U.S. stocks traded higher, with the Dow Jones gaining over 100 points on Wednesday. Here are some big stocks recording gains in today’s session.

  • Avidity Biosciences, Inc. RNA shares jumped 44.3% to $15.84 after the company announced AOC 1001 data from the preliminary assessment of the Phase 1/2 MARINA trial demonstrating the first-ever successful targeted delivery of RNA into muscle.
  • Wave Life Sciences Ltd. WVE surged 21.1% to $5.80. SVB Leerink maintained WAVE Life Sciences with a Market Perform and raised the price target from $2 to $7.
  • Kymera Therapeutics, Inc. KYMR shares rose 21.4% to $31.38 after the company announced results from the Phase 1 clinical trial evaluating KT-474 in patients with HS and AD and Sanofi's decision to advance KT-474 into Phase 2 clinical trials.
  • REV Group, Inc. REVG rose 17.2% to $15.57 as the company reported a fourth-quarter FY22 sales growth of 5.7% year-over-year to $623.6 million, beating the consensus of $595 million.
  • Dyne Therapeutics, Inc. DYN gained 16.4% to $14.19.
  • Harmonic Inc. HLIT gained 12.9% to $14.86
  • Carvana Co. CVNA gained 12.8% to $5.45.
  • Harrow Health, Inc. HROW surged 11.9% to $12.43. Harrow Health entered a binding agreement to acquire the exclusive U.S. commercial rights to five FDA‑approved ophthalmic products from Novartis.
  • Bloom Energy Corporation BE gained 10.3% to $24.26. UBS initiated coverage on Bloom Energy with a Buy rating and announced a price target of $35.
  • Mullen Automotive, Inc. MULN jumped 10% to $0.2354. Mullen Automotive partnered with Loop Global to deploy EV charging solutions, including public DC fast charging network and residential offerings.
  • Oppenheimer Holdings Inc. OPY gained 9.7% to $44.19. Oppenheimer Holdings announced share repurchase program; authorizes the company to purchase up to 543,000 shares of the company's Class A non-voting common stock.
  • SoFi Technologies, Inc. SOFI rose 9.7% to $4.86. SoFi Technologies CEO Anthony Noto reported purchase of 1,134,065 shares at ab average price of $4.42 per share.
  • Mondee Holdings, Inc. MOND gained 8.8% to $9.50.
  • Plug Power Inc. PLUG rose 8.3% to $15.29. UBS initiated coverage on Plug Power with a Buy rating and announced a price target of $26.
  • Cytokinetics, Incorporated CYTK jumped 7.6% to $41.27. The FDA's Cardiovascular and Renal Drugs Advisory Committee voted 8-3 against the approval of Cytokinetics heart failure drug, omecamtiv mecarbil.

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