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Valterra Resource Corp

Health Care

Pfizer Owned ViiV Healthcare Announces Positive Data For Dovato Which Is As Effective As 3-Drug Regimen Biktarvy For Maintenance Therapy Of HIV-1

Earnings

KB Financial Q2 Profit Attributable To Controlling Interests WON1,710.8B (+65.1% QoQ); Net Interest Income WON3,206.2B (+1.7% QoQ)

MAIA Biotechnology, Inc., (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MAIA#NYSE">MAIA</a>)&nbsp;(&quot;MAIA&quot;, the &quot;Company&quot;), a clinical-stage biopharmaceutical company developing targeted immunotherapies for cancer, today announces positive treatment updates from its Phase 2 clinical trial, THIO-101, evaluating THIO sequenced with the immune checkpoint inhibitor (CPI) cemiplimab (Libtayo&reg;) in patients with advanced non-small cell lung cancer (NSCLC) who failed two or more standard-of-care therapy regimens.
The trial&#39;s therapeutic regimen is cycled every 3 weeks, with THIO 180mg administered in 60mg incremental doses on days 1, 2 and 3, followed by immune activation on day 4 (no dosing), and cemiplimab 350mg administered on day 5. As of the latest clinical cutoff date, June 12, 2024:
<ul>
<li>6 patients remain on treatment following at least 12 months of therapy.</li>
<li>Treatment with THIO followed by cemiplimab has been well tolerated throughout the trial, with much lower toxicity compared to standard-of care treatments.</li>
<li>Continuing treatment past 12 months demonstrates safety, efficacy and ongoing benefit from MAIA&#39;s novel telomere targeting NSCLC therapy.</li>
</ul>
&quot;Our longest treated patient so far has completed 21 cycles of THIO sequenced with a CPI, and 6 patients who have crossed the 12-month survival follow-up are continuing the treatment,&quot; said Vlad Vitoc, M.D., Chairman and Chief Executive Officer of MAIA. &quot;With current therapies, second-line patients&#39; treatment duration is usually around 3-4 months1&nbsp;and third-line is even lower than that. It is very encouraging to see that our patients can remain on treatment for much longer. The ongoing benefits of THIO in longer-term patients are particularly notable, signifying THIO&#39;s potential as a durable and efficacious treatment for advanced NSCLC patients faced with limited options.&quot;
<ol>
<li><a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS0169500217304373&amp;esheet=54097974&amp;newsitemid=20240723808500&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS0169500217304373&amp;index=1&amp;md5=b49864acdcc39be65cbb0686e24c0b97">https://www.sciencedirect.com/science/article/pii/S0169500217304373</a></li>
</ol>
About THIO
THIO (6-thio-dG or 6-thio-2&#39;-deoxyguanosine) is a first-in-class investigational telomere-targeting agent currently in clinical development to evaluate its activity in Non-Small Cell Lung Cancer (NSCLC). Telomeres, along with the enzyme telomerase, play a fundamental role in the survival of cancer cells and their resistance to current therapies. The modified nucleotide 6-thio-2&#39;-deoxyguanosine (THIO) induces telomerase-dependent telomeric DNA modification, DNA damage responses, and selective cancer cell death. THIO-damaged telomeric fragments accumulate in cytosolic micronuclei and activates both innate (cGAS/STING) and adaptive (T-cell) immune responses. The sequential treatment with THIO followed by PD-(L)1 inhibitors resulted in profound and persistent tumor regression in advanced, in vivo cancer models by induction of cancer type&ndash;specific immune memory. THIO is presently developed as a second or later line of treatment for NSCLC for patients that have progressed beyond the standard-of-care regimen of existing checkpoint inhibitors.
About THIO-101, a Phase 2 Clinical Trial
THIO-101 is a multicenter, open-label, dose finding Phase 2 clinical trial. It is the first trial designed to evaluate THIO&#39;s anti-tumor activity when followed by PD-(L)1 inhibition. The trial is testing the hypothesis that low doses of THIO administered prior to cemiplimab (Libtayo&reg;) will enhance and prolong immune response in patients with advanced NSCLC who previously did not respond or developed resistance and progressed after first-line treatment regimen containing another checkpoint inhibitor. The trial design has two primary objectives: (1) to evaluate the safety and tolerability of THIO administered as an anticancer compound and a priming immune activator (2) to assess the clinical efficacy of THIO using Overall Response Rate (ORR) as the primary clinical endpoint. Treatment with cemiplimab (Libtayo&reg;) followed by THIO has been generally well-tolerated to date in a heavily pre-treated population. For more information on this Phase II trial, please visit ClinicalTrials.gov using the identifier NCT05208944.

MAIA

MAIA Biotechnology Reports Phase 2 Results for Lung Cancer Treatment THIO

The EU has put&nbsp;Meta Platforms Inc.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/META#NASDAQ">META</a>) on <a href="https://www.benzinga.com/news/24/07/39569000/metas-pay-or-consent-model-to-draw-charges-from-eu-report">notice over its &#8220;pay or consent&#8221;&nbsp;model</a> for Facebook and Instagram, citing potential violations of consumer protection laws.
What Happened: The EU&#8217;s Consumer Protection Cooperation or CPC Network has given Meta until Sept. 1, 2024, to propose changes to its <a href="https://www.benzinga.com/news/24/02/37390643/consumer-watchdogs-target-metas-pay-or-give-up-privacy-tactic-in-eu-smokescreen-to-obscure-illegal-d">&#8220;pay or consent&#8221; model</a>, according to a blog post on Tuesday.
The EU has labeled the model as &#8220;misleading&#8221; and &#8220;confusing&#8221; for users, and non-compliance could lead to fines.
&#8220;Consumer protection authorities assessed several elements that could constitute misleading or aggressive practices, in particular, whether Meta provided consumers upfront with true, clear, and sufficient information,&#8221; the union stated.
See Also:&nbsp;<a href="https://www.benzinga.com/news/24/07/39881748/elon-musks-xai-flips-the-switch-on-100k-nvidia-h100-gpus-worth-up-to-4b-in-memphis-supercluster-most?itm_source=parsely-api" target="_blank" rel="noreferrer noopener">Elon Musk&#8217;s xAI Flips The Switch On 100K Nvidia H100 GPUs Worth Up To $4B In Memphis Supercluster: &#8216;Most Powerful AI Training Cluster In The World&#8217;</a>
Meta&#8217;s &#8220;pay or consent&#8221; model, rolled out last year, presents users with two choices: pay up to €12.99 (approximately $14.13) per month for ad-free usage of Facebook and Instagram or agree to the collection and use of personal data for personalized ads.
The CPC initiated its investigation in response to complaints from consumer watchdog groups. These groups alleged that Meta employs confusing language to describe the paid and &#8220;free&#8221; versions of its platforms.
Meta did not immediately respond to <a href="https://pro.benzinga.com/dashboard">Benzinga&#8217;s</a> request for comments.
Subscribe to the&nbsp;<a href="https://bztechtrends.beehiiv.com/subscribe" target="_blank" rel="noreferrer noopener">Benzinga Tech Trends newsletter</a>&nbsp;to get all the latest tech developments delivered to your inbox.
Why It Matters: This development follows <a href="https://www.benzinga.com/government/24/03/37828545/meta-bows-down-to-eu-regulations-after-apple-and-google-cut-subscription-prices-for-ad-free-facebook">Meta&#8217;s decision to reduce the subscription</a> fee for its ad-free Facebook and Instagram services in Europe to €5.99 ($6.5) from the initial €9.99 ($10.9).
This move was aimed at addressing growing concerns of privacy and antitrust regulators.
Last month, Meta faced a&nbsp;<a href="https://www.benzinga.com/news/24/06/39307741/meta-platforms-under-fire-in-norway-for-using-private-user-data-from-facebook-instagram-for-ai-train">complaint&nbsp;in Norway for using user images</a> and posts from Facebook and Instagram to train AI models. 
The Norwegian Consumer Council argued that the opt-out process violates strict EU data protection laws and that Meta uses deceptive design patterns and vague language to make opting out difficult.
Check out more of Benzinga&#8217;s Consumer Tech coverage by&nbsp;<a href="https://www.benzinga.com/topic/consumer-tech" target="_blank" rel="noreferrer noopener">following this link</a>.
Read Next:&nbsp;
<ul>
<li><a href="https://www.benzinga.com/news/24/07/39873131/apple-skips-tsmcs-2nm-chip-for-iphone-17-unveils-first-ios-18-public-beta-and-more-this-week-in-appl?itm_source=parsely-api" target="_blank" rel="noreferrer noopener">Apple Skips TSMC&#8217;s 2nm Chip For iPhone 17, Unveils First iOS 18 Public Beta And More: This Week In Appleverse</a></li>
</ul>
Disclaimer: This content was partially produced with the help of AI tools and was reviewed and published by Benzinga editors.
Photo courtesy: Shutterstock

Social Media

Global

Tech

Meta Says Facebook Is 'Free' — EU Threatens To Fine Mark Zuckerberg-Led Social Media Giant

<ul>
<li>Divestiture Advances Johnson Controls&#39; Transformation into a&nbsp;Pure-Play Provider of Comprehensive Solutions for Commercial Buildings</li>
<li>Transaction Valued At&nbsp;$8.1 Billion; JCI Consideration of&nbsp;$6.7 Billion</li>
<li>Company Provides Preliminary 2024 Third Fiscal Quarter Earnings Update</li>
<li>The transaction includes the North America Ducted business and global Residential joint venture with Hitachi, Ltd. (&quot;Hitachi&quot;), of which Johnson Controls owns&nbsp;60%&nbsp;and Hitachi owns&nbsp;40%. The total transaction is valued at&nbsp;$8.1 billion, and the Company&#39;s portion of the consideration is approximately&nbsp;$6.7 billion. As part of the transaction, Hitachi will retain certain ductless HVAC assets located in Shimizu,&nbsp;Japan</li>
</ul>

Johnson Controls To Divest Residential And Light Commercial HVAC Businesses In $8.1B Deal With Bosch

&nbsp;Cognizant (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CTSH#NASDAQ">CTSH</a>) and Whitbread have expanded their digital transformation relationship which will see the professional services provider support the hospitality company&#39;s ongoing digital transformation with product design, product management and engineering as Whitbread expands its operations in the UK and&nbsp;Germany.

CTSH

Cognizant And Whitbread Expand Partnership To Enhance Digital Customer Experiences Across UK And Germany

Kronos Worldwide, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/KRO#NYSE">KRO</a>) (the &quot;Company&quot;) announced today that it is seeking to raise debt capital through a private offering of &euro;75 million aggregate principal amount of additional&nbsp;9.50%&nbsp;Senior Secured Notes due 2029 (the &quot;Notes&quot;) by its wholly-owned subsidiary, Kronos International, Inc. (&quot;KII&quot;). The Notes are being offered as additional notes to the existing &euro;276,174,000 aggregate principal amount of&nbsp;9.50%&nbsp;Senior Secured Notes due 2029 that KII issued on February 12, 2024 (the &quot;Existing Notes&quot;). Other than with respect to the date of issuance and issue price, the Notes will have the same terms as the Existing Notes. The Notes will be maintained under the same ISIN and Common Code numbers as the Existing Notes, except that the Notes issued pursuant to Regulation&nbsp;S under the U.S. Securities Act of 1933, as amended (the &quot;Securities Act&quot;), will trade separately under different ISIN and Common Code numbers until 40 days after the issue date of the Notes, but thereafter, the Notes issued pursuant to Regulation&nbsp;S will be maintained under the same ISIN and Common Code numbers as the Existing Notes issued pursuant to Regulation S.

Offerings

Kronos Worldwide Seeks to Raise €75M Through Additional Senior Secured Notes

<a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.telenor.dk%2F&amp;esheet=54095585&amp;newsitemid=20240722892898&amp;lan=en-US&amp;anchor=Telenor+Denmark&amp;index=1&amp;md5=fb087a42752aaaf15afadc6fc7e486b9">Telenor Denmark</a>, the second-largest mobile operator in the Danish market, is a trailblazer for customer-first innovation. To reinforce its position at the forefront of digital telecommunications commerce and continue to provide excellent customer experiences, Telenor Denmark chose&nbsp;<a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.csgi.com%2F%3Futm_source%3DPress%2BRelease%26utm_medium%3DPR&amp;esheet=54095585&amp;newsitemid=20240722892898&amp;lan=en-US&amp;anchor=CSG%26%23174%3B&amp;index=2&amp;md5=2917b9037dd1cabd109ea72845392e85">CSG&reg;</a>&lsquo;s (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CSGS#NASDAQ">CSGS</a>) cloud-native, software-as-a-service (SaaS) platforms to drive its evolution into the future. This transformation turbocharges Telenor Denmark&#39;s omnichannel monetisation, improves business efficiency and future-proofs the B2C and B2B customer experience.

CSGS

Telenor Denmark Adopts CSG's Cloud Platforms to Boost Customer Experience

NASA on Monday said it chose Elon Musk&#8216;s SpaceX to provide launch service for the National Oceanic and Atmospheric Administration&#8217;s (NOAA) Joint Polar Satellite System 4 mission (JPSS 4) expected to be launched in 2027. 
What Happened: The new contract between NASA and SpaceX is valued at about $112.7 million, including launch services and other mission-related costs.
The mission is expected to be launched in 2027 from Vandenberg Space Force Base in California aboard SpaceX&#8217;s Falcon 9 rocket.
The JPSS 4 mission spacecraft is part of the multi-satellite cooperative Joint Polar Satellite System program. The constellation collects data that allows for continuous observation of Earth&#8217;s environment. 
&#8220;The Joint Polar Satellite System 4 (JPSS 4) combined with the GOES (Geostationary Operational Environmental Satellites) constellation, account for nearly all of the data used by meteorologists in creating daily forecasts and long-range weather models across the U.S.,&#8221; SpaceX said. 
Why It Matters: NASA and SpaceX are bound by several contracts.
NASA&nbsp;<a href="https://www.benzinga.com/news/24/07/39870115/spacex-ceo-elon-musk-says-safe-destruction-of-international-space-station-will-be-a-very-dramatic-ev">chose SpaceX&nbsp;to develop and deliver the U.S. Deorbit vehicle (USDV) </a>to deorbit the International Space Station (ISS) and ensure a lack of risk to populated areas in late June. SpaceX will develop the <a href="https://www.benzinga.com/news/24/06/39521319/elon-musk-envisions-building-space-station-on-moon-after-spacex-bags-nasa-contract-to-build-iss-deor">deorbit spacecraft </a>under the contract valued at $843 million and NASA will take ownership afterward and operate it through the mission.
NASA is also relying on the success of SpaceX's Starship launch vehicle to&nbsp;<a href="https://www.benzinga.com/news/23/12/36296253/51-years-since-apollo-17-elon-musk-urges-humanity-to-surpass-moon-visit-as-civilizational-high-water" target="_blank" rel="noreferrer noopener">land humans back on the moon</a>&nbsp;as part of its Artemis program. A lander version of the Starship is expected to land astronauts on the Moon no earlier than September 2026 as part of Artemis 3.
Check out more of Benzinga's Future Of Mobility coverage by&nbsp;<a href="https://www.benzinga.com/topic/mobility" target="_blank" rel="noreferrer noopener">following this link</a>.
Read More:
<ul>
<li><a href="https://www.benzinga.com/news/24/07/39877043/tesla-fsd-to-allow-users-to-wear-sunglasses-starting-with-version-12-5-elon-musk-tells-quake-video-g">Tesla FSD To Allow Users To Wear Sunglasses Starting With Version 12.5, Elon Musk Tells Quake Video Game Developer: &#8216;Tesla Has Done So Much&#8230;&#8217;</a></li>
</ul>
Photo courtesy: Shutterstock

SPACE

SpaceX Bags $113M NASA Contract To Launch Satellite System For Monitoring Earth's Environment

Tyler Winklevoss, the co-founder of cryptocurrency exchange Gemini, took aim at Rep. Alexandria Ocasio-Cortez (D-N.Y.) and other politicians for their misinterpretation of the cryptocurrency industry, warning them of potential political fallout.
What Happened: In an X post on Tuesday, Winklevoss expressed his frustration with politicians, specifically calling out AOC, for viewing the cryptocurrency industry as a special interest group. He emphasized that cryptocurrencies are owned by at least 50 million Americans, making it a general interest group.
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
<div class="wp-block-embed__wrapper">
<blockquote class="twitter-tweet" data-width="500" data-dnt="true">Politicians like AOC believe that crypto is a special interest group. They should fire their political consultants because they obviously didn&#39;t give them the data. Crypto is owned by at least 50 million Americans. This means that it is a general interest group. Anti-crypto…
&mdash; Tyler Winklevoss (@tyler) <a href="https://twitter.com/tyler/status/1815497425127199075?ref_src=twsrc%5Etfw">July 22, 2024</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
</figure>
See Also: <a href="https://www.benzinga.com/markets/cryptocurrency/24/07/39898464/bitcoin-worth-millions-moved-by-us-government-amid-rumors-of-strategic-reserve-asset-endor">Bitcoin Worth Millions Moved By US Government Amid Rumors Of Strategic Reserve Asset Endorsement</a>
Winklevoss warned politicians that their hostile stance could lead to political suicide, vowing that the industry will no longer be treated poorly. &#8220;Never again will the beltway swamp creatures treat our industry this way. Onward,&#8221; he said.
Why It Matters: Winklevoss&#8217; comments come in the wake of significant donations from him and his identical twin brother, Cameron, to candidates seen as friendly toward the industry. Last month, they <a href="https://www.benzinga.com/markets/cryptocurrency/24/06/39424615/trump-gets-2m-in-bitcoin-donations-for-2024-election-from-winklevoss-twins-the-biden-admin" target="_blank" rel="noreferrer noopener">donated $2 million</a> in Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) to former President Donald Trump&#8217;s 2024 election campaign.
More recently, the brothers donated <a href="https://www.benzinga.com/markets/cryptocurrency/24/07/39852340/elizabeth-warrens-opponent-gets-a-1m-donation-in-bitcoin-from-winklevoss-twins-spent-the-l">$1 million Bitcoin donation</a> to support&nbsp;John Deaton's&nbsp;political campaign against Senator&nbsp;Elizabeth Warren&nbsp;(D-Mass.).
The Winklevoss twins have been active in promoting Bitcoin within the sports industry, <a href="https://www.benzinga.com/markets/cryptocurrency/24/07/39896170/winklevoss-backed-real-bedford-soccer-club-embraces-michael-saylor-bitcoin-philosophy-accu">recently investing</a> in the Real Bedford soccer club, which has accumulated 82.7 BTC as part of its treasury.
Price Action: At the time of writing, Bitcoin was exchanging hands at $66,594.62, down 1.35% in the last 24 hours, according to <a href="https://pro.benzinga.com/dashboard?_gl=1&#x2A;380nj0&#x2A;_ga&#x2A;MTEyOTAyOTcxMy4xNzEzMzY0NTYy&#x2A;_ga_V7ZK73W7N0&#x2A;MTcxNDk4MzIzMi42LjEuMTcxNDk4OTE0Ni4wLjAuMA..">data from Benzinga Pro</a>.
Photo via Shutterstock
Read Next: 
<ul>
<li><a href="https://www.benzinga.com/markets/cryptocurrency/24/07/39893280/top-crypto-trader-shares-his-5-meme-coin-portfolio-picks-terms-one-the-doge-of-this-cycle">Top Crypto Trader Shares His 5 Meme Coin Portfolio Picks, Terms One &#8216;The DOGE Of This Cycle&#8217;</a></li>
</ul>
Disclaimer:&nbsp;This content was partially produced with the help of&nbsp;<a href="https://www.benzinga.com/author/benzinga-neuro" target="_blank" rel="noreferrer noopener">Benzinga Neuro</a>&nbsp;and was reviewed and published by Benzinga editors.

AOC Needs To Fire Her Consultants, Attacking Crypto 'Political Suicide,' Says Tyler Winklevoss

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Valterra Resource Corp

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Latest news for Valterra Resource Corp (OTC:VRSCF) Stock

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