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Ionis Pharmaceuticals (NASDAQ:IONS) Stock, Option Chain

Ionis Pharmaceuticals

Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and partner Biogen brought Spinraza to market in 2016 as a treatment for a rare neuromuscular disorder, spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024.

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BIIB

IONS

Denali&#39;s DNL343 missed efficacy goals in the HEALEY ALS trial but was well-tolerated. Analysts await detailed biomarker data and subgroup analyses in 2025.

Denali Therapeutics&#39; Amyotrophic Lateral Sclerosis Misses Pivotal Trial, But Analyst Says It Was Expected

Initiation

Trading Ideas

ALNY

RARE

William Blair starts coverage on Denali Therapeutics with an Outperform rating, citing its transport vehicle platform and promising therapies for neurodegenerative diseases.

Denali Therapeutics Neurodegenerative Disease Platform Sparks Analyst Optimistic

Ionis&#39; Tryngolza receives FDA approval for familial chylomicronemia syndrome, showing significant triglyceride reduction and fewer pancreatitis events.

FDA Approves Ionis Pharmaceuticals&#39; Rare Genetic Disease Therapy to Lower High-Level Of Fat In Blood

Ionis Pharmaceuticals, Inc. - Common Stock

Ionis Pharmaceuticals Inc

Trading Halt: Halted at 7:50:00 p.m. ET - Trading Halt: Halt News Pending

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CDTTW

Amazon.com (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMZN#NASDAQ">AMZN</a>) has outperformed the market over the past 15 years by 15.64% on an annualized basis producing an average annual return of 27.78%. Currently, Amazon.com has a market capitalization of $2.47 trillion. 
Buying $100 In AMZN: If an investor had bought $100 of AMZN stock 15 years ago, it would be worth $3,745.32 today based on a price of $234.56 for AMZN at the time of writing.
<h3>Amazon.com's Performance Over Last 15 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1737762309_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

AMZN

$100 Invested In Amazon.com 15 Years Ago Would Be Worth This Much Today

Philadelphia Eagles wide receiver A.J. Brown, one of the highest-paid players in the NFL, has been making headlines lately – not just for his on-field talent but for his unassuming lifestyle choices. Brown, who signed a $96 million contract extension last offseason, surprised fans when he pulled up to a playoff game in a modest $30,000 Honda Accord.
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
<div class="wp-block-embed__wrapper">
<blockquote class="twitter-tweet" data-width="500" data-dnt="true">100 million dollar receiver AJ Brown is going viral for pulling up in a $30,000 Honda to todays game <a href="https://t.co/aqJPn6YPp7">pic.twitter.com/aqJPn6YPp7</a>
&mdash; SAY CHEESE! &#x1f444;&#x1f9c0; (@SaycheeseDGTL) <a href="https://twitter.com/SaycheeseDGTL/status/1881055447572271317?ref_src=twsrc%5Etfw">January 19, 2025</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
</figure>
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While luxury cars are often the norm for athletes of his caliber, Brown's decision sparked a wave of admiration on social media. Many praised him for staying grounded despite his wealth. One <a href="https://x.com/Talmadge18/status/1881084987363192934">tweet</a> by wealth manager Adam Talmadge summed up the sentiment: "This should be praised, not shamed! 78% of NFL players experience financial stress within two years of leaving the league. Warren Buffett drives a 2014 Cadillac XTS! I see a man who understands financial responsibility."
The comparison to billionaire investor Warren Buffett isn't far off. Buffett, famously frugal, <a href="https://www.benzinga.com/general/24/05/39040353/warren-buffett-drives-10-year-old-cadillac-bought-with-hail-damage">still drives a 2014 Cadillac XTS</a> he purchased with hail damage and lives in the same modest Omaha home he <a href="https://www.benzinga.com/news/24/09/41107810/billionaire-warren-buffett-still-lives-in-an-old-corner-house-he-purchased-for-32k-i-couldnt-imagine">bought in 1958 for $31,500</a>. Like Buffett, Brown's choice reflects a financial discipline rare in professional sports.
Trending: It&#8217;s no wonder Jeff Bezos holds over $70 million in art — <a href="https://www.benzinga.com/money/masterworks">this alternative asset has outpaced the S&amp;P 500 since 1995, delivering an average annual return of 11.4%. Here&#8217;s how everyday investors are getting started.</a>
<h2 class="wp-block-heading">A Viral Moment That Resonates</h2>
This isn't the first time Brown has gone viral during the NFL playoffs. In the Eagles' Wild Card win over the Green Bay Packers, cameras caught him reading a self-help book, Inner Excellence by Jim Murphy, on the sidelines. The moment resonated so much with fans that it <a href="https://www.benzinga.com/general/psychology/25/01/42964097/nfl-star-helps-self-help-book-hit-1-on-amazon-my-teammates-call-it-the-recipe">catapulted the book to #1</a> on Amazon's charts. Brown explained that the book, which focuses on mental toughness and peak performance, helps him stay sharp on and off the field.
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">AJ Brown is reading a book on the sideline? &#x1f4da;&#x1f602; &#x1f4fa; FOX <a href="https://t.co/jQGv8smD9N">pic.twitter.com/jQGv8smD9N</a>
&mdash; FOX Sports: NFL (@NFLonFOX) <a href="https://twitter.com/NFLonFOX/status/1878597906321609099?ref_src=twsrc%5Etfw">January 13, 2025</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
</figure>
Brown's grounded approach to finances and mental health has won him admiration beyond football. In a league where players are often pressured to flaunt their wealth, his modest car and sideline reading habit symbolize his focus on long-term well-being.
See Also: Maker of the $60,000 foldable home has 3 factory buildings, 600+ houses built, and big plans to solve housing —<a href="https://www.benzinga.com/money/boxabl"> you can become an investor for $0.80 per share today.</a>
<h2 class="wp-block-heading">Why It Matters</h2>
Brown's actions remind us that wealth doesn't have to result in flashy spending. Statistics show that many NFL players face financial difficulties shortly after retirement, highlighting the importance of financial literacy and responsibility. Brown sets an example for athletes and fans by choosing a reliable and affordable car.
Buffett has often said that additional spending doesn't significantly improve the quality of life after a certain level of comfort. Similarly, Brown's decisions – from his car to his mental game – demonstrate a commitment to living intentionally, even in a world where excess is often celebrated.
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<li>‘Scrolling To UBI' — Deloitte's #1 fastest-growing software company allows users to earn money on their phones. <a href="https://www.benzinga.com/money/mode-mobile-2">You can invest today for just $0.26/share with a $1000 minimum.</a></li>
</ul>

$100 Million Receiver AJ Brown Goes Viral Again. This Time For Arriving In A $30,000 Honda Drawing Warren Buffett Comparisons

Encompass Health (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EHC#NYSE">EHC</a>) has outperformed the market over the past 15 years by 1.26% on an annualized basis producing an average annual return of 13.39%. Currently, Encompass Health has a market capitalization of $9.63 billion. 
Buying $1000 In EHC: If an investor had bought $1000 of EHC stock 15 years ago, it would be worth $6,679.64 today based on a price of $95.66 for EHC at the time of writing.
<h3>Encompass Health's Performance Over Last 15 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1737761410_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Here's How Much $1000 Invested In Encompass Health 15 Years Ago Would Be Worth Today

Nike (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NKE#NYSE">NKE</a>) has outperformed the market over the past 20 years by 1.53% on an annualized basis producing an average annual return of 10.03%. Currently, Nike has a market capitalization of $109.48 billion. 
Buying $100 In NKE: If an investor had bought $100 of NKE stock 20 years ago, it would be worth $679.40 today based on a price of $73.55 for NKE at the time of writing.
<h3>Nike's Performance Over Last 20 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1737760520_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Here's How Much $100 Invested In Nike 20 Years Ago Would Be Worth Today

LGTY

Trading Halt: Halt status updated at 6:15:00 PM ET: Quotation Resumption: News and Resumption Times

United Airlines Holdings (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/UAL#NASDAQ">UAL</a>) has outperformed the market over the past 15 years by 2.96% on an annualized basis producing an average annual return of 15.09%. Currently, United Airlines Holdings has a market capitalization of $34.55 billion. 
Buying $1000 In UAL: If an investor had bought $1000 of UAL stock 15 years ago, it would be worth $8,585.45 today based on a price of $105.05 for UAL at the time of writing.
<h3>United Airlines Holdings's Performance Over Last 15 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1737758709_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Here's How Much You Would Have Made Owning United Airlines Holdings Stock In The Last 15 Years

OpenAI on Thursday released a research preview of a new AI agent called &#8220;Operator,&#8221; which uses the internet <a href="https://www.benzinga.com/topic/artificial-intelligence">to perform a range of tasks</a>. 
Analysts are weighing in on which publicly traded companies could benefit <a href="https://www.benzinga.com/media/24/11/41964846/openais-operator-ai-agent-will-perform-tasks-like-coding-travel-booking-and-more-launch-expected-in-january-next-year-report">from the collaboration</a>.
Expert Ideas: Bank of America Securities analysts, led by Michael McGovern, highlighted Operator's capabilities. For example, it can:
<ul>
<li>Book rides from Uber Technologies, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/UBER#NYSE">UBER</a>)</li>
<li>Order from restaurants using DoorDash (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DASH#NASDAQ">DASH</a>) and</li>
<li>Add items to an order on Maplebear, Inc.'s (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CART#NASDAQ">CART</a>) Instacart platform. </li>
</ul>
Read Next: <a href="https://www.benzinga.com/trading-ideas/movers/25/01/43136971/will-soundhound-ai-stock-get-a-boost-from-project-stargate">Will SoundHound AI Stock Get A Boost From Project Stargate?&nbsp;</a>
BofA pointed to OpenAI's demonstration of Operator which shows the AI agent ordering food from Instacart using a recipe to add each ingredient to the shopping cart. The firm sees AI agents as especially helpful with "complex basket-building" of online grocery orders.&nbsp;
"In our view, grocery ordering online could become significantly easier with AI Agents, and expect DASH &amp; Uber would likely have the most relative benefit," the analysts wrote.&nbsp;&nbsp;
The collaborations with Uber, Instacart and DoorDash are in the early stages and BofA expects the possibility of long-term partnerships allowing for more streamlined and/or additional services offered. &nbsp;
OpenAI said that Operator employs a "Computer-Using Agent" model, which integrates GPT-4o's vision capabilities with advanced reasoning through reinforcement learning. This allows it to interact with graphical user interfaces (GUIs) without custom API integrations.
Operator is currently available to subscribers of OpenAI&#8217;s $200-per-month Pro tier in the U.S. and BofA expects expansion to subscribers on the $20-per-month tier later in 2025.  
Read Next:&nbsp;
<ul>
<li><a href="https://www.benzinga.com/news/large-cap/25/01/43106379/trump-reverses-bidens-ai-policies-on-day-1-what-it-means-for-tech-giants-nvidia-amd-alphabet">Trump Reverses Biden&#8217;s AI Policies On Day 1: What It Means For Tech Giants Nvidia, AMD, Alphabet&nbsp;</a></li>
</ul>
Image: Shutterstock

Travel

Tech

CART

DASH

UBER

OpenAI's AI Agent Operator Could Boost Instacart, Uber, DoorDash: Analyst

Trading Halt: Halted at 5:35:47 p.m. ET - Trading Halt: Halt News Pending

On January 23, 2025, HWH International Received A Notice From The Nasdaq Stock Market, Informing The Company That It Has Demonstrated Compliance With Nasdaq's Listing Rule 5550(b)(1)

Offerings

Power REIT Files For Mixed Shelf Of Up To $50M

Source Capital (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SOR#NYSE">SOR</a>), a closed-end fund ("Source"), is interested in discussing a potential merger with 180 Degree Capital Corp. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TURN#NASDAQ">TURN</a>) ("TURN"). First Pacific Advisors, LP ("FPA"), is the adviser to Source and is a registered investment adviser. FPA currently manages $27 billion, which includes $350 million1 related to its management of Source. FPA has a long history of investment excellence - of the 150 largest mutual fund families in the United States, Morningstar recently ranked FPA #2 in terms of "Average Morningstar Rating."2
We propose that TURN merge into Source in an all-stock transaction valuing TURN at 101% of net asset value per share ("NAV").3

TURN

Source Capital Proposes Merger With 180 Degree Capital Corp; Proposes That TURN Merge Into Source In An All-Stock Transaction Valuing Turn At 101% Of Net Asset Value Per Share

Kinsale Cap Gr (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/KNSL#NYSE">KNSL</a>) has outperformed the market over the past 5 years by 16.87% on an annualized basis producing an average annual return of 30.08%. Currently, Kinsale Cap Gr has a market capitalization of $10.08 billion. 
Buying $1000 In KNSL: If an investor had bought $1000 of KNSL stock 5 years ago, it would be worth $3,840.57 today based on a price of $432.64 for KNSL at the time of writing.
<h3>Kinsale Cap Gr's Performance Over Last 5 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1737757814_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

KNSL

Here's How Much $1000 Invested In Kinsale Cap Gr 5 Years Ago Would Be Worth Today

On January 21, 2025, Solid Power Operating, Inc., a wholly owned subsidiary of Solid Power, Inc. (collectively, the "Company"), and the United States Department of Energy (the "DOE") entered into an Assistance Agreement (the "Assistance Agreement"), with an effective date of January 1, 2025. The Assistance Agreement provides that the DOE will provide the Company with funding of up to $50 million for the Company's installation of equipment necessary for the continuous production of sulfide-based solid electrolyte material. The Company's cost share obligation under the Assistance Agreement is $60 million. The Company is subject to certain reporting requirements and compliance obligations under the Assistance Agreement, as set forth in more detail in the Assistance Agreement.

Contracts

SLDP

Solid Power And DOE Announced $50M Assistance Agreement For Production Of Sulfide-Based Solid Electrolyte Material, With Company Cost Share Of $60M

Press Releases

Ionis announces FDA acceptance of New Drug Application for donidalorsen for prophylactic treatment of HAE

Earnings

Ionis reports third quarter 2024 financial results

Ionis Announces Pivotal Phase 3 Trial Design for ION582 in Angelman Syndrome

Ionis to present at upcoming investor conferences

Praxis Precision Medicines to Showcase Updates from Largest Epilepsy Pipeline of Precision Epilepsy Programs at the 2024 American Epilepsy Society Annual Meeting

TRYNGOLZA™ (olezarsen) approved in U.S. as first-ever treatment for adults living with familial chylomicronemia syndrome as an adjunct to diet

Ionis to present at 43rd Annual J.P. Morgan Healthcare Conference

Praxis Precision Medicines Highlights 2025 Corporate Strategy and Business Priorities

Ionis enters new chapter in 2025 as commercial-stage biotech with multiple independent product launches anticipated and continued late-stage pipeline momentum

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