Top 25 College Hoops Picks Against the Spread - Thursday, March 21

Ranked teams will be on Thursday's college basketball schedule for 13 games, including the McNeese Cowboys taking on the Gonzaga Bulldogs. Continue scrolling for ATS picks for each matchup.

Place your bets on any college basketball matchup at FanDuel, and sign up with our link for a first-time offer!

AP Top 25 Picks ATS Today

No. 21 BYU Cougars vs. Duquesne Dukes

Spread Prediction

  • Computer Prediction: BYU 76, Duquesne 69
  • Projected Favorite: BYU by 7.0 points
  • Pick ATS: Duquesne (+9.5)

Bet on the BYU-Duquesne spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 12:40 PM ET
  • Location: Omaha, Nebraska
  • Venue: CHI Health Center Omaha
  • TV Channel: truTV
  • Live Stream: truTV

No. 11 Creighton Bluejays vs. Akron Zips

Spread Prediction

  • Computer Prediction: Creighton 78, Akron 67
  • Projected Favorite: Creighton by 11.1 points
  • Pick ATS: Akron (+13.5)

Bet on the Creighton-Akron spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 1:30 PM ET
  • Location: Pittsburgh, Pennsylvania
  • Venue: PPG Paints Arena
  • TV Channel: TNT
  • Live Stream: Watch this game on Max

No. 9 Arizona Wildcats vs. Long Beach State Beach

Spread Prediction

  • Computer Prediction: Arizona 89, Long Beach State 67
  • Projected Favorite: Arizona by 22.2 points
  • Pick ATS: Arizona (-19.5)

Bet on the Arizona-Long Beach State spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 2:00 PM ET
  • Location: Salt Lake City, Utah
  • Venue: Delta Center
  • TV Channel: TBS
  • Live Stream: Watch this game on Max

No. 5 North Carolina Tar Heels vs. Wagner Seahawks

Spread Prediction

  • Computer Prediction: North Carolina 81, Wagner 57
  • Projected Favorite: North Carolina by 24.3 points
  • Pick ATS: Wagner (+24.5)

Bet on the North Carolina-Wagner spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 2:45 PM ET
  • Location: Charlotte, North Carolina
  • Venue: Spectrum Center
  • TV Channel: CBS
  • Live Stream: Watch this game on Fubo (regional restrictions may apply)

No. 10 Illinois Fighting Illini vs. Morehead State Eagles

Spread Prediction

  • Computer Prediction: Illinois 81, Morehead State 67
  • Projected Favorite: Illinois by 13.7 points
  • Pick ATS: Illinois (-11.5)

Bet on the Illinois-Morehead State spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 3:10 PM ET
  • Location: Omaha, Nebraska
  • Venue: CHI Health Center Omaha
  • TV Channel: truTV
  • Live Stream: truTV

No. 16 South Carolina Gamecocks vs. Oregon Ducks

Spread Prediction

  • Computer Prediction: Oregon 72, South Carolina 71
  • Projected Favorite: Oregon by 0.3 points
  • Pick ATS: Oregon (+1.5)

Bet on the South Carolina-Oregon spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 4:00 PM ET
  • Location: Pittsburgh, Pennsylvania
  • Venue: PPG Paints Arena
  • TV Channel: TNT
  • Live Stream: Watch this game on Max

No. 12 Kentucky Wildcats vs. Oakland Golden Grizzlies

Spread Prediction

  • Computer Prediction: Kentucky 86, Oakland 74
  • Projected Favorite: Kentucky by 12.1 points
  • Pick ATS: Oakland (+13.5)

Bet on the Kentucky-Oakland spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 7:10 PM ET
  • Location: Pittsburgh, Pennsylvania
  • Venue: PPG Paints Arena
  • TV Channel: CBS
  • Live Stream: Watch this game on Fubo (regional restrictions may apply)

No. 18 Gonzaga Bulldogs vs. McNeese Cowboys

Spread Prediction

  • Computer Prediction: Gonzaga 77, McNeese 71
  • Projected Favorite: Gonzaga by 6.3 points
  • Pick ATS: McNeese (+6.5)

Bet on the Gonzaga-McNeese spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 7:25 PM ET
  • Location: Salt Lake City, Utah
  • Venue: Delta Center
  • TV Channel: TBS
  • Live Stream: Watch this game on Max

No. 4 Iowa State Cyclones vs. South Dakota State Jackrabbits

Spread Prediction

  • Computer Prediction: Iowa State 79, South Dakota State 63
  • Projected Favorite: Iowa State by 15.2 points
  • Pick ATS: South Dakota State (+15.5)

Bet on the Iowa State-South Dakota State spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 7:35 PM ET
  • Location: Omaha, Nebraska
  • Venue: CHI Health Center Omaha
  • TV Channel: truTV
  • Live Stream: truTV

No. 6 Tennessee Volunteers vs. Saint Peter's Peacocks

Spread Prediction

  • Computer Prediction: Tennessee 79, Saint Peter's 58
  • Projected Favorite: Tennessee by 21.1 points
  • Pick ATS: Saint Peter's (+21.5)

Bet on the Tennessee-Saint Peter's spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 9:20 PM ET
  • Location: Charlotte, North Carolina
  • Venue: Spectrum Center
  • TV Channel: TNT
  • Live Stream: Watch this game on Max

No. 22 Texas Tech Red Raiders vs. NC State Wolfpack

Spread Prediction

  • Computer Prediction: Texas Tech 75, NC State 72
  • Projected Favorite: Texas Tech by 3.5 points
  • Pick ATS: NC State (+4.5)

Bet on the Texas Tech-NC State spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 9:40 PM ET
  • Location: Pittsburgh, Pennsylvania
  • Venue: PPG Paints Arena
  • TV Channel: CBS
  • Live Stream: Watch this game on Fubo (regional restrictions may apply)

No. 17 Kansas Jayhawks vs. Samford Bulldogs

Spread Prediction

  • Computer Prediction: Kansas 78, Samford 73
  • Projected Favorite: Kansas by 5.1 points
  • Pick ATS: Samford (+6.5)

Bet on the Kansas-Samford spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 9:55 PM ET
  • Location: Salt Lake City, Utah
  • Venue: Delta Center
  • TV Channel: TBS
  • Live Stream: Watch this game on Max

No. 25 Washington State Cougars vs. Drake Bulldogs

Spread Prediction

  • Computer Prediction: Washington State 74, Drake 73
  • Projected Favorite: Washington State by 0.7 points
  • Pick ATS: Washington State (+1.5)

Bet on the Washington State-Drake spread—or any other NCAA men's basketball matchup—with FanDuel!

Key Facts

  • Time: 10:05 PM ET
  • Location: Omaha, Nebraska
  • Venue: CHI Health Center Omaha
  • TV Channel: truTV
  • Live Stream: truTV

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