QURE stock set a new 52-week low of $27.25 on Tuesday, moving down 2.34%.
• Zeta Global Holdings ZETA stock drifted down 2.85% on Tuesday morning to hit a new 52-week low of $6.41.
• Cloopen Group Holding RAAS stock drifted down 1.42% on Tuesday morning to hit a new 52-week low of $6.17.
• Simulations Plus SLP stock hit a yearly low of $44.55. The stock was down 14.96% for the day.
• Mersana Therapeutics MRSN stock broke to a new 52-week low of $12.28 on Tuesday. Shares of the company traded down 3.57%.
• Vital Farms VITL stock set a new 52-week low of $18.76 on Tuesday, moving down 1.46%.
• Home Point Capital HMPT stock drifted down 2.98% on Tuesday morning to hit a new 52-week low of $5.16.
• Vor Biopharma VOR stock dropped to a yearly low on Tuesday of $17.07. Shares traded down 5.52%.
• Enthusiast Gaming EGLX stock achieved a new 52-week low on Tuesday morning, hitting $4.80 and moving down 6.25%.
• SOC Telemed TLMD stock broke to a new 52-week low of $4.64 on Tuesday. Shares of the company traded down 1.69%.
• Codex DNA DNAY stock broke to a new 52-week low of $15.15 on Tuesday. Shares of the company traded down 4.65%.
• Orchard Therapeutics ORTX stock hit a yearly low of $3.63. The stock was down 3.16% for the day.
• Finance of America FOA shares set a new yearly low of $6.91 this morning. The stock was down 2.25% on the session.
• Molecular Templates MTEM stock drifted down 2.16% on Tuesday morning to hit a new 52-week low of $7.14.
• Black Diamond Therapeutic BDTX stock achieved a new 52-week low on Tuesday morning, hitting $10.71 and moving down 3.14%.
• CytomX Therapeutics CTMX shares set a new yearly low of $5.81 this morning. The stock was down 3.14% on the session.
• Cue Biopharma CUE shares set a new 52-week low of $10.52. The stock traded down 3.35%.
• Durect DRRX stock broke to a new 52-week low of $1.40 on Tuesday. Shares of the company traded down 0.35%.
• BIT Mining BTCM stock hit $5.17 on Tuesday morning, setting a new 52-week low for a change of down 3.92%.
• Kala Pharmaceuticals KALA stock hit a yearly low of $4.26. The stock was down 3.68% for the day.
• Aptose Biosciences APTO stock dropped to a yearly low on Tuesday of $3.09. Shares traded down 2.21%.
• Sandbridge Acquisition SBG stock dropped to a yearly low on Tuesday of $9.51. Shares traded down 2.16%.
• Terns Pharmaceuticals TERN stock set a new 52-week low of $9.79 on Tuesday, moving down 1.69%.
• Sensei Biotherapeutics SNSE shares set a new 52-week low of $7.80. The stock traded down 3.2%.
• Sigilon Therapeutics SGTX stock hit a new 52-week low of $6.15. The stock was down 4.41% on the session.
• GX Acquisition GXGX shares made a new 52-week low of $9.92 on Tuesday. The stock was down 2.02% for the day.
• OneSmart Intl Edu Group ONE shares set a new yearly low of $0.99 this morning. The stock was down 0.98% on the session.
• PolyPid PYPD shares hit a yearly low of $8.16. The stock was down 3.54% on the session.
• Vista Gold VGZ stock hit $0.79 on Tuesday morning, setting a new 52-week low for a change of up 0.82%.
• Jiuzi Holdings JZXN shares fell to $4.54 on Tuesday, setting a new 52-week low with a shift of down 2.12%.
• Minerva Neurosciences NERV shares set a new 52-week low of $2.08. The stock traded down 4.52%.
• Leap Therapeutics LPTX stock achieved a new 52-week low on Tuesday morning, hitting $1.41 and moving down 4.61%.
• Aziyo Biologics AZYO shares set a new yearly low of $7.47 this morning. The stock was down 2.99% on the session.
• Universe Pharmaceuticals UPC stock hit a yearly low of $2.82. The stock was down 1.37% for the day.
• MEDIROM Healthcare MRM shares set a new yearly low of $8.03 this morning. The stock was up 3.62% on the session.
• Avenue Therapeutics ATXI shares reached a new 52-week low of $2.20 on Tuesday morning, moving down 3.92%.

Benzinga will continue to update investors on 52-week lows hit in these and other stocks. Stay tuned!