Actinium's Targeted Radiotherapy Achieves 100% Bone Marrow Transplant Engraftment

Actinium Pharmaceuticals Inc ATNM highlighted data from its pivotal Phase 3 SIERRA trial evaluating Iomab-B in patients with relapsed or refractory Acute Myeloid Leukemia (AML) aged 55 years and above.
Iomab-B radiotherapy is intended to be a targeted conditioning (preparing) agent to enable a potentially curative bone marrow transplant (BMT).
Data were presented at the Society of Nuclear Medicine and Molecular Imaging Annual Meeting.
The therapy targets cells expressing CD45, a protein found only on blood cancer cells and immune cells, including bone marrow stem cells, with the radioisotope iodine-131.
100% BMT and engraftment rate for patients receiving a therapeutic dose of Iomab-B was observed compared to 18% of patients receiving physician's choice of salvage therapy on the control arm.
79% of all patients enrolled on SIERRA could proceed to BMT despite being a patient population not considered eligible for BMT with standard approaches.
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