On Wednesday morning, 67 companies achieved new lows for the year.

Areas of Significance:

• Grifols GRFS was the largest firm by market cap to set a new 52-week low.
• GreenVision Acquisition GRNV was the smallest company in terms of market cap to set a new 52-week low.
• AppHarvest APPH's stock dropped the most, trading down 33.67% to reach a new 52-week low.

During the first half-hour of trading on Wednesday, the following stocks set new 52-week lows:

• Grifols GRFS stock drifted up 0.54% on Wednesday morning to hit a new 52-week low of $14.66.
• Neurocrine Biosciences NBIX shares set a new yearly low of $85.82 this morning. The stock was down 1.18% on the session.
• TuSimple Hldgs TSP stock achieved a new 52-week low on Wednesday morning, hitting $30.81 and moving down 3.09%.
• Amedisys AMED shares hit a yearly low of $190.26. The stock was down 1.55% on the session.
• Pan American Silver PAAS stock set a new 52-week low of $24.95 on Wednesday, moving up 3.29%.
• Skillz SKLZ shares moved down 0.95% on Wednesday to hit a new 52-week low of $11.84, drifting down 0.95%.
• Q2 Holdings QTWO stock set a new 52-week low of $82.80 on Wednesday, moving down 1.02%.
• 1Life Healthcare ONEM stock set a new 52-week low of $24.19 on Wednesday, moving down 1.86%.
• Arena Pharmaceuticals ARNA stock dropped to a yearly low on Wednesday of $50.91. Shares traded down 0.71%.
• Oscar Health OSCR shares moved down 2.68% on Wednesday to hit a new 52-week low of $14.55, drifting down 2.68%.
• Nektar Therapeutics NKTR stock drifted down 0.97% on Wednesday morning to hit a new 52-week low of $14.62.
• GoHealth GOCO shares hit a yearly low of $8.37. The stock was down 1.86% on the session.
• Grocery Outlet Holding GO shares were down 12.42% for the day, having made a 52-week low of $26.92.
• Poshmark POSH shares hit a yearly low of $28.50. The stock was down 9.5% on the session.
• InnovAge Holding INNV stock hit $15.69 on Wednesday morning, setting a new 52-week low for a change of down 1.76%.
• Nuvation Bio NUVB shares were down 1.87% for the day, having made a 52-week low of $8.04.
• Root ROOT stock hit $6.79 on Wednesday morning, setting a new 52-week low for a change of up 0.73%.
• Outset Medical OM stock drifted down 1.71% on Wednesday morning to hit a new 52-week low of $36.03.
• Hims & Hers Health HIMS shares set a new yearly low of $7.31 this morning. The stock was down 4.97% on the session.
• eHealth EHTH shares set a new 52-week low of $47.26. The stock traded down 1.62%.
• Singular Genomics Systems OMIC shares were down 0.82% for the day, having made a 52-week low of $15.01.
• Kura Oncology KURA shares made a new 52-week low of $16.66 on Wednesday. The stock was down 0.94% for the day.
• ON24 ONTF shares were down 28.49% for the day, having made a 52-week low of $21.50.
• Lordstown Motors RIDE stock hit $5.65 on Wednesday morning, setting a new 52-week low for a change of down 2.38%.
• New Gold NGD shares fell to $1.36 on Wednesday, setting a new 52-week low with a shift of down 0.35%.
• Nautilus Biotechnology NAUT shares set a new yearly low of $7.20 this morning. The stock was down 2.51% on the session.
• Kiniksa Pharmaceuticals KNSA shares set a new 52-week low of $12.32. The stock traded down 1.11%.
• AppHarvest APPH shares moved down 33.67% on Wednesday to hit a new 52-week low of $7.52, drifting down 33.67%.
• Zogenix ZGNX shares made a new 52-week low of $13.81 on Wednesday. The stock was down 1.06% for the day.
• Talkspace TALK stock set a new 52-week low of $4.60 on Wednesday, moving down 3.82%.
• CareMax CMAX stock set a new 52-week low of $8.15 on Wednesday, moving up 2.75%.
• Akero Therapeutics AKRO shares moved down 1.04% on Wednesday to hit a new 52-week low of $19.11, drifting down 1.04%.
• EverQuote EVER stock set a new 52-week low of $22.05 on Wednesday, moving down 1.37%.
• Trillium Therapeutics TRIL stock hit $6.12 on Wednesday morning, setting a new 52-week low for a change of down 3.13%.
• Home Point Capital HMPT stock achieved a new 52-week low on Wednesday morning, hitting $4.51 and moving down 0.44%.
• Seres Therapeutics MCRB stock hit a new 52-week low of $6.60. The stock was down 1.04% on the session.
• Epizyme EPZM shares set a new 52-week low of $5.46. The stock traded up 0.73%.
• Vasta Platform VSTA shares made a new 52-week low of $6.25 on Wednesday. The stock was down 2.34% for the day.
• Cementos Pacasmayo CPAC stock achieved a new 52-week low on Wednesday morning, hitting $5.54 and moving down 1.26%.
• iClick Interactive Asia ICLK stock hit a new 52-week low of $4.77. The stock was down 1.64% on the session.
• TherapeuticsMD TXMD stock achieved a new 52-week low on Wednesday morning, hitting $0.90 and moving down 0.4%.
• Relmada Therapeutics RLMD shares set a new yearly low of $20.60 this morning. The stock was down 8.04% on the session.
• VectoIQ Acquisition Corp VTIQ shares moved up 0.31% on Wednesday to hit a new 52-week low of $9.61, drifting up 0.31%.
• CytomX Therapeutics CTMX shares set a new 52-week low of $4.83. The stock traded up 1.83%.
• Harpoon Therapeutics HARP stock hit $9.00 on Wednesday morning, setting a new 52-week low for a change of down 2.45%.
• Avrobio AVRO shares set a new 52-week low of $5.85. The stock traded down 0.3%.
• Eros STX Global ESGC shares were down 4.86% for the day, having made a 52-week low of $0.63.
• Kamada KMDA shares set a new 52-week low of $5.28. The stock traded down 5.34%.
• Adicet Bio ACET shares set a new yearly low of $6.81 this morning. The stock was down 1.51% on the session.
• Biodesix BDSX stock hit a new 52-week low of $7.85. The stock was down 17.38% on the session.
• Talis Biomedical TLIS stock broke to a new 52-week low of $7.52 on Wednesday. Shares of the company traded down 8.7%.
• TFF Pharmaceuticals TFFP shares moved down 2.45% on Wednesday to hit a new 52-week low of $7.38, drifting down 2.45%.
• E-Home Household Service EJH shares set a new 52-week low of $4.55. The stock traded down 6.35%.
• Americas Gold And Silver USAS stock hit $1.22 on Wednesday morning, setting a new 52-week low for a change of down 1.6%.
• Huize Holding HUIZ stock hit a yearly low of $3.07. The stock was down 2.34% for the day.
• Spok Holdings SPOK shares set a new yearly low of $7.51 this morning. The stock was down 0.79% on the session.
• Sio Gene Therapies SIOX shares hit a yearly low of $1.92. The stock was up 0.25% on the session.
• OptiNose OPTN stock hit $2.50 on Wednesday morning, setting a new 52-week low for a change of down 2.26%.
• Pop Culture Gr CPOP stock broke to a new 52-week low of $4.70 on Wednesday. Shares of the company traded down 0.41%.
• Viridian Therapeutics VRDN shares moved down 2.86% on Wednesday to hit a new 52-week low of $12.89, drifting down 2.86%.
• Eton Pharmaceuticals ETON stock dropped to a yearly low on Wednesday of $4.38. Shares traded down 0.44%.
• Fury Gold Mines FURY stock drifted down 0.12% on Wednesday morning to hit a new 52-week low of $0.87.
• Otonomy OTIC shares made a new 52-week low of $1.54 on Wednesday. The stock was down 0.42% for the day.
• Baudax Bio BXRX stock achieved a new 52-week low on Wednesday morning, hitting $0.53 and moving down 3.09%.
• Happiness Biotech Gr HAPP shares set a new 52-week low of $1.19. The stock traded down 1.72%.
• MEDIROM Healthcare MRM shares hit a yearly low of $6.70. The stock was down 1.9% on the session.
• GreenVision Acquisition GRNV shares were down 5.04% for the day, having made a 52-week low of $8.29.

Benzinga will continue to update investors on these equities. Stay tuned for further news.