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Dow Notches New Two-Year High; Nasdaq Inches Lower

NASDAQ:DELL

Dow Withstands Dreary Data; Nasdaq Slides

Mixed Feelings on Wall Street After Disappointing Data

Barclays analyst Raimo Lenschow maintains UiPath (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PATH#NYSE">PATH</a>) with a Equal-Weight and lowers the price target from $16 to $15.

News

Price Target

Analyst Ratings

PATH

Barclays Maintains Equal-Weight on UiPath, Lowers Price Target to $15

Microvast Holdings, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MVST#NASDAQ">MVST</a>) stock is moving higher on Friday after it announced <a href="https://www.benzinga.com//node/42896348">a breakthrough</a> in the company&#8217;s True All-Solid-State Battery (ASSB) technology.
The Details: Microvast&#8217;s breakthrough in ASSB technology improves battery safety, energy capacity, and efficiency, which is important for applications such as backup power for data centers and electric school buses.
Microvast explained that traditional batteries can usually operate at voltages of 3.2V to 3.7V per cell due to the limitations of liquid electrolytes. However, the company said its new technology eliminates liquid electrolytes and allows for a single cell to achieve dozens of volts.
&#8220;By developing a technology that eliminates liquid electrolytes and prioritizes scalability, we are well-positioned to meet the evolving needs of industries requiring reliable and safe energy storage solutions,&#8221; said Yang Wu, CEO of Microvast.
The company is advancing to the pilot production phase, where it will address manufacturing challenges to deliver its ASSB technology.
See Also: <a href="https://www.benzinga.com/25/01/42917106/mind-cti-acquires-aurenz-gmbh-for-188m-to-expand-uc-analytics-capabilities">MIND CTI Expands European Footprint With $1.88M Aurenz Acquisition: Details</a>
MVST Price Action: Microvast shares are trading 33.7% higher at $2.50 as of Friday morning, according to data from <a href="https://www.benzinga.com/pro/">Benzinga Pro</a>.
Image: 1836990 from Pixabay.

Movers

MVST

What's Going On With Microvast Stock Friday?

Barclays analyst Raimo Lenschow maintains MongoDB (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MDB#NASDAQ">MDB</a>) with a Overweight and lowers the price target from $400 to $330.

Barclays Maintains Overweight on MongoDB, Lowers Price Target to $330

HC Wainwright &amp; Co. analyst Andrew Fein reiterates Dyne Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DYN#NASDAQ">DYN</a>) with a Buy and maintains $55 price target.

Reiteration

HC Wainwright & Co. Reiterates Buy on Dyne Therapeutics, Maintains $55 Price Target

Top Wall Street analysts changed their outlook on these top names. For a complete view of all analyst rating changes, including upgrades, downgrades and initiations, please see our <a href="https://www.benzinga.com/analyst-stock-ratings">analyst ratings page</a>.
<ul>
<li>Baird analyst Jon Vruwink downgraded Q2 Holdings, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/QTWO#NYSE">QTWO</a>) from Outperform to Neutral but raised the price target from $89 to $99. Q2 Holdings shares closed at $99.84 on Wednesday. <a href="https://www.benzinga.com/quote/QTWO/analyst-ratings">See how other analysts view this stock.</a></li>
<li>Citigroup analyst Jon Tower downgraded the rating for Yum! Brands, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/YUM#NYSE">YUM</a>) from Buy to Neutral and lowered the price target from $153 to $141. Yum Brands shares closed at $127.74 on Wednesday. <a href="https://www.benzinga.com/quote/YUM/analyst-ratings">See how other analysts view this stock.</a></li>
<li>Wells Fargo analyst Ike Boruchow downgraded the rating for Ross Stores, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ROST#NASDAQ">ROST</a>) from Overweight to Equal-Weight and maintained the price target of $165. Ross Stores shares closed at $154.63 on Wednesday. <a href="https://www.benzinga.com/quote/ROST/analyst-ratings">See how other analysts view this stock</a>.</li>
<li>Barclays analyst Manav Patnaik downgraded Verisk Analytics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VRSK#NASDAQ">VRSK</a>) from Overweight to Equal-Weight and maintained the price target of $310. Verisk Analytics shares closed at $280.42 on Wednesday. <a href="https://www.benzinga.com/quote/VRSK/analyst-ratings">See how other analysts view this stock</a>.</li>
<li>JP Morgan analyst Bill Peterson downgraded the rating for Joby Aviation, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/JOBY#NYSE">JOBY</a>) from Neutral to Underweight but raised the price target from $5 to $6. Joby Aviation shares closed at $9.49 on Wednesday. <a href="https://www.benzinga.com/quote/JOBY/analyst-ratings">See how other analysts view this stock.</a></li>
</ul>
Considering buying YUM stock? Here&#8217;s what analysts think: 
<figure class="wp-block-image size-large is-resized"><img loading="lazy" decoding="async" width="1024" height="587" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/01/10125340/image-61-1024x587.png" alt="" class="wp-image-728698" style="width:609px;height:auto" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/01/10125340/image-61-1024x587.png 1024w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/01/10125340/image-61-300x172.png 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/01/10125340/image-61-768x440.png 768w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/01/10125340/image-61.png 1087w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure>
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<li><a href="https://www.benzinga.com/25/01/42917071/top-2-health-care-stocks-that-are-ticking-portfolio-bombs-2">Top 2 Health Care Stocks That Are Ticking Portfolio Bombs</a></li>
</ul>

Downgrades

Markets

Trading Ideas

JOBY

QTWO

ROST

VRSK

This Yum! Brands Analyst Is No Longer Bullish; Here Are Top 5 Downgrades For Friday

Barclays analyst Raimo Lenschow maintains Jamf Holding (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/JAMF#NASDAQ">JAMF</a>) with a Equal-Weight and lowers the price target from $20 to $17.

JAMF

Barclays Maintains Equal-Weight on Jamf Holding, Lowers Price Target to $17

Shares of XTI Aerospace, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/XTIA#NASDAQ">XTIA</a>) are trading higher Friday potentially from continued momentum after the company announced a significant<a href="https://www.benzinga.com/pressreleases/25/01/n42854469/xti-aerospace-updates-shareholders-on-2025-strategy-to-strengthen-leadership-in-aviation-innovatio"> stock offering on Wednesday</a>.
What To Know: XTI is issuing 363,636,364 shares of common stock at 55 cents per share, a substantial discount from its previous trading levels. The offering, which is expected to generate gross proceeds of approximately $20 million, will close on Jan. 10 2025, pending the fulfillment of customary conditions. ThinkEquity is acting as the sole placement agent for the deal.
The company plans to use the proceeds for general working capital and corporate purposes. However, the announcement has triggered a sharp sell-off, as the market reacts to the heavy dilution resulting from the massive increase in the share count. The pricing of the offering, which is well below market value, may have further amplified concerns about shareholder value and the company's financial strategy. 
XTIA Price Action: XTI Aerospace shares were down 50.5% at $6.22 at the time of writing, according to <a href="http://www.benzinga.com/pro/register/?utm_source=BZprocontent071824&amp;t=be2bearmibe3na1">Benzinga Pro.</a>
<figure class="wp-block-image size-large is-resized"><a href="https://bzresearch.myclickfunnels.com/benzinga-pro-content-webinar-registration/?utm_source=BZprocontent011025&amp;t=be2bearmibe3na1"><img loading="lazy" decoding="async" width="1024" height="533" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/01/10113118/Screenshot-2025-01-10-at-11.30.22-1024x533.png" alt="" class="wp-image-728529" style="width:490px;height:auto" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/01/10113118/Screenshot-2025-01-10-at-11.30.22-1024x533.png 1024w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/01/10113118/Screenshot-2025-01-10-at-11.30.22-300x156.png 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/01/10113118/Screenshot-2025-01-10-at-11.30.22-768x400.png 768w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/01/10113118/Screenshot-2025-01-10-at-11.30.22-1536x800.png 1536w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/01/10113118/Screenshot-2025-01-10-at-11.30.22.png 1554w" sizes="(max-width: 1024px) 100vw, 1024px" /></a></figure>
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</ul>
Image: Shutterstock/ solarseven.

XTIA

XTI Aerospace Shares Are Surging Today: What You Need To Know

Barclays analyst Raimo Lenschow maintains Dayforce (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/DAY#NYSE">DAY</a>) with a Equal-Weight and lowers the price target from $84 to $80.

Barclays Maintains Equal-Weight on Dayforce, Lowers Price Target to $80

HC Wainwright &amp; Co. analyst Ed Arce reiterates Acurx Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ACXP#NASDAQ">ACXP</a>) with a Buy and maintains $12 price target.

ACXP

HC Wainwright & Co. Reiterates Buy on Acurx Pharmaceuticals, Maintains $12 Price Target

Companies in California and across the United States are pitching in to help consumers dealing with <a href="https://www.benzinga.com/25/01/42899953/five-dead-in-los-angeles-wildfires-utilities-face-scrutiny">wildfires in the state.</a>
What Happened: Wildfires in California have forced thousands of people to be evacuated from their homes as wildfires led to power outages and damaged properties, marking one of the potentially highest costing events in state history for the insurance industry.
Companies are pitching in to help consumers by delaying payments, offering free services and providing necessities like places to stay and food.
Here's a look at a portion of the companies offering help:
SpaceX: The company is <a href="https://www.benzinga.com/general/space/25/01/42892886/spacex-ceo-elon-musk-offers-free-starlink-terminals-to-los-angeles-areas-affected-by-wildfires">providing free Starlink</a> terminals to areas near Los Angeles impacted by the wildfires, CEO Elon Musk announced Thursday. The tweet came with a local media reporter sharing that they were using Starlink to be able to provide live coverage with a lack of cell service in the area.
Sweetgreen (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SG#NYSE">SG</a>): The restaurant chain's co-founder Nicholas Jammet <a href="https://www.linkedin.com/in/nicolas-jammet-5b9b878/?trk=public_post_embed_feed-actor-name">shared </a>a video on LinkedIn saying the company was hoping to provide food to as many people impacted by the wildfires as possible.
"We want to help, we want to feed as many people as possible," Jammet said in the video.
Starbucks (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SBUX#NASDAQ">SBUX</a>): One Starbucks location was destroyed by fires in the area, Bloomberg <a href="https://www.bloomberg.com/news/live-blog/2025-01-08/palisades-fire-near-los-angeles-latest?srnd=homepage-americas&amp;sref=TBDibEcD">reported</a>. Another location handed out coffee and food to first responders to help in the efforts.
Target Corporation (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/TGT#NYSE">TGT</a>): The retailer said is was fast-tracking critical supplies to stores near Los Angeles to help get necessary supplies to first responders and customers quicker.
Kroger (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/KR#NYSE">KR</a>): The retailer lost a location in the Palisades region from the fires. The retailer is also giving food and water to people in the fire-impacted areas.
Albertsons (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ACI#NYSE">ACI</a>): The retailer is also giving food and water to first responders in the wildfire areas.
Lyft Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LYFT#NASDAQ">LYFT</a>): The ride-share company announced it was offering free and discounted rides to and from shelters for impacted California residents.
"Lyft is committed to providing access to reliable transportation, especially in emergencies to support communities in need," Lyft Social Impact Manager Celia Moreno <a href="https://www.lyft.com/blog/posts/help-for-those-impacted-by-wildfire-in-california">said</a>.
U-Haul (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/UHAL#NYSE">UHAL</a>): The moving and storage company is offering 30 days free storage at 92 facilities located in Southern California for those impacted by the wildfires.
"People are hurting and in need of help. U-Haul is part of these communities, and if we can help our neighbors in this process, we are going to do so," U-Haul area district vice president Chris Piedra <a href="https://www.uhaul.com/Articles/About/Ca-Wildfire-Assistance-U-Haul-Offers-30-Days-Free-Storage-AT-92-Centers-33115/">said</a>.
Apple Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AAPL#NASDAQ">AAPL</a>): The technology giant is providing temporary relief for Apple Card users in the Los Angeles area, allowing people to postpone payments without interest, as <a href="https://x.com/markgurman/status/1877480784648397264?s=46">reported </a>by Bloomberg writer Mark Gurman. Apple CEO Tim Cook also announced the company will be donating to help in the wildfire efforts.
"Thank you to the incredible firefighters, first responders, and all those assisting for your heroic efforts. Apple will be donating to support the victims and recovery efforts on the ground," Cook <a href="https://x.com/tim_cook/status/1877176338651439162">tweeted</a>.
Tesla Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TSLA#NASDAQ">TSLA</a>): The electric vehicle company <a href="https://x.com/tesla_na/status/1877454782647980368">announced </a>it was forgiving Autopilot and FSD Supervised strikes to people in California to provide them with more options when evacuating the region.
Planet Fitness (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PLNT#NYSE">PLNT</a>): The gym chain is offering its locations to first responders and local residents in the impacted areas as a place to shower and charge devices through January 15, as <a href="https://www.cbsnews.com/amp/news/los-angeles-wildfires-pacific-palisades-planet-fitness-airbnb/">reported </a>by CBS News.
Airbnb (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ABNB#NASDAQ">ABNB</a>): The house rental's Airbnb.org charitable arm is helping find free temporary housing for people who had to evacuate their homes.
Toyota (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/TM#NYSE">TM</a>): The automotive company <a href="https://pressroom.toyota.com/toyota-supports-california-fires-relief-efforts/">announced </a>it would offer payment relief options to those impacted by the wildfires and is also matching donations from U.S. employees made to nonprofits like The American Red Cross.
AT&amp;T (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/T#NYSE">T</a>): The telecommunications company <a href="https://about.att.com/pages/disaster-recovery/california-fires">waived </a>overage charges and is offering unlimited talk, text and data through Feb. 6, 2025 to customers in the impacted areas.
T-Mobile (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TMUS#NASDAQ">TMUS</a>): The telecommunications company <a href="https://www.t-mobile.com/news/network/t-mobile-stands-prepared-as-wildfires-impact-southern-california">providing</a> free Wi-Fi and device charging at some retail stores in the area as well as Wi-Fi at command posts. The company is also offering unlimited talk, text and data to customers in the impacted area through Jan. 15.
DoorDash (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DASH#NASDAQ">DASH</a>): The food delivery company <a href="https://about.doordash.com/en-us/news/los-angeles-wildfires-2025">offered </a>$150,000 in community credits to first responders and organizations on the ground in the impacted regions, allowing people helping with the efforts and displaced from their homes to get food and essential supplies quickly. The company is providing relief grants for local restaurants through the Restaurant Disaster Relief Fund. A total of $250,000 is also available through the Dasher Relief Fund for eligible drivers in the region impacted by the fire.
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Photo: Shutterstock

AAPL

ABNB

DASH

LYFT

PLNT

SBUX

TMUS

TSLA

UHAL

SpaceX, Apple, Airbnb And More Companies Pitch In To Support California Residents After Wildfires: 'We Want To Help'

Mizuho analyst Vijay Rakesh maintains Intel (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/INTC#NASDAQ">INTC</a>) with a Neutral and lowers the price target from $23 to $21.

INTC

Mizuho Maintains Neutral on Intel, Lowers Price Target to $21

U.S. stocks traded lower midway through trading, with the Nasdaq Composite falling over 400 points on Friday.
The Dow traded down 1.64% to 41,935.30 while the NASDAQ dipped 2.15% to 19,060.79. The S&amp;P 500 also fell, dropping, 1.77% to 5,813.73.
Check This Out: <a href="https://www.benzinga.com/25/01/42900074/how-to-earn-500-a-month-from-synovus-financial-stock-ahead-of-q4-earnings">How To Earn $500 A Month From Synovus Financial Stock Ahead Of Q4 Earnings</a>
Leading and Lagging Sectors Energy shares rose by 0.6% on Friday.
In trading on Friday, information technology shares tumbled by 2.1%.
Top Headline
On Friday, Walgreens Boots Alliance Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WBA#NASDAQ">WBA</a>) reported better-than-expected first-quarter results.
The company posted quarterly sales of $39.46 billion, up 7.5% year over year (+6.9% on constant currency), beating the consensus of $37.28 billion, reflecting sales growth across all segments.
Adjusted EPS was 51 cents, down from 66 cents a year ago, beating the consensus of 37 cents, according to data from Benzinga Pro.
Equities Trading UP &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<ul>
<li>Conduit Pharmaceuticals Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CDT#NASDAQ">CDT</a>) shares shot up 52% to $0.12.</li>
<li>Shares of Vision Marine Technologies Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VMAR#NASDAQ">VMAR</a>)got a boost, surging 72% to $2.62 as it regained compliance with Nasdaq's minimum stockholders' equity requirement, which it previously failed to meet. Vision Marine partnered with Calip Group to produce advanced cooling plates for electric boat batteries.</li>
<li>DatChat Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DATS#NASDAQ">DATS</a>) shares were also up, gaining 107% to $6.63 after the company announced the pricing of a $5.1 million registered direct offering priced at-the-market under Nasdaq rules.</li>
</ul>
Equities Trading DOWN
<ul>
<li>IGM Biosciences Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/IGMS#NASDAQ">IGMS</a>) shares dropped 69% to $1.94 &nbsp;after the company announced it is halting further development of Imvotamab and IGM-2644.</li>
<li>Shares of XTI Aerospace Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/XTIA#NASDAQ">XTIA</a>) were down 54% to $5.82. XTI Aerospace recently announced a $20 million offering of 363,636,364 shares at $0.055 per share.</li>
<li>22nd Century Group Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/XXII#NASDAQ">XXII</a>) was down, falling 39% to $4.97.</li>
</ul>
Commodities In commodity news, oil traded up 2.4% to $75.67 while gold traded up 1% at $2,716.70.
Silver traded up 1% to $31.315 on Friday, while copper fell 0.2% to $4.2995.
Euro zone
European shares were lower today. The eurozone's STOXX 600 declined 0.79%, Germany's DAX 40 fell 0.44% and France's CAC 40 dipped 0.85%. Spain's IBEX 35 Index fell 1.43%, while London's FTSE 100 slipped 0.83%.
Asia Pacific Markets
Asian markets closed lower on Friday, with Japan's Nikkei 225 falling 1.05%, China's Shanghai Composite Index dipping 1.33%, Hong Kong's Hang Seng Index declining 0.92% and India's BSE Sensex falling 0.31%.
Economics
<ul>
<li>Nonfarm payrolls rose by 256,000 last month, up from the downwardly revised 212,000 in November and sharply surpassing economist expectations of 160,000 payrolls as tracked by TradingEconomics.</li>
<li>The unemployment rate fell from 4.2% to 4.1%, beating forecasts of an unchanged reading.</li>
<li>Average hourly earnings rose 0.3% month-over-month in December, matching expectations but slowing from November's 0.4%. On a year-over-year basis, wages increased 3.9%, slightly below of the 4% forecast.</li>
</ul>
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Equities

Eurozone

Commodities

Intraday Update

DATS

IGMS

VMAR

XXII

Nasdaq Down Over 2%; Walgreens Posts Upbeat Results

Mizuho analyst Vijay Rakesh maintains Seagate Tech Hldgs (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/STX#NASDAQ">STX</a>) with a Outperform and lowers the price target from $130 to $110.

Mizuho Maintains Outperform on Seagate Tech Hldgs, Lowers Price Target to $110

Jefferies analyst Roger Song downgrades IGM Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/IGMS#NASDAQ">IGMS</a>) from Buy to Hold and lowers the price target from $48 to $2.

Jefferies Downgrades IGM Biosciences to Hold, Lowers Price Target to $2

HC Wainwright &amp; Co. analyst Edward White maintains Inozyme Pharma (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/INZY#NASDAQ">INZY</a>) with a Buy and raises the price target from $14 to $16.

INZY

HC Wainwright & Co. Maintains Buy on Inozyme Pharma, Raises Price Target to $16

On Friday, Mersana Therapeutics Inc.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MRSN#NASDAQ">MRSN</a>) released initial data from the Phase 1 dose escalation and backfill cohorts <a target="_blank" href="https://www.benzinga.com/pressreleases/25/01/g42907652/mersana-therapeutics-announces-positive-initial-clinical-data-from-phase-1-clinical-trial-of-emilt" rel="noreferrer noopener">for emiltatug ledadotin</a>.
Emi-Le was generally well tolerated, with no Grade 4 or 5 treatment-related adverse events reported.
At intermediate doses in the trial (38.1 mg/m2&nbsp;to 67.4 mg/m2), the confirmed objective response rate among evaluable patients was 23% (6 of 26 patients) across all B7-H4 high tumors and 23% (3 of 13 patients) with B7-H4 high TNBC, all of whom had previously been treated with at least one topo-1 ADC.
In the ASCENT Phase 3 trial of sacituzumab govitecan, the ORR with standard-of-care single-agent chemotherapy in relapsed/refractory TNBC was approximately 5%, with progression-free survival of approximately seven weeks.
Based on these encouraging Emi-Le data at intermediate doses, Mersana has advanced a dose of 67.4 mg/m2&nbsp;every four weeks into an expansion cohort in patients with TNBC who have received one to four prior treatment lines.
At high doses above 76 mg/m2, the confirmed ORR among evaluable patients was 22% (2 of 9) across all B7-H4 high tumors.
Additionally, 78% (7 of 9 patients) had ≥30% tumor reduction in target lesions.
At these high dose levels, objective responses in multiple evaluable patients with B7-H4 high tumors were not confirmed after protocol-mandated dose delays for proteinuria.
Mersana is implementing proteinuria mitigation efforts and continues to examine higher doses in dose escalation and backfill cohorts to identify a second dose for the expansion portion of the trial.
Concurrently, the FDA granted an additional Fast Track designation to Mersana Therapeutics&#8217; XMT-1660.
The company also announced that the World Health Organization has approved emiltatug ledadotin (abbreviated as Emi-Le) as XMT-1660&#8217;s <a target="_blank" href="https://www.benzinga.com/pressreleases/25/01/g42907717/mersana-therapeutics-announces-additional-fda-fast-track-designation-granted-to-emiltatug-ledadoti" rel="noreferrer noopener">international nonproprietary name</a>.
The new Fast Track designation is for advanced or metastatic breast cancer in patients with human epidermal growth factor receptor 2 (HER2) low (IHC 1+ or IHC 2+/ISH–) or HER2-negative (IHC 0) disease, including triple-negative breast cancer (TNBC), who have received a prior topoisomerase-1 inhibitor ADC.
Additionally, hormone-receptor positive patients should also have received or be ineligible for endocrine therapy.
Price Action: MRSN stock is down 36.6% at $0.8245 at last check Friday.
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MRSN

Why Is Cancer-Focused Mersana Therapeutics Stock Trading Lower On Friday?

Unexpectedly strong labour market data has sparked a bearish response in crypto markets, with Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) teetering <a href="https://www.benzinga.com/markets/cryptocurrency/25/01/42913406/bitcoin-fights-to-regain-94000-what-does-technical-analysis-say">around the $94,000 mark</a>.
What Happened: Data published on Friday shows the U.S. <a href="https://www.benzinga.com/economics/macro-economic-events/25/01/42912480/us-economy-adds-256000-payrolls-in-december-as-tight-labor-market-tops-forecasts-dollar-treasury-yields-spike">added 256,000 parolls in December</a>, sending bond yields soaring and knocking Bitcoin off its morning recovery.
The apex crypto had recovered from $92,000 to $95,000 overnight, but quickly lost over $2,000 in reaction to the stronger-than-anticipated data. 
Crypto trader Jelle highlighted the abrupt shift in market sentiment, pointing out that the jobs data managed to reverse the price momentum with the words &#8220;stairs up, elevator down.&#8221;
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">Job data here to mess things up, it was stairs up, elevator down after all &#x1f602;<a href="https://twitter.com/hashtag/Bitcoin?src=hash&amp;ref_src=twsrc%5Etfw">#Bitcoin</a> <a href="https://t.co/aPbsjXZ2rK">pic.twitter.com/aPbsjXZ2rK</a>
&mdash; Jelle (@CryptoJelleNL) <a href="https://twitter.com/CryptoJelleNL/status/1877712149432144112?ref_src=twsrc%5Etfw">January 10, 2025</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
</figure>
Prominent technical analyst Kevin <a href="https://x.com/Kev_Capital_TA/status/1877712204121645076">argued</a> that the report&#8217;s strong labor market indicators—low unemployment and PCE inflation within the Federal Reserve's 2% range—are positive for the economy. 
Kevin believes the market&#8217;s negative reaction stems from an overreliance on rate cuts, even though the economy appears healthier without them.
"Report was bullish. Hopefully market comes to its senses," Kevin explained. 
Echoing a similar opinion, Charles Edwards, founder of Capriole Investments highlighted the market&#8217;s bearish overreaction to a strong employment report, which he sees as bullish in the long run.
He noted that fewer jobs would allow rates to stay high, but strong job numbers suggest the bull market could extend further. 
The report, the best in six months, quells fears of rising unemployment. E
dwards also <a href="https://x.com/caprioleio/status/1877720656995135793">pointed</a> out the extremely high intraday put-call ratio, comparable to COVID crash lows, suggesting a potential market bounce ahead.
Also Read: <a href="https://www.benzinga.com/markets/cryptocurrency/25/01/42919731/bitcoin-to-bounce-back-in-q1-but-beware-20-corrections-analysts-warn">Bitcoin To Bounce Back In Q1 But Beware 20% Corrections, Analysts Warn</a>
Why It Matters: Before the report, analysts outlined <a href="https://www.benzinga.com/markets/cryptocurrency/25/01/42909925/previewing-todays-most-important-jobs-report-what-it-means-for-bitcoin">potential market scenarios</a> based on varying unemployment outcomes.
A &#8220;hot&#8221; jobs report—defined as over 200,000 jobs added—was expected to trigger a selloff, which is precisely what happened.
Bitcoin saw whale transactions and exchange netflows dropping by 6.2% and 335%, respectively.
The It is trading at $94,400 at the time of writing, up 1.8% on the day.
Read Next:
<ul>
<li><a href="https://www.benzinga.com/markets/cryptocurrency/25/01/42913406/bitcoin-fights-to-regain-94000-what-does-technical-analysis-say">Bitcoin Fights To Regain $94,000: What Does Technical Analysis Say?</a></li>
</ul>
Image: Shutterstock

Coverage of Bitcoin, Etherum, Ripple and all the latest digital currencies.

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Bitcoin Takes 'Stairs Up' And 'Elevator Down' On Labor Market Data: What's Next?

Mizuho analyst Vijay Rakesh maintains Microchip Technology (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MCHP#NASDAQ">MCHP</a>) with a Outperform and lowers the price target from $85 to $72.

MCHP

Mizuho Maintains Outperform on Microchip Technology, Lowers Price Target to $72

Needham analyst Gil Blum reiterates Immunocore Hldgs (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/IMCR#NASDAQ">IMCR</a>) with a Buy and maintains $71 price target.

IMCR

Needham Reiterates Buy on Immunocore Hldgs, Maintains $71 Price Target

Jefferies analyst Stephanie Moore maintains XPO (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/XPO#NYSE">XPO</a>) with a Buy and raises the price target from $150 to $165.

Jefferies Maintains Buy on XPO, Raises Price Target to $165

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