Top Percentage Gainers and Losers as of 2pm 5/12/11 (DSCO, OXGN, QCOR, QTWW, SNSS, RPTP, VICL, ORBK, PNSN, SPMD, CLWR, DEXO, CCIH, TNGN, NQ, SYMX, BAC, INTC)

1) Discovery Laboratories

: Trading up 21.1% from yesterday's close to $2.63. Discovery reported a Q1 loss of $0.21 per share versus estimates of a $0.33 loss. Sales came in at $381,000 versus estimates of $0. 2) OXiGENE

: Trading up 19.4% from yesterday's close to $5.85. OXiGENE announced that a Phase 1 study of 0X14503 to treat patients with acute myelogenous leukemia (or myelodysplastic syndrome) has been initiated at the University of Florida. Yesterday, the company received a positive review in The Bedford Report. 3) Questcor Pharmaceuticals

: Trading up 16.4% from yesterday's close to $22.79. Questcor announced that it has changed a controversial stock incentive plan, which would have allowed the company to re-price executive stock options without shareholder approval. Questcor also announced that its Q2 sales of Achthar prescriptions for multiple sclerosis relapses have increased notably from the first quarter. 4) Quantum Fuel Systems Technologies Worldwide

: Trading up 15.1% from yesterday's close to $5.19. Shares have gained nearly 132% since setting a 52-week low of $2.25 on May 5th. 5) Sunesis Pharmaceuticals

: Trading up 13% from yesterday's close to $2.84. Sunesis reported net income of $0.04 per share versus a loss of $0.65 per share for the same period last year. Analysts were expecting a loss of $0.13 per share.

Raptor Pharmaceutical

: Trading up 11.5% from yesterday's close to $3.74. Raptor has been initiated with a Buy by Canaccord. The price target was set at $10.00. Vical

: Trading up 13% from yesterday's close to $4.46. Shares hit a new 52-week high of $4.48 earlier in the session. Orbotech

: Trading up 9.5% from yesterday's close to $13.87. Orbotech reported a 34% increase in Q1 revenue. The company issued revenue guidance for the full year of $560 - $580 million.

1) Penson Worldwide

: Trading down 21.4% from yesterday's close to $3.01. Shares of Penson started out the session in positive territory, but started coming under heavy selling pressure at 10:30 am EST. The stock hit a new 52-week low of $2.92 earlier in the session. 2) SuperMedia

: Trading down 13% from yesterday's close to $3.47. Shares of SuperMedia have set a new 52-week low of $3.45 in today's session. 3) Clearwire

: Trading down 12.5% from yesterday's close to $4.14. Intel

announced a plan to sell 10 million shares of Clearwire, which could begin as soon as tomorrow. 4) Dex One

: Trading down 8.9% from yesterday's close to $2.98. Shares of Dex One hit a new 52-week low of $2.89 in today's session. 5) ChinaCache International Holdings

: Trading down 9% from yesterday's close to $13.42. The target price for ChinaCache shares was cut from $24.50 to $20.30 by Bank of America

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NetQuin Mobil

: Trading down 8% from yesterday's close to $7.36. Synthesis Energy Systems

: Trading down 8.2% from yesterday's close to $2.69. Tengion

: Trading down 6.2% from yesterday's close to $2.19. Tengion reported a Q1 loss of $0.41 per share versus a $1.06 loss for the same period last year.