Gainers
- Crown ElectroKinetics Corp. CRKN shares rose 153% to $0.3325 after gaining 14% on Tuesday. Crown ElectroKinetics, last month, posted a Q3 loss of $0.18 per share.
- Vallon Pharmaceuticals, Inc. VLON shares jumped 140% to $0.6041 after the company entered into a definitive merger agreement with GRI Bio.
- Immix Biopharma, Inc. IMMX jumped 46% to $2.1695 after the company announced it has in-licensed BCMA-targeted next-generation CAR-T therapy NXC-201 with 85% ORR and 71% CR/sCR at the therapeutic dose from the first 20 patients in an ongoing phase 1b relapsed/refractory multiple myeloma ongoing clinical trial.
- Senti Biosciences, Inc. SNTI rose 45% to $2.09 after dipping more than 21% on Tuesday.
- Avidity Biosciences, Inc. RNA shares climbed 44.3% to $15.84 after the company announced AOC 1001 data from the preliminary assessment of the Phase 1/2 MARINA trial demonstrating the first-ever successful targeted delivery of RNA into muscle.
- BIMI International Medical, Inc. BIMI gained 28.1% to $2.6649. BIMI reported entry into a material definitive agreement for the acquisition of Wuzhou Qiangsheng Hospital Co., Ltd., Suzhou Eurasia Hospital Co., Ltd. and Yunan Yuxi Minkang Hospital Co., Ltd.
- Wave Life Sciences Ltd. WVE gained 21.1% to $5.80. SVB Leerink maintained WAVE Life Sciences with a Market Perform and raised the price target from $2 to $7.
- Kymera Therapeutics, Inc. KYMR shares gained 21.4% to $31.38 after the company announced results from the Phase 1 clinical trial evaluating KT-474 in patients with HS and AD and Sanofi's decision to advance KT-474 into Phase 2 clinical trials.
- Aspen Group, Inc. ASPU gained 17.4% to $0.41 after reporting strong quarterly sales.
- REV Group, Inc. REVG jumped 17.2% to $15.57 as the company reported a fourth-quarter FY22 sales growth of 5.7% year-over-year to $623.6 million, beating the consensus of $595 million.
- Nuvve Holding Corp. NVVE gained 16.9% to $0.7477.
- Meiwu Technology Company Limited WNW jumped 16.3% to $2.14.
- United Insurance Holdings Corp. UIHC jumped 16.2% to $0.5578.
- Dyne Therapeutics, Inc. DYN jumped 14.7% to $14.00.
- Sio Gene Therapies Inc. SIOX gained 14.7% to $0.3537.
- Otonomy, Inc. OTIC jumped 14.4% to $0.1399.
- Harmonic Inc. HLIT gained 12.9% to $14.86
- Happiness Development Group Limited HAPP rose 12.9% to $3.9973after surging over 10% on Tuesday.
- Carvana Co. CVNA gained 12.8% to $5.45.
- Appreciate Holdings, Inc. SFR jumped 12.4% to $1.90.
- Harrow Health, Inc. HROW surged 11.9% to $12.43. Harrow Health entered a binding agreement to acquire the exclusive U.S. commercial rights to five FDA‑approved ophthalmic products from Novartis.
- Mullen Automotive, Inc. MULN jumped 10% to $0.2354. Mullen Automotive partnered with Loop Global to deploy EV charging solutions, including public DC fast charging network and residential offerings.
- QualTek Services Inc. QTEK gained 9.3% to $0.5463.
- Cytokinetics, Incorporated CYTK jumped 7.6% to $41.27. The FDA's Cardiovascular and Renal Drugs Advisory Committee voted 8-3 against the approval of Cytokinetics heart failure drug, omecamtiv mecarbil.
- Processa Pharmaceuticals, Inc. PCSA gained 6.3% to $2.02. Processa Pharmaceuticals said PCS12852 successfully improves the clinical symptoms associated with gastroparesis in Phase 2A trial.
Losers
- Drive Shack Inc. DS fell 55.3% to $0.2126. The company announced its intention to voluntarily delist from the NYSE and to deregister its common stock.
- ZyVersa Therapeutics Inc ZVSA dipped 36.5% to $4.76.
- Netcapital Inc. NCPL shares dipped 33.3% to $1.47 after the company announced pricing of a public offering.
- OpGen, Inc. OPGN fell 29.8% to $0.1621. OpGen shares jumped around 85% on Tuesday after the company announced topline data from its Unyvero urinary tract infections (UTI) clinical trial.
- Puhui Wealth Investment Management Co., Ltd. PHCF fell 25.7% to $2.95.
- Kaspien Holdings Inc. KSPN fell 24.2% to $0.7490 after the company reported a wider Q3 loss.
- Versus Systems Inc. VS declined 23.1% to $0.5998.
- SeqLL Inc. SQL dropped 21.7% to $0.3789.
- Vincerx Pharma, Inc. VINC declined 21.7% to $0.83.
- Avadel Pharmaceuticals plc AVDL fell 20.9% to $6.52.
- Getaround, Inc. GETR fell 20.4% to $1.09.
- Bit Brother Limited BTB dropped 20% to $0.4238 after the company announced a 1-for-15 reverse share split.
- Oriental Culture Holding LTD OCG declined 18.8% to $0.71.
- Yumanity Therapeutics, Inc. YMTX fell 16.8% to $1.6886. Yumanity Therapeutics recently declared a special dividend in connection with the proposed asset sale to Janssen and merger with Kineta.
- Baudax Bio, Inc. BXRX fell 16.6% to $2.5925.
- Summit Therapeutics Inc. SMMT fell 16.4% to $3.2691.
- Bright Health Group, Inc. BHG dropped 16% to $0.6137. Goldman Sachs, on Tuesday, downgraded Bright Health from Neutral to Sell.
- Arqit Quantum Inc. ARQQ fell 14.7% to $5.33 after the company reported FY22 results and filed for a mixed shelf of up to $100 million..
- Charter Communications, Inc. CHTR fell 13.3% to $340.65 after it communicated an increase in 2023 capital expenditures at its analyst day held on Tuesday.
- Rubicon Technology, Inc. RBCN shares fell 13.1% to $1.5814. Rubicon Technology announced voluntary delisting from the Nasdaq.
- Nexalin Technology, Inc. NXL fell 11.1% to $1.7250.
- Dragonfly Energy Holdings Corp. DFLI dropped 11% to $12.32.
- LAVA Therapeutics N.V. LVTX fell 9.4% to $4.20. LAVA Therapeutics announced updated data from the Phase 1/2a clinical trial of LAVA-051 at the 64th American Society of Hematology Annual Meeting and Exposition.
- Panbela Therapeutics, Inc. PBLA fell 7.1% to $0.1327 after gaining around 53% on Tuesday. Panbela received EMA opinion on orphan designation for Ivospemin in combination with Gemcitabine and nab-paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma.
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