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Actinium Pharma (AMEX:ATNM) Stock, Option Chain

Actinium Pharma

Actinium Pharmaceuticals

Actinium Pharmaceuticals Inc is a biopharmaceutical company engaged in the development of radiotherapies for patients with cancers lacking effective treatment options. The company's proprietary technology platform utilizes monoclonal antibodies to deliver radioisotopes directly to cells of interest to kill those cells safely and effectively. Its product candidates are Iomab-B, an antibody-drug construct containing iodine 131 (I-131), used for hematopoietic stem cells transplantation in various indications and Actimab-A, an antibody-drug construct containing actinium 225 (Ac-225), currently in human clinical trials for acute myeloid leukemia.

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Actinium Pharmaceuticals, Inc. (Delaware) Common Stock

Actinium Pharmaceuticals Inc

Stephens &amp; Co. analyst Sudan Loganathan reiterates Actinium Pharma (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#AMEX">ATNM</a>) with a Overweight and maintains $5 price target.

Price Target

Reiteration

Analyst Ratings

Stephens & Co. Reiterates Overweight on Actinium Pharma, Maintains $5 Price Target

Actinium Pharmaceuticals (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#AMEX">ATNM</a>) reported quarterly losses of $(0.37) per share which missed the analyst consensus estimate of $(0.30) by 23.33 percent. This is a 24.49 percent increase over losses of $(0.49) per share from the same period last year.

Actinium Pharmaceuticals Q3 EPS $(0.37) Misses $(0.30) Estimate

HC Wainwright &amp; Co. analyst Joseph Pantginis reiterates Actinium Pharma (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#AMEX">ATNM</a>) with a Buy and maintains $4 price target.

HC Wainwright & Co. Reiterates Buy on Actinium Pharma, Maintains $4 Price Target

<h3>Gainers</h3>
<ul>
<li>TFF Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TFFP#NASDAQ">TFFP</a>) stock moved upwards by 27.9% to $2.63 during Friday's pre-market session. The company's market cap stands at $9.1 million. </li>
<li>Centene (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CNC#NYSE">CNC</a>) stock rose 12.62% to $69.4. The market value of their outstanding shares is at $36.5 billion. As per the news, the Q3 earnings report came out today. </li>
<li>Nexalin Technology (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NXL#NASDAQ">NXL</a>) shares rose 9.31% to $2.35. The market value of their outstanding shares is at $24.8 million. </li>
<li>Citius Oncology (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CTOR#NASDAQ">CTOR</a>) shares increased by 8.76% to $1.31. The company's market cap stands at $93.4 million. </li>
<li>Actinium Pharma (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#AMEX">ATNM</a>) shares increased by 8.33% to $1.82. The company's market cap stands at $56.7 million. </li>
<li>BioVie (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BIVI#NASDAQ">BIVI</a>) shares rose 8.11% to $2.93. The market value of their outstanding shares is at $23.3 million. </li>
</ul>
<h3>Losers</h3>
<ul>
<li>Monopar Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MNPR#NASDAQ">MNPR</a>) stock fell 23.9% to $24.85 during Friday's pre-market session. The company's market cap stands at $87.4 million. </li>
<li>Quince Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/QNCX#NASDAQ">QNCX</a>) stock declined by 15.97% to $1.0. The company's market cap stands at $43.2 million. </li>
<li>Bionomics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BNOX#NASDAQ">BNOX</a>) stock declined by 14.89% to $0.31. The market value of their outstanding shares is at $4.0 million. </li>
<li>Hepion Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/HEPA#NASDAQ">HEPA</a>) shares decreased by 11.01% to $0.65. The company's market cap stands at $3.7 million. </li>
<li>Dogwood Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DWTX#NASDAQ">DWTX</a>) stock fell 10.11% to $4.27. The market value of their outstanding shares is at $5.6 million. </li>
<li>Passage Bio (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PASG#NASDAQ">PASG</a>) shares decreased by 9.91% to $0.58. The market value of their outstanding shares is at $35.8 million. 
See Also: <a href="http://www.benzinga.com/money/best-healthcare-stocks/" title="www.benzinga.com/money/best-healthcare-stocks/">www.benzinga.com/money/best-healthcare-stocks/</a></li>
</ul>
This article was generated by Benzinga's automated content engine and reviewed by an editor.

BIVI

BNOX

CTOR

DWTX

HEPA

MNPR

PASG

QNCX

TFFP

12 Health Care Stocks Moving In Friday's Pre-Market Session

<h3>Gainers</h3>
<ul>
<li>TFF Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TFFP#NASDAQ">TFFP</a>) stock moved upwards by 27.9% to $2.63 during Friday's pre-market session. The market value of their outstanding shares is at $9.1 million. </li>
<li>Centene (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CNC#NYSE">CNC</a>) shares increased by 12.62% to $69.4. The market value of their outstanding shares is at $36.5 billion. As per the press release, Q3 earnings came out today. </li>
<li>Nexalin Technology (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NXL#NASDAQ">NXL</a>) shares rose 9.31% to $2.35. The company's market cap stands at $24.8 million. </li>
<li>Citius Oncology (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CTOR#NASDAQ">CTOR</a>) stock rose 8.76% to $1.31. The company's market cap stands at $93.4 million. </li>
<li>Actinium Pharma (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#AMEX">ATNM</a>) stock moved upwards by 8.33% to $1.82. The company's market cap stands at $56.7 million. </li>
<li>BioVie (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BIVI#NASDAQ">BIVI</a>) stock increased by 8.11% to $2.93. The company's market cap stands at $23.3 million. </li>
</ul>
<h3>Losers</h3>
<ul>
<li>Monopar Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MNPR#NASDAQ">MNPR</a>) shares declined by 23.9% to $24.85 during Friday's pre-market session. The market value of their outstanding shares is at $87.4 million. </li>
<li>Quince Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/QNCX#NASDAQ">QNCX</a>) stock fell 15.97% to $1.0. The company's market cap stands at $43.2 million. </li>
<li>Bionomics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BNOX#NASDAQ">BNOX</a>) stock decreased by 14.89% to $0.31. The company's market cap stands at $4.0 million. </li>
<li>Hepion Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/HEPA#NASDAQ">HEPA</a>) shares declined by 11.01% to $0.65. The market value of their outstanding shares is at $3.7 million. </li>
<li>Dogwood Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DWTX#NASDAQ">DWTX</a>) stock declined by 10.11% to $4.27. The company's market cap stands at $5.6 million. </li>
<li>Passage Bio (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PASG#NASDAQ">PASG</a>) shares declined by 9.91% to $0.58. The company's market cap stands at $35.8 million. 
See Also: <a href="http://www.benzinga.com/money/best-healthcare-stocks/" title="www.benzinga.com/money/best-healthcare-stocks/">www.benzinga.com/money/best-healthcare-stocks/</a></li>
</ul>
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Biotech

General

Actinium Pharmaceuticals Publishes Phase 3 SIERRA Trial Results Of Iomab-B In Journal Of Clinical Oncology, Highlights Success In Achieving Complete Remission And Event-Free Survival

HC Wainwright &amp; Co. analyst Joseph Pantginis maintains Actinium Pharma (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#AMEX">ATNM</a>) with a Buy and lowers the price target from $50 to $4.

5HC Wainwright & Co. Maintains Buy on Actinium Pharma, Lowers Price Target to $4

WIIM

Actinium Pharmaceuticals shares are trading higher after the company reported better-than-expected Q2 EPS results.

Actinium Pharmaceuticals (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#AMEX">ATNM</a>) reported quarterly losses of $(0.38) per share which beat the analyst consensus estimate of $(0.43) by 11.63 percent.

Actinium Pharmaceuticals Q2 2024 GAAP EPS $(0.38) Beats $(0.43) Estimate

Maxim Group analyst Jason McCarthy maintains Actinium Pharma (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#AMEX">ATNM</a>) with a Buy and lowers the price target from $30 to $5.

Maxim Group Maintains Buy on Actinium Pharma, Lowers Price Target to $5

Shares of Palantir Technologies Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PLTR#NYSE">PLTR</a>) rose sharply in today's pre-market trading after the company reported better-than-expected <a href="https://www.benzinga.com/news/earnings/24/08/40172453/palantir-q2-earnings-revenue-beat-eps-beat-customer-count-up-41-driven-by-strength-in-us-commercial">second-quarter results</a>.
Palantir reported second-quarter revenue of $678.13 million, beating the consensus estimate of $652.1 million, according to <a href="https://pro.benzinga.com/dashboard">Benzinga Pro</a>. Palantir reported second-quarter adjusted earnings of 9 cents per share, beating analyst estimates of 8 cents per share.
Palantir Technologies shares surged 9.6% to $26.40 in pre-market trading.
Here are some other stocks moving in pre-market trading.
<h3 class="wp-block-heading">Gainers</h3>
<ul>
<li>Lytus Technologies Holdings PTV. Ltd. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LYT#NASDAQ">LYT</a>) rose 79.1% to $2.56 in today's pre-market trading after dipping over 12% on Monday.</li>
<li>Lumen Technologies, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LUMN#NYSE">LUMN</a>) gained 44.8% to $3.75 in pre-market trading after the company announced it secured $5 billion in new business from companies seeking to quickly secure their fiber capacity.</li>
<li>CNS Pharmaceuticals, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CNSP#NASDAQ">CNSP</a>) gained 28.7% to $0.25 in pre-market trading after tumbling over 22% on Monday.</li>
<li>AgriFORCE Growing Systems Ltd. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AGRI#NASDAQ">AGRI</a>) jumped 27% to $0.0725 in pre-market trading after falling more than 5% on Monday.</li>
<li>Agape ATP Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ATPC#NASDAQ">ATPC</a>) shares gained 26.6% to $0.1570 in pre-market trading after dipping 18% on Monday.</li>
<li>Rxsight Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RXST#NASDAQ">RXST</a>) shares gained 22.7% to $50.00 in pre-market trading after the company posted upbeat second-quarter sales and raised its FY24 revenue forecast.</li>
<li>Serve Robotics Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SERV#NASDAQ">SERV</a>) shares rose 15.3% to $15.70 in pre-market trading after falling around 7% on Monday.</li>
<li>Lucid Group Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LCID#NASDAQ">LCID</a>) shares gained 13% to $3.39 in pre-market trading after the company reported better-than-expected second-quarter sales results and announced a $1.5 billion public investment fund commitment.</li>
<li>DDC Enterprise Limited (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/DDC#NYSE">DDC</a>) shares rose 10.8% to $0.5159 in pre-market trading following around 13% surge on Monday.</li>
</ul>
<h3 class="wp-block-heading">Losers</h3>
<ul>
<li>SunPower Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SPWR#NASDAQ">SPWR</a>) shares dipped 24.6% to $0.61 in pre-market trading. SunPower announced a $45 million asset sale to complete Solaria and filed Chapter 11 to maximize asset value.</li>
<li>Chegg Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CHGG#NYSE">CHGG</a>) shares declined 18.7% to $2.38 in pre-market trading following second-quarter results.</li>
<li>Actinium Pharmaceuticals, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#NASDAQ">ATNM</a>) declined 15.3% to $2.10 in pre-market trading after dipping 60% on Monday. On Monday, the FDA determined that Actinium Pharmaceuticals&#8217; Phase 3 SIERRA trial is not adequate to support a Biologics License Application (BLA) filing for Iomab-B despite its statistically significant primary endpoint.</li>
<li>ZoomInfo Technologies Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ZI#NASDAQ">ZI</a>) shares declined 15.2% to $8.31 in pre-market trading after the company reported worse-than-expected financial results for the second quarter and announced a management transition. The company announced that CFO Cameron Hyzer will step down from his role. Hyzer will remain in an advisory capacity until Oct. 7 to help facilitate a smooth transition. Graham O&#8217;Brien has been named interim CFO, effective Sept. 6.</li>
<li>Helport AI (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/HPAI#NASDAQ">HPAI</a>) shares fell 15.2% to $7.15 in pre-market trading after declining 24% on Monday.</li>
<li>TenX Keane Acquisition (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TENK#NASDAQ">TENK</a>) fell 14.1% to $31.00 pre-market trading. TenX Keane shares jumped 193% on Monday after shareholders approved the combination with Citius Pharma&#8217;s oncology subsidiary.</li>
<li>Upexi Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/UPXI#NASDAQ">UPXI</a>) fell 12.4% to $0.25 in today's pre-market trading.</li>
<li>Bluejay Diagnostics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BJDX#NASDAQ">BJDX</a>) shares fell 11.8% to $0.4010 in pre-market trading after declining 18% on Monday.</li>
<li>Trio Petroleum Corp. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/TPET#NYSE">TPET</a>) shares fell 11.2% to $0.2594 in pre-market trading after gaining more than 19% on Monday.</li>
<li>Sumitomo Mitsui Financial Group, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SMFG#NYSE">SMFG</a>) fell 10.5% to $10.80 in pre-market trading after declining around 4% on Monday.</li>
</ul>
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U.S. stocks traded lower toward the end of trading, with the S&amp;P 500 dipping more than 100 points on Monday.
The Dow traded down 2.3% to 38,852.44 while the NASDAQ fell 3.19% to 16,241.09. The S&amp;P 500 also fell, dropping, 2.64% to 5,205.37.
Leading and Lagging Sectors Industrials shares fell by just 1.4% on Monday.
In trading on Monday, information technology shares dipped by 3.5%.
Top Headline The ISM services PMI climbed to 51.4 in July from 48.8 in April and also topping market expectations of 51.
Equities Trading UP &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<ul>
<li>Kellanova &nbsp;(NYSE:<a class="ticker" href="https://www.benzinga.com/stock/K#NYSE">K</a>) shares shot up 15% to $72.49 following a report suggesting Mars is considering an acquisition of the company.</li>
<li>Shares of Sotera Health Company (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SHC#NASDAQ">SHC</a>) got a boost, surging 8% to $14.21&nbsp;after the company reported better-than-expected quarterly financial results.</li>
<li>TenX Keane Acquisition &nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TENK#NASDAQ">TENK</a>) shares were also up, gaining 129% to $28.20 after shareholders approved the combination with Citius Pharma&#8217;s oncology subsidiary.</li>
</ul>
Equities Trading DOWN
<ul>
<li>Actinium Pharmaceuticals, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#NASDAQ">ATNM</a>) shares dropped 64% to $2.2001. On Monday, the FDA determined that Actinium Pharmaceuticals' Phase 3 SIERRA trial is not adequate to support a Biologics License Application (BLA) filing for Iomab-B despite its statistically significant primary endpoint.</li>
<li>Shares of VBI Vaccines Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VBIV#NASDAQ">VBIV</a>) were down 29% to $0.0664. VBI Vaccines was notified that its common shares will be delisted from Nasdaq effective as of opening of business on Aug. 8.</li>
<li>Concord Medical Services Holdings Limited (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CCM#NYSE">CCM</a>) was down, falling 18% to $7.22.</li>
</ul>
Commodities In commodity news, oil traded down 0.4% to $73.21 while gold traded down 0.8% at $2,449.30.
Silver traded down 3.8% to $27.315 on Monday, while copper fell 2.5% to $4.0000.
Euro zone
European shares closedlower today. The eurozone's STOXX 600 fell 2.17%, Germany's DAX fell 1.82% and France's CAC 40 fell 1.42%. Spain's IBEX 35 Index fell 2.34%, while London's FTSE 100 fell 2.04%.
Asia Pacific Markets
Asian markets closed lower on Monday, with Japan's Nikkei 225 dipping 12.4%, Hong Kong's Hang Seng Index falling 1.46%, China's Shanghai Composite Index falling 1.54% and S&amp;P BSE Sensex declining 2.74%.
Economics
<ul>
<li>The ISM services PMI climbed to 51.4 in July from 48.8 in April and also topping market expectations of 51.</li>
<li>The S&amp;P Global composite PMI was revised lower to 54.3 in July versus the preliminary reading of 55.</li>
</ul>
Now Read This: 
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<li><a href="https://www.benzinga.com/markets/24/08/40142776/wall-streets-most-accurate-analysts-views-on-3-materials-stocks-delivering-high-dividend-yields">Wall Street&#8217;s Most Accurate Analysts&#8217; Views On 3 Materials Stocks Delivering High-Dividend Yields</a></li>
</ul>

S&P 500 Down Over 100 Points; Actinium Pharmaceuticals Shares Plunge

U.S. stocks traded lower midway through trading, with the Dow Jones falling more than 950 points on Monday.
The Dow traded down 2.44% to 38,767.64 while the NASDAQ fell 3.12% to 16,252.09. The S&amp;P 500 also fell, dropping, 2.71% to 5,201.74.
Leading and Lagging Sectors Real estate shares fell by just 0.5% on Monday.
In trading on Monday, information technology shares dipped by 3.2%.
Top Headline The ISM services PMI climbed to 51.4 in July from 48.8 in April and also topping market expectations of 51.
Equities Trading UP &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<ul>
<li>Kellanova &nbsp;(NYSE:<a class="ticker" href="https://www.benzinga.com/stock/K#NYSE">K</a>) shares shot up 13% to $71.36 following a report suggesting Mars is considering an acquisition of the company.</li>
<li>Shares of Sotera Health Company (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SHC#NASDAQ">SHC</a>) got a boost, surging 10% to $14.57&nbsp;after the company reported better-than-expected quarterly financial results.</li>
<li>Sonic Automotive, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SAH#NYSE">SAH</a>) shares were also up, gaining 9% to $60.76 following better-than-expected earnings.</li>
</ul>
Equities Trading DOWN
<ul>
<li>Actinium Pharmaceuticals, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#NASDAQ">ATNM</a>) shares dropped 74% to $1.5850. On Monday, the FDA determined that Actinium Pharmaceuticals' Phase 3 SIERRA trial is not adequate to support a Biologics License Application (BLA) filing for Iomab-B despite its statistically significant primary endpoint.</li>
<li>Shares of VBI Vaccines Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VBIV#NASDAQ">VBIV</a>) were down 34% to $0.0620. VBI Vaccines was notified that its common shares will be delisted from Nasdaq effective as of opening of business on Aug. 8.</li>
<li>Concord Medical Services Holdings Limited (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CCM#NYSE">CCM</a>) was down, falling 26% to $6.56.</li>
</ul>
Commodities In commodity news, oil traded down 0.2% to $73.36 while gold traded down 0.8% at $2,449.30.
Silver traded down 3.2% to $27.49 on Monday, while copper fell 1.7% to $4.0350.
Euro zone
European shares were lower today. The eurozone's STOXX 600 fell 2.30%, Germany's DAX fell 2.01% and France's CAC 40 fell 1.63%. Spain's IBEX 35 Index fell 2.35%, while London's FTSE 100 fell 2.11%.
Asia Pacific Markets
Asian markets closed lower on Monday, with Japan's Nikkei 225 dipping 12.4%, Hong Kong's Hang Seng Index falling 1.46%, China's Shanghai Composite Index falling 1.54% and S&amp;P BSE Sensex declining 2.74%.
Economics
<ul>
<li>The ISM services PMI climbed to 51.4 in July from 48.8 in April and also topping market expectations of 51.</li>
<li>The S&amp;P Global composite PMI was revised lower to 54.3 in July versus the preliminary reading of 55.</li>
</ul>
Now Read This: <a href="https://www.benzinga.com/markets/24/08/40142776/wall-streets-most-accurate-analysts-views-on-3-materials-stocks-delivering-high-dividend-yields"> Wall Street&#8217;s Most Accurate Analysts&#8217; Views On 3 Materials Stocks Delivering High-Dividend Yields</a>

On Monday, the FDA determined that Actinium Pharmaceuticals, Inc.&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#NYSE">ATNM</a>)&nbsp;Phase 3 SIERRA trial is not adequate to support a Biologics License Application&nbsp;(BLA) filing for Iomab-B despite its statistically <a target="_blank" href="https://www.benzinga.com/news/23/02/30986777/whats-going-on-with-actinium-pharmaceuticals-stock" rel="noreferrer noopener">significant primary endpoint</a>.
The company announced a regulatory update on its planned BLA Biologics License Application seeking approval for Iomab-B in patients with active relapsed or refractory <a target="_blank" href="https://www.benzinga.com/pressreleases/24/08/n40156635/actinium-provides-regulatory-update-on-planned-bla-filing-and-future-plans-for-iomab-b-in-the-u-s" rel="noreferrer noopener">acute myeloid leukemia (r/r AML)</a>.
The FDA has advised Actinium to conduct a head-to-head study to evaluate allogeneic bone marrow transplant (BMT) using Iomab-B plus a reduced intensity conditioning regimen of fludarabine and total body irradiation (Flu/TBI) versus allogeneic BMT using reduced intensity conditioning comprised of cyclophosphamide plus Flu/TBI, a difference from the SIERRA trial, which had allowed physician&#8217;s choice of salvage therapies and heterogenous conditioning regimens in the control arm.
Additionally, the proposed new study will not allow patients to crossover from the control arm, which was allowed in the SIERRA trial and confounded the overall survival analysis in the intent-to-treat (ITT) patient population, as nearly 60% of patients <a target="_blank" href="https://www.benzinga.com/general/biotech/22/10/29483275/actinium-shares-are-trading-higher-after-positive-data-from-acute-myeloid-leukemia-trial" rel="noreferrer noopener">crossed over from the control arm</a>.
In&nbsp;February 2023, Actinium announced that the SIERRA trial met the primary endpoint with statistical significance as 22% of patients (13/76) on the Iomab-B arm achieved dCR compared to 0% of patients (0/77).
The SIERRA trial was conducted in accordance with guidance from the FDA&#8217;s End of Phase 2 meeting, which stated that positive results for dCR as the primary endpoint would be acceptable to support an Iomab-B BLA filing.
SIERRA did not meet the secondary endpoint of overall survival on an intent-to-treat basis analysis due to the high crossover rate, with nearly 60% of control arm patients receiving Iomab-B followed by a BMT.
Upon concluding its interactions with the FDA, Actinium will seek a strategic partner for Iomab-B in the U.S.
Price Action: ATNM stock is down 74% at $1.59 at last check Monday.
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U.S. stocks traded lower this morning, with the Dow Jones falling more than 2% on Monday.
The Dow traded down 2.18% to 38,872.06 while the NASDAQ fell 3.14% to 16,248.99. The S&amp;P 500 also fell, dropping, 2.54% to 5,211.01.
Leading and Lagging Sectors Real estate shares fell by just 0.9% on Monday.
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Top Headline Tyson Foods, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/TSN#NYSE">TSN</a>) reported better-than-expected third-quarter earnings on Monday.
Quarterly adjusted earnings per share of 87 cents (+480%) beat the street view of 65 cents. Sales of $13.353 billion (+1.6%) beat the analyst consensus of $13.236 billion.
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Equities Trading DOWN
<ul>
<li>Actinium Pharmaceuticals, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#NASDAQ">ATNM</a>) shares dropped 72% to $1.7006 after the FDA determined that its Phase 3 SIERRA trial is not adequate to support a BLA filing for Iomab-B.</li>
<li>Shares of VBI Vaccines Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VBIV#NASDAQ">VBIV</a>) were down 34% to $0.0615. VBI Vaccines was notified that its common shares will be delisted from Nasdaq effective as of opening of business on Aug. 8.</li>
<li>Urgent.ly Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ULY#NASDAQ">ULY</a>) was down, falling 32% to $0.9699. Urgently will host a conference call on Monday, Aug. 12 to discuss its financial results for the second quarter.</li>
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Commodities In commodity news, oil traded down 0.5% to $73.05 while gold traded down 1.5% at $2,433.40.
Silver traded down 4% to $27.265 on Monday, while copper fell 2.1% to $4.0160.
Euro zone
European shares were lower today. The eurozone's STOXX 600 fell 2.5%, Germany's DAX fell 2.5% and France's CAC 40 fell 2.1%. Spain's IBEX 35 Index fell 2.5%, while London's FTSE 100 fell 2.6%.
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Asian markets closed lower on Monday, with Japan's Nikkei 225 dipping 12.4%, Hong Kong's Hang Seng Index falling 1.46%, China's Shanghai Composite Index falling 1.54% and S&amp;P BSE Sensex declining 2.74%.
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<li>The S&amp;P Global composite PMI was revised lower to 54.3 in July versus the preliminary reading of 55.</li>
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<ul>
<li>Additional head-to-head randomized clinical trial demonstrating overall survival benefit with Iomab-B is required by FDA to support a BLA filing.</li>
<li>Actinium to request a meeting with the FDA to further discuss specifics of additional trial.</li>
<li>Actinium will seek strategic partner for Iomab-B in the U.S. following completion of FDA interactions and focus development efforts on Actimab-A, Iomab-ACT and preclinical programs</li>
</ul>

FDA Determines That Actinium Pharmaceuticals' Phase 3 Sierra Trial Is Not Adequate To Support A BLA Filing For Iomab-B For Relapsed Or Refractory Acute Myeloid Leukemia, Despite Its Statistically Significant Primary Endpoint

Actinium shares are trading lower after the FDA determined that its Phase 3 SIERRA trial is not adequate to support a BLA filing for Iomab-B.

Actinium Pharmaceuticals Received U.S. Patent Extending Into 2040 And Covers Methods Using Iomab-ACT For Conditioning Patients Prior To The Administration Of Gene-edited Hematopoietic Stem Cell Therapy To Treat Non-malignant Disorders

HC Wainwright &amp; Co. analyst Joseph Pantginis reiterates Actinium Pharma (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/ATNM#AMEX">ATNM</a>) with a Buy and maintains $50 price target.

HC Wainwright & Co. Reiterates Buy on Actinium Pharma, Maintains $50 Price Target

Collaboration With Columbia University Aims To Broaden Access To Cellular Therapies And Inform Gene Therapy Conditioning Study

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Actinium Pharmaceuticals Inc (ATNM) Targets Breakthrough in Cancer Therapy: Proprietary Production of Vital Isotope Sparks Industry Buzz and Share Surge

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SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Actinium Pharmaceuticals, Inc. - ATNM

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Actinium Pharmaceuticals Announces Publication of Results from the Phase 3 SIERRA Trial of Iomab-B in the Journal of Clinical Oncology

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